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Karyotypic heterogeneity and clonal evolution in squamous cell carcinomas of the head and neck.

Jin, Charlotte LU ; Jin, Yuesheng LU ; Wennerberg, Johan LU ; Åkervall, Jan LU ; Dictor, Michael LU and Mertens, Fredrik LU (2002) In Cancer Genetics and Cytogenetics1979-01-01+01:002011-01-01+01:00 132(2). p.85-96
Abstract
Head and neck squamous cell carcinomas (HNSCC) are often characterized by complex karyotypic changes, and a substantial proportion of the reported tumors have shown intratumor heterogeneity in the form of cytogenetically related (40%) or unrelated clones (20%). In order to study intratumor heterogeneity and to distinguish the temporal order of chromosome rearrangements in these tumors, two or more samples from different areas of the same tumor were separately examined in 19 HNSCC, yielding karyotypes from a total of 42 tumor samples. Intrasample heterogeneity was observed in 16 samples. Two samples displayed both related and unrelated multiple clones, four samples showed only multiple unrelated clones, and the remaining 10 samples had only... (More)
Head and neck squamous cell carcinomas (HNSCC) are often characterized by complex karyotypic changes, and a substantial proportion of the reported tumors have shown intratumor heterogeneity in the form of cytogenetically related (40%) or unrelated clones (20%). In order to study intratumor heterogeneity and to distinguish the temporal order of chromosome rearrangements in these tumors, two or more samples from different areas of the same tumor were separately examined in 19 HNSCC, yielding karyotypes from a total of 42 tumor samples. Intrasample heterogeneity was observed in 16 samples. Two samples displayed both related and unrelated multiple clones, four samples showed only multiple unrelated clones, and the remaining 10 samples had only related subclones. Intersample heterogeneity was detected in all but one tumor. Five tumors showed both cytogenetically related and unrelated multiple clones, 11 were found to have only related subclones, and the remaining two tumors showed only unrelated clones. Clonal evolution could be assessed in 13 tumors. A comparison of chromosome imbalances in different subclones from these tumors suggests that partial or entire loss of 3p, 8p, 9p, and 18q and gain of genetic material from 3q and 8q are likely to be early genetic events. In contrast, loss of 1q, 6p, 7q, and chromosome 10, as well as gain of chromosome arms 5p and 7p, are most probably later genetic events. One of the examined tumors contained two highly complex clones that were cytogenetically unrelated, indicating that this tumor had a multicellular origin. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Karyotyping, Head and Neck Neoplasms, Genetic Heterogeneity, Carcinoma
in
Cancer Genetics and Cytogenetics1979-01-01+01:002011-01-01+01:00
volume
132
issue
2
pages
85 - 96
publisher
Elsevier
external identifiers
  • pmid:11850067
  • wos:000174032900001
  • scopus:0037081817
ISSN
0165-4608
DOI
10.1016/S0165-4608(01)00535-0
language
English
LU publication?
yes
id
3dbefc16-1acd-420b-84e4-ae1fd4f6e3ab (old id 105950)
alternative location
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11850067&dopt=Abstract
date added to LUP
2007-07-07 08:47:41
date last changed
2017-07-09 04:28:18
@article{3dbefc16-1acd-420b-84e4-ae1fd4f6e3ab,
  abstract     = {Head and neck squamous cell carcinomas (HNSCC) are often characterized by complex karyotypic changes, and a substantial proportion of the reported tumors have shown intratumor heterogeneity in the form of cytogenetically related (40%) or unrelated clones (20%). In order to study intratumor heterogeneity and to distinguish the temporal order of chromosome rearrangements in these tumors, two or more samples from different areas of the same tumor were separately examined in 19 HNSCC, yielding karyotypes from a total of 42 tumor samples. Intrasample heterogeneity was observed in 16 samples. Two samples displayed both related and unrelated multiple clones, four samples showed only multiple unrelated clones, and the remaining 10 samples had only related subclones. Intersample heterogeneity was detected in all but one tumor. Five tumors showed both cytogenetically related and unrelated multiple clones, 11 were found to have only related subclones, and the remaining two tumors showed only unrelated clones. Clonal evolution could be assessed in 13 tumors. A comparison of chromosome imbalances in different subclones from these tumors suggests that partial or entire loss of 3p, 8p, 9p, and 18q and gain of genetic material from 3q and 8q are likely to be early genetic events. In contrast, loss of 1q, 6p, 7q, and chromosome 10, as well as gain of chromosome arms 5p and 7p, are most probably later genetic events. One of the examined tumors contained two highly complex clones that were cytogenetically unrelated, indicating that this tumor had a multicellular origin.},
  author       = {Jin, Charlotte and Jin, Yuesheng and Wennerberg, Johan and Åkervall, Jan and Dictor, Michael and Mertens, Fredrik},
  issn         = {0165-4608},
  keyword      = {Karyotyping,Head and Neck Neoplasms,Genetic Heterogeneity,Carcinoma},
  language     = {eng},
  number       = {2},
  pages        = {85--96},
  publisher    = {Elsevier},
  series       = {Cancer Genetics and Cytogenetics1979-01-01+01:002011-01-01+01:00},
  title        = {Karyotypic heterogeneity and clonal evolution in squamous cell carcinomas of the head and neck.},
  url          = {http://dx.doi.org/10.1016/S0165-4608(01)00535-0},
  volume       = {132},
  year         = {2002},
}