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Platelet concentrate increases bone ingrowth into porous hydroxyapatite.

Siebrecht, Maikel A N; De Rooij, Philippe P; Arm, Douglas M; Olsson, Martin L and Aspenberg, Per LU (2002) In Orthopedics 25(2). p.72-169
Abstract
Platelets contain growth factors that are believed to stimulate early fracture repair. Autologous platelets can be sequestered, concentrated, and mixed with thrombin to yield a so-called autologous growth factor gel, which might enhance bone repair or bone graft incorporation. The effect of this platelet concentrate on total tissue and bone ingrowth into porous coralline hydroxyapatite was studied in a bone chamber rat model. Chambers with the platelet concentrate showed a significant increase in bone and total tissue ingrowth distance compared to untreated controls, indicating a platelet concentrate might enhance the clinical performance of porous hydroxyapatite in bone replacement.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Orthopedics
volume
25
issue
2
pages
72 - 169
publisher
Slack Inc
external identifiers
  • scopus:0036184972
ISSN
1938-2367
language
English
LU publication?
yes
id
35381e66-92fe-4519-bf88-e8187a6a77d1 (old id 106604)
alternative location
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=11871379&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
date added to LUP
2007-07-04 09:21:31
date last changed
2017-04-02 03:27:25
@article{35381e66-92fe-4519-bf88-e8187a6a77d1,
  abstract     = {Platelets contain growth factors that are believed to stimulate early fracture repair. Autologous platelets can be sequestered, concentrated, and mixed with thrombin to yield a so-called autologous growth factor gel, which might enhance bone repair or bone graft incorporation. The effect of this platelet concentrate on total tissue and bone ingrowth into porous coralline hydroxyapatite was studied in a bone chamber rat model. Chambers with the platelet concentrate showed a significant increase in bone and total tissue ingrowth distance compared to untreated controls, indicating a platelet concentrate might enhance the clinical performance of porous hydroxyapatite in bone replacement.},
  author       = {Siebrecht, Maikel A N and De Rooij, Philippe P and Arm, Douglas M and Olsson, Martin L and Aspenberg, Per},
  issn         = {1938-2367},
  language     = {eng},
  number       = {2},
  pages        = {72--169},
  publisher    = {Slack Inc},
  series       = {Orthopedics},
  title        = {Platelet concentrate increases bone ingrowth into porous hydroxyapatite.},
  volume       = {25},
  year         = {2002},
}