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Left Atrial Posterior Wall Thickness in Patients with and without Atrial Fibrillation: Data from 298 Consecutive Autopsies.

Platonov, Pyotr LU ; Ivanov, Vitaly; Ho, Siew Yen and Mitrofanova, Lubov (2008) In Journal of Cardiovascular Electrophysiology 19(7). p.689-692
Abstract
Introduction: Radiofrequency ablation of atrial fibrillation (AF) is associated with energy delivery on the posterior left atrial (LA) wall with small but significant risk of life-threatening complications. Anatomy of LA walls has been described, but wall thickness in patients with AF has not been studied systematically. The aim of the present study was to describe LA posterior wall thickness in patients with and without history of AF. Methods and Results: Heart mass and LA wall thickness was measured during 298 consecutive autopsies (142 male, age 61 +/- 17 years). LA posterior wall was measured at three levels: between the superior pulmonary veins (SPV), in the center of the posterior LA wall (CPV), and between the inferior pulmonary... (More)
Introduction: Radiofrequency ablation of atrial fibrillation (AF) is associated with energy delivery on the posterior left atrial (LA) wall with small but significant risk of life-threatening complications. Anatomy of LA walls has been described, but wall thickness in patients with AF has not been studied systematically. The aim of the present study was to describe LA posterior wall thickness in patients with and without history of AF. Methods and Results: Heart mass and LA wall thickness was measured during 298 consecutive autopsies (142 male, age 61 +/- 17 years). LA posterior wall was measured at three levels: between the superior pulmonary veins (SPV), in the center of the posterior LA wall (CPV), and between the inferior pulmonary veins (IPV). Information about AF history was obtained from medical records. Fifty-nine subjects (20%) had documented AF. They were older than subjects without AF (74 +/- 10 years vs 58 +/- 17 years, P < 0.0001) and had greater heart mass (522 +/- 114 g vs 389 +/- 99 g, P < 0.0001). LA posterior wall thickness increased from the most superior to the most inferior measured level (2.3 +/- 0.9 mm vs 2.5 +/- 1.0 mm vs 2.9 +/- 1.3 mm for SPV, CPV, and IPV, respectively; P < 0.001). Subjects with AF history had thinner LA posterior wall at CPV and IPV compared with those without AF. Conclusions: LA posterior wall thickness is described on a large series of consecutive autopsies. LA posterior wall is found to be generally thinner in patients with history of AF. Study results have clinical implications for understanding complication risk and improvement of safety of AF ablation procedures. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
atrial fibrillation, ablation, complications, pathology, atrial anatomy
in
Journal of Cardiovascular Electrophysiology
volume
19
issue
7
pages
689 - 692
publisher
Wiley-Blackwell
external identifiers
  • pmid:18284501
  • wos:000257711200008
  • scopus:48049098014
ISSN
1540-8167
DOI
10.1111/j.1540-8167.2008.01102.x
language
English
LU publication?
yes
id
52cad6ad-a476-4e40-b757-37941c3e1589 (old id 1041733)
date added to LUP
2008-03-06 13:58:40
date last changed
2017-07-23 03:43:27
@article{52cad6ad-a476-4e40-b757-37941c3e1589,
  abstract     = {Introduction: Radiofrequency ablation of atrial fibrillation (AF) is associated with energy delivery on the posterior left atrial (LA) wall with small but significant risk of life-threatening complications. Anatomy of LA walls has been described, but wall thickness in patients with AF has not been studied systematically. The aim of the present study was to describe LA posterior wall thickness in patients with and without history of AF. Methods and Results: Heart mass and LA wall thickness was measured during 298 consecutive autopsies (142 male, age 61 +/- 17 years). LA posterior wall was measured at three levels: between the superior pulmonary veins (SPV), in the center of the posterior LA wall (CPV), and between the inferior pulmonary veins (IPV). Information about AF history was obtained from medical records. Fifty-nine subjects (20%) had documented AF. They were older than subjects without AF (74 +/- 10 years vs 58 +/- 17 years, P &lt; 0.0001) and had greater heart mass (522 +/- 114 g vs 389 +/- 99 g, P &lt; 0.0001). LA posterior wall thickness increased from the most superior to the most inferior measured level (2.3 +/- 0.9 mm vs 2.5 +/- 1.0 mm vs 2.9 +/- 1.3 mm for SPV, CPV, and IPV, respectively; P &lt; 0.001). Subjects with AF history had thinner LA posterior wall at CPV and IPV compared with those without AF. Conclusions: LA posterior wall thickness is described on a large series of consecutive autopsies. LA posterior wall is found to be generally thinner in patients with history of AF. Study results have clinical implications for understanding complication risk and improvement of safety of AF ablation procedures.},
  author       = {Platonov, Pyotr and Ivanov, Vitaly and Ho, Siew Yen and Mitrofanova, Lubov},
  issn         = {1540-8167},
  keyword      = {atrial fibrillation,ablation,complications,pathology,atrial anatomy},
  language     = {eng},
  number       = {7},
  pages        = {689--692},
  publisher    = {Wiley-Blackwell},
  series       = {Journal of Cardiovascular Electrophysiology},
  title        = {Left Atrial Posterior Wall Thickness in Patients with and without Atrial Fibrillation: Data from 298 Consecutive Autopsies.},
  url          = {http://dx.doi.org/10.1111/j.1540-8167.2008.01102.x},
  volume       = {19},
  year         = {2008},
}