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Enhanced expression of iNOS intratumorally and at the immunization site after immunization with IFNγ-secreting rat glioma cells

Johansson, Anna LU ; Hegardt, Pontus LU ; Janelidze, Shorena LU ; Visse, Edward LU ; Widegren, Bengt LU and Siesjö, Peter LU (2002) In Journal of Neuroimmunology 123(1-2). p.135-143
Abstract
Nitric oxide (NO) can modulate both tumor growth and antitumor immune responses. In order to elucidate the mechanism of curative therapeutic immunization with IFNgamma-producing glioma cells, we examined the expression of inducible nitric oxide synthase (iNOS) in tissue sections from immunized animals. There was a significantly enhanced iNOS expression both intratumorally and at the immunization site. Although the mechanisms behind this dual expression of iNOS most probably are different, our results suggest a role for NO in both the induction and execution of the antitumor response.
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cells, Cultured, Brain Neoplasms/*enzymology/immunology, Glioma/*immunology, Immunization, Interferon Type II/*biosynthesis, Lymph Nodes/enzymology, Male, Nitric Oxide/*physiology, Nitric-Oxide Synthase/*biosynthesis, Phagocytosis, Rats, Inbred F344, Skin/enzymology, Support, Non-U.S. Gov't, Spleen/enzymology, Animal
in
Journal of Neuroimmunology
volume
123
issue
1-2
pages
9 pages
publisher
Elsevier
external identifiers
  • wos:000174761200016
  • pmid:11880158
  • scopus:0036190577
ISSN
1872-8421
DOI
10.1016/S0165-5728(01)00468-4http://dx.doi.org/10.1016/S0165-5728(01)00468-4
language
English
LU publication?
yes
id
27c8fad0-4ce3-4413-ad1f-1d5e47c747bc (old id 106304)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11880158&dopt=Abstract
date added to LUP
2007-07-16 09:11:37
date last changed
2017-08-13 03:34:13
@article{27c8fad0-4ce3-4413-ad1f-1d5e47c747bc,
  abstract     = {Nitric oxide (NO) can modulate both tumor growth and antitumor immune responses. In order to elucidate the mechanism of curative therapeutic immunization with IFNgamma-producing glioma cells, we examined the expression of inducible nitric oxide synthase (iNOS) in tissue sections from immunized animals. There was a significantly enhanced iNOS expression both intratumorally and at the immunization site. Although the mechanisms behind this dual expression of iNOS most probably are different, our results suggest a role for NO in both the induction and execution of the antitumor response.},
  articleno    = {123},
  author       = {Johansson, Anna and Hegardt, Pontus and Janelidze, Shorena and Visse, Edward and Widegren, Bengt and Siesjö, Peter},
  issn         = {1872-8421},
  keyword      = {Cells,Cultured,Brain Neoplasms/*enzymology/immunology,Glioma/*immunology,Immunization,Interferon Type II/*biosynthesis,Lymph Nodes/enzymology,Male,Nitric Oxide/*physiology,Nitric-Oxide Synthase/*biosynthesis,Phagocytosis,Rats,Inbred F344,Skin/enzymology,Support,Non-U.S. Gov't,Spleen/enzymology,Animal},
  language     = {eng},
  number       = {1-2},
  pages        = {135--143},
  publisher    = {Elsevier},
  series       = {Journal of Neuroimmunology},
  title        = {Enhanced expression of iNOS intratumorally and at the immunization site after immunization with IFNγ-secreting rat glioma cells},
  url          = {http://dx.doi.org/10.1016/S0165-5728(01)00468-4http://dx.doi.org/10.1016/S0165-5728(01)00468-4},
  volume       = {123},
  year         = {2002},
}