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Cocaine and amphetamine regulated transcript (CART) in suicide attempters.

Brundin, Lena LU ; Björkqvist, Maria LU ; Träskman Bendz, Lil LU and Petersén, Åsa LU (2008) In Psychiatry Research 158(2). p.117-122
Abstract
Cocaine and amphetamine regulated transcript (CART) is a neuropeptide expressed in brain regions thought to regulate anxiety levels, depression, addiction and energy homeostasis. Individuals with a CART mutation display increased anxiety and depression. Severe anxiety is a core phenomenon of suicidality. We therefore studied levels of CART in the cerebrospinal fluid (CSF) of 98 patients with different psychiatric diagnoses, shortly after a suicide attempt. We also investigated the relationship between CSF-CART and relevant psychiatric symptoms. CART levels were determined using a radioimmunoassay and the psychiatric symptoms rated in structured interviews using the Comprehensive Psychopathological Rating Scale (CPRS) and the Karolinska... (More)
Cocaine and amphetamine regulated transcript (CART) is a neuropeptide expressed in brain regions thought to regulate anxiety levels, depression, addiction and energy homeostasis. Individuals with a CART mutation display increased anxiety and depression. Severe anxiety is a core phenomenon of suicidality. We therefore studied levels of CART in the cerebrospinal fluid (CSF) of 98 patients with different psychiatric diagnoses, shortly after a suicide attempt. We also investigated the relationship between CSF-CART and relevant psychiatric symptoms. CART levels were determined using a radioimmunoassay and the psychiatric symptoms rated in structured interviews using the Comprehensive Psychopathological Rating Scale (CPRS) and the Karolinska Scales of Personality (KSP). No differences in CSF-CART were found between the diagnostic groups or controls. However, lower CART levels were associated with a higher degree of concentration difficulties. No significant association was found between CART levels and other psychiatric symptoms. CSF-CART correlated significantly with CSF-levels of orexin, but not with corticotrophin releasing factor (CRF). Further studies on the role of CART in psychiatric diseases where concentration difficulties are prominent, such as attention deficit disorder, are warranted. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Psychiatry Research
volume
158
issue
2
pages
117 - 122
publisher
Elsevier
external identifiers
  • pmid:18096245
  • wos:000254913600001
  • scopus:39649089145
ISSN
1872-7123
DOI
10.1016/j.psychres.2007.06.031
language
English
LU publication?
yes
id
d9894671-5589-4f61-9087-0b945fce05e6 (old id 1035026)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18096245?dopt=Abstract
date added to LUP
2008-02-29 10:36:02
date last changed
2017-01-01 05:14:54
@article{d9894671-5589-4f61-9087-0b945fce05e6,
  abstract     = {Cocaine and amphetamine regulated transcript (CART) is a neuropeptide expressed in brain regions thought to regulate anxiety levels, depression, addiction and energy homeostasis. Individuals with a CART mutation display increased anxiety and depression. Severe anxiety is a core phenomenon of suicidality. We therefore studied levels of CART in the cerebrospinal fluid (CSF) of 98 patients with different psychiatric diagnoses, shortly after a suicide attempt. We also investigated the relationship between CSF-CART and relevant psychiatric symptoms. CART levels were determined using a radioimmunoassay and the psychiatric symptoms rated in structured interviews using the Comprehensive Psychopathological Rating Scale (CPRS) and the Karolinska Scales of Personality (KSP). No differences in CSF-CART were found between the diagnostic groups or controls. However, lower CART levels were associated with a higher degree of concentration difficulties. No significant association was found between CART levels and other psychiatric symptoms. CSF-CART correlated significantly with CSF-levels of orexin, but not with corticotrophin releasing factor (CRF). Further studies on the role of CART in psychiatric diseases where concentration difficulties are prominent, such as attention deficit disorder, are warranted.},
  author       = {Brundin, Lena and Björkqvist, Maria and Träskman Bendz, Lil and Petersén, Åsa},
  issn         = {1872-7123},
  language     = {eng},
  number       = {2},
  pages        = {117--122},
  publisher    = {Elsevier},
  series       = {Psychiatry Research},
  title        = {Cocaine and amphetamine regulated transcript (CART) in suicide attempters.},
  url          = {http://dx.doi.org/10.1016/j.psychres.2007.06.031},
  volume       = {158},
  year         = {2008},
}