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Extra-articular cartilage affected in collagen-induced, but not pristane-induced, arthritis models.

Liedberg, Ann-Sofie LU ; Lu, Shemin LU and Holmdahl, Rikard LU (2002) In Clinical and Experimental Immunology 127(1). p.37-42
Abstract
Rheumatoid arthritis (RA) is a chronic inflammatory disease primarily affecting cartilaginous joints but also extra-articular tissues such as the nose and upper respiratory tract. We have investigated extra-articular cartilage involvement in two commonly used animal models for RA, collagen-induced and pristane-induced arthritis, by immunizing rats with different susceptibility to disease (LEW.1 A, LEW.1F and DA rats). We found that nasal and tracheolaryngeal cartilage is affected in LEW.1 A and DA rats to varying degrees in collagen-induced arthritis but not in any strain in the pristane-induced model. Antibodies to matrilin-1, a cartilage-specific protein expressed mainly in tracheolaryngeal and nasal cartilage but not in joints, were... (More)
Rheumatoid arthritis (RA) is a chronic inflammatory disease primarily affecting cartilaginous joints but also extra-articular tissues such as the nose and upper respiratory tract. We have investigated extra-articular cartilage involvement in two commonly used animal models for RA, collagen-induced and pristane-induced arthritis, by immunizing rats with different susceptibility to disease (LEW.1 A, LEW.1F and DA rats). We found that nasal and tracheolaryngeal cartilage is affected in LEW.1 A and DA rats to varying degrees in collagen-induced arthritis but not in any strain in the pristane-induced model. Antibodies to matrilin-1, a cartilage-specific protein expressed mainly in tracheolaryngeal and nasal cartilage but not in joints, were positively associated with the presence of inflammation in nasal cartilage. In contrast, no antibody response to matrilin-1 could be detected in pristane-induced arthritis. In addition, nasal vaccination with collagen type II prior to immunization in DA rats significantly decreased the antibody response to matrilin-1 at day 56, but not at earlier time points, indicating a late protective effect on extra-articular cartilage. We conclude that pristane-induced arthritis is a joint-specific model whereas collagen-induced arthritis affect joints as well as extra-articular cartilage. Furthermore, collagen immunization induces an antibody response to matrilin-1. (Less)
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keywords
Collagen/*immunology, Disease Susceptibility, Extracellular Matrix Proteins/immunology, Glycoproteins/immunology, Immunosuppressive Agents/*immunology, Rats, Inbred Lew, Species Specificity, Support, Non-U.S. Gov't, Terpenes/*immunology, Articular/immunology/*pathology, Animal, Arthritis, Experimental/*immunology/*pathology, Autoantibodies/immunology, Cartilage
in
Clinical and Experimental Immunology
volume
127
issue
1
pages
37 - 42
publisher
British Society for Immunology
external identifiers
  • wos:000175381600006
  • pmid:11882030
  • scopus:0036177686
ISSN
0009-9104
DOI
10.1046/j.1365-2249.2002.01712.x
language
English
LU publication?
yes
id
8ad50a1f-45f2-42c1-85a1-16a8fd9bbf5e (old id 106233)
date added to LUP
2007-07-12 15:44:19
date last changed
2017-01-01 05:05:32
@article{8ad50a1f-45f2-42c1-85a1-16a8fd9bbf5e,
  abstract     = {Rheumatoid arthritis (RA) is a chronic inflammatory disease primarily affecting cartilaginous joints but also extra-articular tissues such as the nose and upper respiratory tract. We have investigated extra-articular cartilage involvement in two commonly used animal models for RA, collagen-induced and pristane-induced arthritis, by immunizing rats with different susceptibility to disease (LEW.1 A, LEW.1F and DA rats). We found that nasal and tracheolaryngeal cartilage is affected in LEW.1 A and DA rats to varying degrees in collagen-induced arthritis but not in any strain in the pristane-induced model. Antibodies to matrilin-1, a cartilage-specific protein expressed mainly in tracheolaryngeal and nasal cartilage but not in joints, were positively associated with the presence of inflammation in nasal cartilage. In contrast, no antibody response to matrilin-1 could be detected in pristane-induced arthritis. In addition, nasal vaccination with collagen type II prior to immunization in DA rats significantly decreased the antibody response to matrilin-1 at day 56, but not at earlier time points, indicating a late protective effect on extra-articular cartilage. We conclude that pristane-induced arthritis is a joint-specific model whereas collagen-induced arthritis affect joints as well as extra-articular cartilage. Furthermore, collagen immunization induces an antibody response to matrilin-1.},
  author       = {Liedberg, Ann-Sofie and Lu, Shemin and Holmdahl, Rikard},
  issn         = {0009-9104},
  keyword      = {Collagen/*immunology,Disease Susceptibility,Extracellular Matrix Proteins/immunology,Glycoproteins/immunology,Immunosuppressive Agents/*immunology,Rats,Inbred Lew,Species Specificity,Support,Non-U.S. Gov't,Terpenes/*immunology,Articular/immunology/*pathology,Animal,Arthritis,Experimental/*immunology/*pathology,Autoantibodies/immunology,Cartilage},
  language     = {eng},
  number       = {1},
  pages        = {37--42},
  publisher    = {British Society for Immunology},
  series       = {Clinical and Experimental Immunology},
  title        = {Extra-articular cartilage affected in collagen-induced, but not pristane-induced, arthritis models.},
  url          = {http://dx.doi.org/10.1046/j.1365-2249.2002.01712.x},
  volume       = {127},
  year         = {2002},
}