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NMR Study of the Sorption Behavior of Benzyl Alcohol Derivatives into Sonicated and Extruded Dioctadecyldimethylammonium Chloride (DODAC) Dispersions: The Relevance of Membrane Fluidity.

Saveyn, Pieter LU ; Cocquyt, Ellen; Sinnaeve, Davy; Martins, José; Topgaard, Daniel LU and Meeren, Paul (2008) In Langmuir 24(7). p.3082-3089
Abstract
The sorption behavior of three benzyl alcohol derivatives with different hydrophobicities into sonicated and extruded DODAC dispersions has been studied using NMR spectroscopy and NMR diffusometry. We show that there is an increased sorption into a sonicated dispersion below the phase-transition temperature (Tm) as compared to an extruded dispersion. This may be explained by the incomplete lipid chain freezing of charged lipids as a result of the sonication process. Around Tm, a sorption maximum is found that is attributed to the high bilayer disorder under this condition. In addition, a sorption increase and a fluidizing effect at increasing benzyl alcohol derivative concentrations are observed that provide additional evidence for the... (More)
The sorption behavior of three benzyl alcohol derivatives with different hydrophobicities into sonicated and extruded DODAC dispersions has been studied using NMR spectroscopy and NMR diffusometry. We show that there is an increased sorption into a sonicated dispersion below the phase-transition temperature (Tm) as compared to an extruded dispersion. This may be explained by the incomplete lipid chain freezing of charged lipids as a result of the sonication process. Around Tm, a sorption maximum is found that is attributed to the high bilayer disorder under this condition. In addition, a sorption increase and a fluidizing effect at increasing benzyl alcohol derivative concentrations are observed that provide additional evidence for the relevance of the bilayer fluidity on the sorption of hydrophobic components. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Langmuir
volume
24
issue
7
pages
3082 - 3089
publisher
The American Chemical Society
external identifiers
  • pmid:18312006
  • wos:000254480500021
  • scopus:42249101949
ISSN
0743-7463
DOI
10.1021/la703285b
language
English
LU publication?
yes
id
43600928-2b47-4141-acc4-cf0ed4f08e2a (old id 1052900)
date added to LUP
2008-04-28 21:08:19
date last changed
2017-01-01 04:45:34
@article{43600928-2b47-4141-acc4-cf0ed4f08e2a,
  abstract     = {The sorption behavior of three benzyl alcohol derivatives with different hydrophobicities into sonicated and extruded DODAC dispersions has been studied using NMR spectroscopy and NMR diffusometry. We show that there is an increased sorption into a sonicated dispersion below the phase-transition temperature (Tm) as compared to an extruded dispersion. This may be explained by the incomplete lipid chain freezing of charged lipids as a result of the sonication process. Around Tm, a sorption maximum is found that is attributed to the high bilayer disorder under this condition. In addition, a sorption increase and a fluidizing effect at increasing benzyl alcohol derivative concentrations are observed that provide additional evidence for the relevance of the bilayer fluidity on the sorption of hydrophobic components.},
  author       = {Saveyn, Pieter and Cocquyt, Ellen and Sinnaeve, Davy and Martins, José and Topgaard, Daniel and Meeren, Paul},
  issn         = {0743-7463},
  language     = {eng},
  number       = {7},
  pages        = {3082--3089},
  publisher    = {The American Chemical Society},
  series       = {Langmuir},
  title        = {NMR Study of the Sorption Behavior of Benzyl Alcohol Derivatives into Sonicated and Extruded Dioctadecyldimethylammonium Chloride (DODAC) Dispersions: The Relevance of Membrane Fluidity.},
  url          = {http://dx.doi.org/10.1021/la703285b},
  volume       = {24},
  year         = {2008},
}