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Bioactive alkenylphenols from Piper obliquum.

Valdivia, Carola LU ; Marquez, Nieves; Eriksson, John LU ; Vilaseca, Antonio; Muñoz, Eduardo and Sterner, Olov LU (2008) In Bioorganic & Medicinal Chemistry 16(7). p.4120-4126
Abstract
Various parts of Piper obliquum Ruíz & Pavon yielded the new alkenylphenols obliquol A (1) and obliquol B (2), the new 4-chromanone 3 together with the known compounds 4 and 5. A synthesis of obliquol B (2) was developed in order to confirm its structure and to provide sufficient amounts for biological testing. Compounds 1 and 2 have antibacterial activity comparable to that of ampicillin, 2 in addition possesses potent anti-NF-kappaB activity by targeting early events in the TNFalpha-induced NF-kappaB inflammatory pathway, which may explain the effects reported for the traditional use of the plant.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Bioorganic & Medicinal Chemistry
volume
16
issue
7
pages
4120 - 4126
publisher
Elsevier
external identifiers
  • pmid:18276144
  • wos:000255245900065
  • scopus:41849129583
ISSN
0968-0896
DOI
10.1016/j.bmc.2008.01.018
language
English
LU publication?
yes
id
5505df31-494e-4283-a610-8bb19715417d (old id 1041926)
date added to LUP
2008-03-25 16:52:03
date last changed
2017-01-01 04:27:36
@article{5505df31-494e-4283-a610-8bb19715417d,
  abstract     = {Various parts of Piper obliquum Ruíz & Pavon yielded the new alkenylphenols obliquol A (1) and obliquol B (2), the new 4-chromanone 3 together with the known compounds 4 and 5. A synthesis of obliquol B (2) was developed in order to confirm its structure and to provide sufficient amounts for biological testing. Compounds 1 and 2 have antibacterial activity comparable to that of ampicillin, 2 in addition possesses potent anti-NF-kappaB activity by targeting early events in the TNFalpha-induced NF-kappaB inflammatory pathway, which may explain the effects reported for the traditional use of the plant.},
  author       = {Valdivia, Carola and Marquez, Nieves and Eriksson, John and Vilaseca, Antonio and Muñoz, Eduardo and Sterner, Olov},
  issn         = {0968-0896},
  language     = {eng},
  number       = {7},
  pages        = {4120--4126},
  publisher    = {Elsevier},
  series       = {Bioorganic & Medicinal Chemistry},
  title        = {Bioactive alkenylphenols from Piper obliquum.},
  url          = {http://dx.doi.org/10.1016/j.bmc.2008.01.018},
  volume       = {16},
  year         = {2008},
}