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Endometrial expression of vasopressin, oxytocin and their receptors in patients with primary dysmenorrhoea and healthy volunteers at ovulation.

Liedman, Ragner LU ; Hansson, Stefan LU ; Howe, David; Igidbashian, Sarah; Russell, Rachel J and Åkerlund, Mats LU (2008) In European Journal of Obstetrics, Gynecology, and Reproductive Biology 137(2). p.189-192
Abstract
OBJECTIVE: To investigate gene expressions for neurohypophyseal and ovarian hormones as well as their receptors in the endometrium of women with primary dysmenorrhoea and healthy subjects at ovulation. STUDY DESIGN: A group of eight women with moderate to severe dysmenorrhoea and eight healthy subjects were compared in parallel between 18 and 35 years of age, regularly menstruating, non-overweight and nulliparous. The study was performed at The Department of Obstetrics and Gynecology, University Hospital of Lund, Sweden. Endometrial biopsies were taken around the time of ovulation, which was determined by repeated ultrasound examinations. Receptor and gene expressions for oxytocin and vasopressin in the tissue were measured. RESULTS: The... (More)
OBJECTIVE: To investigate gene expressions for neurohypophyseal and ovarian hormones as well as their receptors in the endometrium of women with primary dysmenorrhoea and healthy subjects at ovulation. STUDY DESIGN: A group of eight women with moderate to severe dysmenorrhoea and eight healthy subjects were compared in parallel between 18 and 35 years of age, regularly menstruating, non-overweight and nulliparous. The study was performed at The Department of Obstetrics and Gynecology, University Hospital of Lund, Sweden. Endometrial biopsies were taken around the time of ovulation, which was determined by repeated ultrasound examinations. Receptor and gene expressions for oxytocin and vasopressin in the tissue were measured. RESULTS: The gene expression for oxytocin receptor was significantly lower in dysmenorrhoic than in healthy women, in median 1.21 and 3.44oxytocin-receptor/actin, respectively (p=0.048). The expressions for oxytocin peptide, vasopressin V(1a) receptor, oestrogen receptor alpha, beta and progesterone receptor did not differ between the two groups. Expression of vasopressin peptide was not detectable. CONCLUSION: A lower oxytocin receptor gene expression at mid-cycle could be involved in the aetiology of primary dysmenorrhoea. However, the importance of a paracrine effect of oxytocin and its receptor at ovulation warrants further investigation. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
European Journal of Obstetrics, Gynecology, and Reproductive Biology
volume
137
issue
2
pages
189 - 192
publisher
Elsevier
external identifiers
  • pmid:18082926
  • wos:000255626000012
  • scopus:41049115187
ISSN
0301-2115
DOI
10.1016/j.ejogrb.2007.10.015
language
English
LU publication?
yes
id
e936f645-2452-476d-b26f-7c35acb902de (old id 1035223)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18082926?dopt=Abstract
date added to LUP
2009-07-09 09:12:48
date last changed
2017-07-30 03:36:11
@article{e936f645-2452-476d-b26f-7c35acb902de,
  abstract     = {OBJECTIVE: To investigate gene expressions for neurohypophyseal and ovarian hormones as well as their receptors in the endometrium of women with primary dysmenorrhoea and healthy subjects at ovulation. STUDY DESIGN: A group of eight women with moderate to severe dysmenorrhoea and eight healthy subjects were compared in parallel between 18 and 35 years of age, regularly menstruating, non-overweight and nulliparous. The study was performed at The Department of Obstetrics and Gynecology, University Hospital of Lund, Sweden. Endometrial biopsies were taken around the time of ovulation, which was determined by repeated ultrasound examinations. Receptor and gene expressions for oxytocin and vasopressin in the tissue were measured. RESULTS: The gene expression for oxytocin receptor was significantly lower in dysmenorrhoic than in healthy women, in median 1.21 and 3.44oxytocin-receptor/actin, respectively (p=0.048). The expressions for oxytocin peptide, vasopressin V(1a) receptor, oestrogen receptor alpha, beta and progesterone receptor did not differ between the two groups. Expression of vasopressin peptide was not detectable. CONCLUSION: A lower oxytocin receptor gene expression at mid-cycle could be involved in the aetiology of primary dysmenorrhoea. However, the importance of a paracrine effect of oxytocin and its receptor at ovulation warrants further investigation.},
  author       = {Liedman, Ragner and Hansson, Stefan and Howe, David and Igidbashian, Sarah and Russell, Rachel J and Åkerlund, Mats},
  issn         = {0301-2115},
  language     = {eng},
  number       = {2},
  pages        = {189--192},
  publisher    = {Elsevier},
  series       = {European Journal of Obstetrics, Gynecology, and Reproductive Biology},
  title        = {Endometrial expression of vasopressin, oxytocin and their receptors in patients with primary dysmenorrhoea and healthy volunteers at ovulation.},
  url          = {http://dx.doi.org/10.1016/j.ejogrb.2007.10.015},
  volume       = {137},
  year         = {2008},
}