Advanced

Management of advanced prostate cancer: can we improve on androgen deprivation therapy?

Anderson, J; Abrahamsson, Per-Anders LU ; Crawford, David; Miller, Kurt and Tombal, Bertrand (2008) In BJU International 101. p.1497-1501
Abstract
Gonadotrophin-releasing hormone (GnRH) agonists are currently the mainstay in the management of advanced prostate cancer. Used either as monotherapy or combined with antiandrogens, GnRH agonists suppress serum testosterone levels and thus slow the growth of the tumour cells that depend on testosterone for growth. GnRH agonists have largely replaced orchidectomy in the management of advanced prostate cancer, because patients are reluctant to undergo surgical castration. However, can we do better in androgen-deprivation therapy? There is some evidence to suggest that GnRH agonists do not achieve the level of testosterone suppression attained with orchidectomy, or as rapidly, factors which could be expected to affect overall survival.... (More)
Gonadotrophin-releasing hormone (GnRH) agonists are currently the mainstay in the management of advanced prostate cancer. Used either as monotherapy or combined with antiandrogens, GnRH agonists suppress serum testosterone levels and thus slow the growth of the tumour cells that depend on testosterone for growth. GnRH agonists have largely replaced orchidectomy in the management of advanced prostate cancer, because patients are reluctant to undergo surgical castration. However, can we do better in androgen-deprivation therapy? There is some evidence to suggest that GnRH agonists do not achieve the level of testosterone suppression attained with orchidectomy, or as rapidly, factors which could be expected to affect overall survival. Together, these observations highlight the need to develop newer agents that can achieve rapid, profound and sustained testosterone suppression, equivalent to that with orchidectomy. Preliminary data for the GnRH blocker, degarelix, suggest that this new agent might overcome the shortcomings associated with GnRH agonists. Further clinical data are therefore awaited with much interest. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
BJU International
volume
101
pages
1497 - 1501
publisher
Blackwell Science Ltd
external identifiers
  • pmid:18336613
  • wos:000255935200005
  • scopus:43949144620
ISSN
1464-4096
DOI
10.1111/j.1464-410X.2008.07590.x
language
English
LU publication?
yes
id
6714c214-f8f3-4f2f-a6fa-f05f148d5db7 (old id 1052512)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18336613?dopt=Abstract
date added to LUP
2008-04-01 08:35:57
date last changed
2017-01-01 07:33:37
@article{6714c214-f8f3-4f2f-a6fa-f05f148d5db7,
  abstract     = {Gonadotrophin-releasing hormone (GnRH) agonists are currently the mainstay in the management of advanced prostate cancer. Used either as monotherapy or combined with antiandrogens, GnRH agonists suppress serum testosterone levels and thus slow the growth of the tumour cells that depend on testosterone for growth. GnRH agonists have largely replaced orchidectomy in the management of advanced prostate cancer, because patients are reluctant to undergo surgical castration. However, can we do better in androgen-deprivation therapy? There is some evidence to suggest that GnRH agonists do not achieve the level of testosterone suppression attained with orchidectomy, or as rapidly, factors which could be expected to affect overall survival. Together, these observations highlight the need to develop newer agents that can achieve rapid, profound and sustained testosterone suppression, equivalent to that with orchidectomy. Preliminary data for the GnRH blocker, degarelix, suggest that this new agent might overcome the shortcomings associated with GnRH agonists. Further clinical data are therefore awaited with much interest.},
  author       = {Anderson, J and Abrahamsson, Per-Anders and Crawford, David and Miller, Kurt and Tombal, Bertrand},
  issn         = {1464-4096},
  language     = {eng},
  pages        = {1497--1501},
  publisher    = {Blackwell Science Ltd},
  series       = {BJU International},
  title        = {Management of advanced prostate cancer: can we improve on androgen deprivation therapy?},
  url          = {http://dx.doi.org/10.1111/j.1464-410X.2008.07590.x},
  volume       = {101},
  year         = {2008},
}