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Population-based type-specific prevalence of high-risk human papillomavirus infection in middle-aged Swedish Women.

Forslund, Ola LU ; Antonsson, Annika LU ; Edlund, Karin; van Den Brule, Adrian J C; Hansson, Bengt-Göran LU ; Meijer, Chris J L M; Ryd, Walter; Rylander, Eva; Strand, Anders and Wadell, Göran, et al. (2002) In Journal of Medical Virology 66(4). p.535-541
Abstract
Human papillomavirus (HPV) DNA testing can be used to identify women at risk of the development of cervical cancer. The cost-effectiveness of HPV screening is dependent on the type-specific HPV prevalence in the general population. The present study describes the prevalence and spectrum of high-risk HPV types found in a large real-life population-based HPV screening trial undertaken entirely within the cervical screening program offered to middle-aged Swedish women. Cervical brush samples from 6,123 women aged 32-38 years were analyzed using a general HPV primer (GP5(+)/6(+)) polymerase chain reaction-enzyme immunoassay (PCR-EIA) combined with reverse dot-blot hybridization for confirmation and HPV typing by a single assay. In this study,... (More)
Human papillomavirus (HPV) DNA testing can be used to identify women at risk of the development of cervical cancer. The cost-effectiveness of HPV screening is dependent on the type-specific HPV prevalence in the general population. The present study describes the prevalence and spectrum of high-risk HPV types found in a large real-life population-based HPV screening trial undertaken entirely within the cervical screening program offered to middle-aged Swedish women. Cervical brush samples from 6,123 women aged 32-38 years were analyzed using a general HPV primer (GP5(+)/6(+)) polymerase chain reaction-enzyme immunoassay (PCR-EIA) combined with reverse dot-blot hybridization for confirmation and HPV typing by a single assay. In this study, 6.8% (95% CI 6.2-7.5) (417/6,123) were confirmed as high-risk HPV positive. Infections with 13 different high-risk HPV types were detected, of which HPV 16 was the most prevalent type (2.1%; 128/6,123), followed by HPV 31 (1.1%; 67/6,123). Any one of the HPV types 18, 33, 35, 39, 45, 51, 52, 56, 58, 59, or 66 was detected in 3.6% (223/6,123) of the women. Infection with two, three, and five types simultaneously was identified in 32, 5, and 1 women, respectively. The combination of PCR-EIA as a screening test and reverse dot-blot hybridization as a confirmatory test, was found to be readily applicable to a real-life population-based cervical screening. The type-specific HPV prevalence found support in previous modeling studies suggesting that HPV screening may be a favorable cervical screening strategy. (Less)
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published
subject
keywords
Human papillomavirus, Women, Mass Screening
in
Journal of Medical Virology
volume
66
issue
4
pages
535 - 541
publisher
John Wiley & Sons
external identifiers
  • wos:000174047600015
  • pmid:11857534
  • scopus:0036194578
ISSN
1096-9071
DOI
10.1002/jmv.2178
language
English
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yes
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6e170a1f-e3a2-4abf-bf73-a52a8ed3f540 (old id 105863)
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http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11857534&dopt=Abstract
date added to LUP
2007-07-24 16:27:58
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2017-03-05 03:40:20
@article{6e170a1f-e3a2-4abf-bf73-a52a8ed3f540,
  abstract     = {Human papillomavirus (HPV) DNA testing can be used to identify women at risk of the development of cervical cancer. The cost-effectiveness of HPV screening is dependent on the type-specific HPV prevalence in the general population. The present study describes the prevalence and spectrum of high-risk HPV types found in a large real-life population-based HPV screening trial undertaken entirely within the cervical screening program offered to middle-aged Swedish women. Cervical brush samples from 6,123 women aged 32-38 years were analyzed using a general HPV primer (GP5(+)/6(+)) polymerase chain reaction-enzyme immunoassay (PCR-EIA) combined with reverse dot-blot hybridization for confirmation and HPV typing by a single assay. In this study, 6.8% (95% CI 6.2-7.5) (417/6,123) were confirmed as high-risk HPV positive. Infections with 13 different high-risk HPV types were detected, of which HPV 16 was the most prevalent type (2.1%; 128/6,123), followed by HPV 31 (1.1%; 67/6,123). Any one of the HPV types 18, 33, 35, 39, 45, 51, 52, 56, 58, 59, or 66 was detected in 3.6% (223/6,123) of the women. Infection with two, three, and five types simultaneously was identified in 32, 5, and 1 women, respectively. The combination of PCR-EIA as a screening test and reverse dot-blot hybridization as a confirmatory test, was found to be readily applicable to a real-life population-based cervical screening. The type-specific HPV prevalence found support in previous modeling studies suggesting that HPV screening may be a favorable cervical screening strategy.},
  author       = {Forslund, Ola and Antonsson, Annika and Edlund, Karin and van Den Brule, Adrian J C and Hansson, Bengt-Göran and Meijer, Chris J L M and Ryd, Walter and Rylander, Eva and Strand, Anders and Wadell, Göran and Dillner, Joakim and Johansson, Bo},
  issn         = {1096-9071},
  keyword      = {Human papillomavirus,Women,Mass Screening},
  language     = {eng},
  number       = {4},
  pages        = {535--541},
  publisher    = {John Wiley & Sons},
  series       = {Journal of Medical Virology},
  title        = {Population-based type-specific prevalence of high-risk human papillomavirus infection in middle-aged Swedish Women.},
  url          = {http://dx.doi.org/10.1002/jmv.2178},
  volume       = {66},
  year         = {2002},
}