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Risk of somatic diseases in offspring of survivors with childhood or adolescent central nervous system tumor in Sweden

Huang, Wuqing LU orcid ; Sundquist, Kristina LU ; Sundquist, Jan LU and Ji, Jianguang LU orcid (2021) In International Journal of Cancer 148(9). p.2184-2192
Abstract

With the improvement of treatments, a growing number of survivors with childhood or adolescent central nervous system (CNS) tumor are parenting their own children. We aimed to explore the risk of somatic diseases among children of these survivors compared with population controls. Children of survivors with CNS tumor below age of 20 were identified between 1973 and 2014 by combining the several Swedish registers. Five children without parental CNS tumor were matched randomly to generate the population comparisons. Relative risk (RR) and absolute excess risk (AER) were calculated for overall somatic diseases, and hazard ratio (HR) was calculated for specific type of somatic diseases. A total of 2231 somatic disease diagnoses were... (More)

With the improvement of treatments, a growing number of survivors with childhood or adolescent central nervous system (CNS) tumor are parenting their own children. We aimed to explore the risk of somatic diseases among children of these survivors compared with population controls. Children of survivors with CNS tumor below age of 20 were identified between 1973 and 2014 by combining the several Swedish registers. Five children without parental CNS tumor were matched randomly to generate the population comparisons. Relative risk (RR) and absolute excess risk (AER) were calculated for overall somatic diseases, and hazard ratio (HR) was calculated for specific type of somatic diseases. A total of 2231 somatic disease diagnoses were identified in children of survivors with a cumulative incidence rate of 94.77 per 1000 person-years, whereas the rate was 92.79 in matched comparisons thus resulting in an overall RR of 1.02 (95% CI=0.98-1.07) and AER of 1.98 (95%CI=-2.06, 6.13). Specifically, five of 1364 children of survivors had CNS tumor with an incidence rate of 0.21 per 1000 person-year, whereas the rate was 0.04 in children of matched children, generating a HR of 4.91 (95%CI=1.42-16.96). Children of male survivors were at a statistically increased risk of malignancy, as well as infectious and parasitic diseases. In conclusion, no significantly higher risk of overall somatic diseases was found in children of survivors with CNS tumor before the age of 20, but children with a paternal diagnosis of CNS tumor had significantly increased risk of malignancies and infectious and parasitic diseases. This article is protected by copyright. All rights reserved.

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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
International Journal of Cancer
volume
148
issue
9
pages
2184 - 2192
publisher
John Wiley & Sons Inc.
external identifiers
  • scopus:85096706625
  • pmid:33186480
ISSN
0020-7136
DOI
10.1002/ijc.33394
project
Health status and academic performance in offspring of central nervous system tumor survivors
language
English
LU publication?
yes
additional info
This article is protected by copyright. All rights reserved.
id
1037aec0-bff9-4892-b5ca-88e0a1bbd7cf
date added to LUP
2020-11-19 09:09:19
date last changed
2024-03-20 19:54:02
@article{1037aec0-bff9-4892-b5ca-88e0a1bbd7cf,
  abstract     = {{<p>With the improvement of treatments, a growing number of survivors with childhood or adolescent central nervous system (CNS) tumor are parenting their own children. We aimed to explore the risk of somatic diseases among children of these survivors compared with population controls. Children of survivors with CNS tumor below age of 20 were identified between 1973 and 2014 by combining the several Swedish registers. Five children without parental CNS tumor were matched randomly to generate the population comparisons. Relative risk (RR) and absolute excess risk (AER) were calculated for overall somatic diseases, and hazard ratio (HR) was calculated for specific type of somatic diseases. A total of 2231 somatic disease diagnoses were identified in children of survivors with a cumulative incidence rate of 94.77 per 1000 person-years, whereas the rate was 92.79 in matched comparisons thus resulting in an overall RR of 1.02 (95% CI=0.98-1.07) and AER of 1.98 (95%CI=-2.06, 6.13). Specifically, five of 1364 children of survivors had CNS tumor with an incidence rate of 0.21 per 1000 person-year, whereas the rate was 0.04 in children of matched children, generating a HR of 4.91 (95%CI=1.42-16.96). Children of male survivors were at a statistically increased risk of malignancy, as well as infectious and parasitic diseases. In conclusion, no significantly higher risk of overall somatic diseases was found in children of survivors with CNS tumor before the age of 20, but children with a paternal diagnosis of CNS tumor had significantly increased risk of malignancies and infectious and parasitic diseases. This article is protected by copyright. All rights reserved.</p>}},
  author       = {{Huang, Wuqing and Sundquist, Kristina and Sundquist, Jan and Ji, Jianguang}},
  issn         = {{0020-7136}},
  language     = {{eng}},
  number       = {{9}},
  pages        = {{2184--2192}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{International Journal of Cancer}},
  title        = {{Risk of somatic diseases in offspring of survivors with childhood or adolescent central nervous system tumor in Sweden}},
  url          = {{http://dx.doi.org/10.1002/ijc.33394}},
  doi          = {{10.1002/ijc.33394}},
  volume       = {{148}},
  year         = {{2021}},
}