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Sustained norepinephrine contraction in the rat portal vein is lost when Ca(2+) is replaced with Sr(2+).

Bonnevier, Johan LU ; Malmqvist, Ulf LU ; Sonntag, Dagmar; Schroeter, Mechthild; Nilsson, Holger; Pfitzer, Gabriele and Arner, Anders LU (2002) In American Journal of Physiology: Cell Physiology 282(4). p.845-852
Abstract
Agonist-induced activation of smooth muscle involves a rise in intracellular Ca(2+) concentration and sensitization of myosin light chain phosphorylation to Ca(2+). Sr(2+) can enter through Ca(2+) channels, be sequestered and released from sarcoplasmic reticulum, and replace Ca(2+) in activation of myosin light chain phosphorylation. Sr(2+) cannot replace Ca(2+) in facilitation of agonist-activated Ca(2+)-dependent nonselective cation channels. It is not known whether Sr(2+) can replace Ca(2+) in small G protein-mediated sensitization of phosphorylation. To explore mechanisms involved in alpha-receptor-activated contractions in smooth muscle, effects of replacing Ca(2+) with Sr(2+) were examined in rat portal vein. Norepinephrine (NE) at
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Smooth, Guanosine 5'-O-(3-Thiotriphosphate)/pharmacology, Muscle, Vascular/metabolism, Norepinephrine/*pharmacology, Portal Vein/*metabolism, Potassium/pharmacology, Rats, Sprague-Dawley, Support, Strontium/*pharmacokinetics, Non-U.S. Gov't, Vasoconstrictor Agents/*pharmacology, Vasoconstriction/drug effects/physiology, Female, Calcium/*pharmacokinetics, Animal
in
American Journal of Physiology: Cell Physiology
volume
282
issue
4
pages
845 - 852
publisher
American Physiological Society
external identifiers
  • pmid:11880273
  • wos:000174231300021
ISSN
1522-1563
DOI
10.1152/ajpcell.00191.2001
language
English
LU publication?
yes
id
385b97c7-8c49-4f43-bd98-e73458d5dc8d (old id 106292)
alternative location
http://ajpcell.physiology.org/cgi/content/abstract/282/4/C845
date added to LUP
2007-07-10 14:40:06
date last changed
2016-04-16 05:05:19
@article{385b97c7-8c49-4f43-bd98-e73458d5dc8d,
  abstract     = {Agonist-induced activation of smooth muscle involves a rise in intracellular Ca(2+) concentration and sensitization of myosin light chain phosphorylation to Ca(2+). Sr(2+) can enter through Ca(2+) channels, be sequestered and released from sarcoplasmic reticulum, and replace Ca(2+) in activation of myosin light chain phosphorylation. Sr(2+) cannot replace Ca(2+) in facilitation of agonist-activated Ca(2+)-dependent nonselective cation channels. It is not known whether Sr(2+) can replace Ca(2+) in small G protein-mediated sensitization of phosphorylation. To explore mechanisms involved in alpha-receptor-activated contractions in smooth muscle, effects of replacing Ca(2+) with Sr(2+) were examined in rat portal vein. Norepinephrine (NE) at},
  author       = {Bonnevier, Johan and Malmqvist, Ulf and Sonntag, Dagmar and Schroeter, Mechthild and Nilsson, Holger and Pfitzer, Gabriele and Arner, Anders},
  issn         = {1522-1563},
  keyword      = {Smooth,Guanosine 5'-O-(3-Thiotriphosphate)/pharmacology,Muscle,Vascular/metabolism,Norepinephrine/*pharmacology,Portal Vein/*metabolism,Potassium/pharmacology,Rats,Sprague-Dawley,Support,Strontium/*pharmacokinetics,Non-U.S. Gov't,Vasoconstrictor Agents/*pharmacology,Vasoconstriction/drug effects/physiology,Female,Calcium/*pharmacokinetics,Animal},
  language     = {eng},
  number       = {4},
  pages        = {845--852},
  publisher    = {American Physiological Society},
  series       = {American Journal of Physiology: Cell Physiology},
  title        = {Sustained norepinephrine contraction in the rat portal vein is lost when Ca(2+) is replaced with Sr(2+).},
  url          = {http://dx.doi.org/10.1152/ajpcell.00191.2001},
  volume       = {282},
  year         = {2002},
}