Enhanced expression of iNOS intratumorally and at the immunization site after immunization with IFNgamma-secreting rat glioma cells
Johansson, Anna C LU ; Hegardt, Pontus LU ; Janelidze, Shorena LU ; Visse, Edward LU ; Widegren, Bengt LU and Siesjö, Peter LU
(2002)
In Journal of Neuroimmunology
123(1-2).
p.135-143
- Abstract
Nitric oxide (NO) can modulate both tumor growth and antitumor immune responses. In order to elucidate the mechanism of curative therapeutic immunization with IFNgamma-producing glioma cells, we examined the expression of inducible nitric oxide synthase (iNOS) in tissue sections from immunized animals. There was a significantly enhanced iNOS expression both intratumorally and at the immunization site. Although the mechanisms behind this dual expression of iNOS most probably are different, our results suggest a role for NO in both the induction and execution of the antitumor response.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/106304
- author
- Johansson, Anna C
LU
; Hegardt, Pontus
LU
; Janelidze, Shorena
LU
; Visse, Edward
LU
; Widegren, Bengt
LU
and Siesjö, Peter
LU
- organization
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Cells, Cultured, Brain Neoplasms/*enzymology/immunology, Glioma/*immunology, Immunization, Interferon Type II/*biosynthesis, Lymph Nodes/enzymology, Male, Nitric Oxide/*physiology, Nitric-Oxide Synthase/*biosynthesis, Phagocytosis, Rats, Inbred F344, Skin/enzymology, Support, Non-U.S. Gov't, Spleen/enzymology, Animal
- in
- Journal of Neuroimmunology
- volume
- 123
- issue
- 1-2
- article number
- 123
- pages
- 9 pages
- publisher
- Elsevier
- external identifiers
-
- wos:000174761200016
- pmid:11880158
- scopus:0036190577
- pmid:11880158
- ISSN
- 1872-8421
- DOI
- 10.1016/S0165-5728(01)00468-4
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Neurosurgery (013026000), Genetics (Closed 2011) (011005100)
- id
- 27c8fad0-4ce3-4413-ad1f-1d5e47c747bc (old id 106304)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11880158&dopt=Abstract
- date added to LUP
- 2016-04-01 11:54:23
- date last changed
- 2025-10-14 13:10:21
@article{27c8fad0-4ce3-4413-ad1f-1d5e47c747bc,
abstract = {{<p>Nitric oxide (NO) can modulate both tumor growth and antitumor immune responses. In order to elucidate the mechanism of curative therapeutic immunization with IFNgamma-producing glioma cells, we examined the expression of inducible nitric oxide synthase (iNOS) in tissue sections from immunized animals. There was a significantly enhanced iNOS expression both intratumorally and at the immunization site. Although the mechanisms behind this dual expression of iNOS most probably are different, our results suggest a role for NO in both the induction and execution of the antitumor response.</p>}},
author = {{Johansson, Anna C and Hegardt, Pontus and Janelidze, Shorena and Visse, Edward and Widegren, Bengt and Siesjö, Peter}},
issn = {{1872-8421}},
keywords = {{Cells; Cultured; Brain Neoplasms/*enzymology/immunology; Glioma/*immunology; Immunization; Interferon Type II/*biosynthesis; Lymph Nodes/enzymology; Male; Nitric Oxide/*physiology; Nitric-Oxide Synthase/*biosynthesis; Phagocytosis; Rats; Inbred F344; Skin/enzymology; Support; Non-U.S. Gov't; Spleen/enzymology; Animal}},
language = {{eng}},
number = {{1-2}},
pages = {{135--143}},
publisher = {{Elsevier}},
series = {{Journal of Neuroimmunology}},
title = {{Enhanced expression of iNOS intratumorally and at the immunization site after immunization with IFNgamma-secreting rat glioma cells}},
url = {{http://dx.doi.org/10.1016/S0165-5728(01)00468-4}},
doi = {{10.1016/S0165-5728(01)00468-4}},
volume = {{123}},
year = {{2002}},
}