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B cell lymphomas express CX(3)CR1 a non-B cell lineage adhesion molecule.

Andreasson, Ulrika LU ; Ek, Sara LU ; Merz, Hartmut; Rosenquist, Richard; Andersen, Niels; Jerkeman, Mats LU ; Dictor, Michael LU and Borrebaeck, Carl A K (2008) In Cancer Letters 259(2). p.138-145
Abstract
To study the differential expression of cell membrane-bound receptors and their potential role in growth and/or survival of the tumor cells, highly purified follicular lymphoma cells were analyzed, using gene expression analysis, and compared to non-malignant B cell populations. Filtering the genome for overexpressed genes coding for cell membrane-bound proteins/receptors resulted in a hit list of 27 identified genes. Among these, we have focused on the aberrant over expression of CX(3)CR1, in different types of B cell lymphoma, as compared to non-malignant B cells. We show that CX(3)CR1, which normally is not expressed on B cells, is expressed both at the mRNA and protein level in several subtypes of lymphoma. CX(3)CR1 has also shown to... (More)
To study the differential expression of cell membrane-bound receptors and their potential role in growth and/or survival of the tumor cells, highly purified follicular lymphoma cells were analyzed, using gene expression analysis, and compared to non-malignant B cell populations. Filtering the genome for overexpressed genes coding for cell membrane-bound proteins/receptors resulted in a hit list of 27 identified genes. Among these, we have focused on the aberrant over expression of CX(3)CR1, in different types of B cell lymphoma, as compared to non-malignant B cells. We show that CX(3)CR1, which normally is not expressed on B cells, is expressed both at the mRNA and protein level in several subtypes of lymphoma. CX(3)CR1 has also shown to be involved in the homing to specific tissues that express the ligand, CX(3)CL1, in breast and prostate cancer and may thus be involved in dissemination of lymphoma. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Cancer Letters
volume
259
issue
2
pages
138 - 145
publisher
Elsevier
external identifiers
  • pmid:18060687
  • wos:000253023100002
  • scopus:37049035312
ISSN
1872-7980
DOI
10.1016/j.canlet.2007.10.031
project
CREATE Health
language
English
LU publication?
yes
id
76ff3643-38af-4699-92e1-05027d5d526a (old id 1035621)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18060687?dopt=Abstract
date added to LUP
2008-02-27 11:10:15
date last changed
2017-08-27 05:49:15
@article{76ff3643-38af-4699-92e1-05027d5d526a,
  abstract     = {To study the differential expression of cell membrane-bound receptors and their potential role in growth and/or survival of the tumor cells, highly purified follicular lymphoma cells were analyzed, using gene expression analysis, and compared to non-malignant B cell populations. Filtering the genome for overexpressed genes coding for cell membrane-bound proteins/receptors resulted in a hit list of 27 identified genes. Among these, we have focused on the aberrant over expression of CX(3)CR1, in different types of B cell lymphoma, as compared to non-malignant B cells. We show that CX(3)CR1, which normally is not expressed on B cells, is expressed both at the mRNA and protein level in several subtypes of lymphoma. CX(3)CR1 has also shown to be involved in the homing to specific tissues that express the ligand, CX(3)CL1, in breast and prostate cancer and may thus be involved in dissemination of lymphoma.},
  author       = {Andreasson, Ulrika and Ek, Sara and Merz, Hartmut and Rosenquist, Richard and Andersen, Niels and Jerkeman, Mats and Dictor, Michael and Borrebaeck, Carl A K},
  issn         = {1872-7980},
  language     = {eng},
  number       = {2},
  pages        = {138--145},
  publisher    = {Elsevier},
  series       = {Cancer Letters},
  title        = {B cell lymphomas express CX(3)CR1 a non-B cell lineage adhesion molecule.},
  url          = {http://dx.doi.org/10.1016/j.canlet.2007.10.031},
  volume       = {259},
  year         = {2008},
}