Bioactive alkenylphenols from Piper obliquum.
(2008) In Bioorganic & Medicinal Chemistry 16(7). p.4120-4126- Abstract
- Various parts of Piper obliquum Ruíz & Pavon yielded the new alkenylphenols obliquol A (1) and obliquol B (2), the new 4-chromanone 3 together with the known compounds 4 and 5. A synthesis of obliquol B (2) was developed in order to confirm its structure and to provide sufficient amounts for biological testing. Compounds 1 and 2 have antibacterial activity comparable to that of ampicillin, 2 in addition possesses potent anti-NF-kappaB activity by targeting early events in the TNFalpha-induced NF-kappaB inflammatory pathway, which may explain the effects reported for the traditional use of the plant.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1041926
- author
- Valdivia, Carola LU ; Marquez, Nieves ; Eriksson, John LU ; Vilaseca, Antonio ; Muñoz, Eduardo and Sterner, Olov LU
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Bioorganic & Medicinal Chemistry
- volume
- 16
- issue
- 7
- pages
- 4120 - 4126
- publisher
- Elsevier
- external identifiers
-
- pmid:18276144
- wos:000255245900065
- scopus:41849129583
- ISSN
- 0968-0896
- DOI
- 10.1016/j.bmc.2008.01.018
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Applied Microbiology (LTH) (011001021), Organic chemistry (S/LTH) (011001240)
- id
- 5505df31-494e-4283-a610-8bb19715417d (old id 1041926)
- date added to LUP
- 2016-04-01 11:42:16
- date last changed
- 2022-03-20 17:44:22
@article{5505df31-494e-4283-a610-8bb19715417d, abstract = {{Various parts of Piper obliquum Ruíz & Pavon yielded the new alkenylphenols obliquol A (1) and obliquol B (2), the new 4-chromanone 3 together with the known compounds 4 and 5. A synthesis of obliquol B (2) was developed in order to confirm its structure and to provide sufficient amounts for biological testing. Compounds 1 and 2 have antibacterial activity comparable to that of ampicillin, 2 in addition possesses potent anti-NF-kappaB activity by targeting early events in the TNFalpha-induced NF-kappaB inflammatory pathway, which may explain the effects reported for the traditional use of the plant.}}, author = {{Valdivia, Carola and Marquez, Nieves and Eriksson, John and Vilaseca, Antonio and Muñoz, Eduardo and Sterner, Olov}}, issn = {{0968-0896}}, language = {{eng}}, number = {{7}}, pages = {{4120--4126}}, publisher = {{Elsevier}}, series = {{Bioorganic & Medicinal Chemistry}}, title = {{Bioactive alkenylphenols from Piper obliquum.}}, url = {{http://dx.doi.org/10.1016/j.bmc.2008.01.018}}, doi = {{10.1016/j.bmc.2008.01.018}}, volume = {{16}}, year = {{2008}}, }