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Insulin-like growth factor II plays a central role in atherosclerosis in a mouse model.

Zaina, Silvio LU ; Pettersson, Linda; Ahrén, Bo LU ; Brånén, Lena LU ; Hassan, A Bassim; Lindholm, Marie LU ; Mattsson, Ragnar; Thyberg, Johan and Nilsson, Jan LU (2002) In Journal of Biological Chemistry 277(6). p.4505-4511
Abstract
Insulin-like growth factor II is a fetal promoter of cell proliferation that is involved in some forms of cancer and overgrowth syndromes in humans. Here, we provide two sources of genetic evidence for a novel, pivotal role of locally produced insulin-like growth factor II in the development of atherosclerosis. First, we show that homozygosity for a disrupted insulin-like growth factor II allele in mice lacking apolipoprotein E, a widely used animal model of atherosclerosis, results in aortic lesions that are approximately 80% smaller and contain approximately 50% less proliferating cells compared with mice lacking only apolipoprotein E. Second, targeted expression of an insulin-like growth factor II transgene in smooth muscle cells, but... (More)
Insulin-like growth factor II is a fetal promoter of cell proliferation that is involved in some forms of cancer and overgrowth syndromes in humans. Here, we provide two sources of genetic evidence for a novel, pivotal role of locally produced insulin-like growth factor II in the development of atherosclerosis. First, we show that homozygosity for a disrupted insulin-like growth factor II allele in mice lacking apolipoprotein E, a widely used animal model of atherosclerosis, results in aortic lesions that are approximately 80% smaller and contain approximately 50% less proliferating cells compared with mice lacking only apolipoprotein E. Second, targeted expression of an insulin-like growth factor II transgene in smooth muscle cells, but not the mere elevation of circulating levels of the peptide, causes per se aortic focal intimal thickenings. The insulin-like growth factor II transgenics presented here are the first viable mutant mice spontaneously developing intimal masses. These observations provide the first direct evidence for an atherogenic activity of insulin-like growth factor II in vivo. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Animal, Pathology, Ultrastructure, Arteriosclerosis, Disease Models, Transgenes, Aorta
in
Journal of Biological Chemistry
volume
277
issue
6
pages
4505 - 4511
publisher
ASBMB
external identifiers
  • wos:000173813900093
  • pmid:11726660
  • scopus:0037040247
ISSN
1083-351X
DOI
10.1074/jbc.M108061200
language
English
LU publication?
yes
id
2ab13cba-2b44-4f20-9b7c-bc6d382b29b6 (old id 107055)
alternative location
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11726660&dopt=Abstract
date added to LUP
2007-07-02 09:56:38
date last changed
2017-09-03 03:38:13
@article{2ab13cba-2b44-4f20-9b7c-bc6d382b29b6,
  abstract     = {Insulin-like growth factor II is a fetal promoter of cell proliferation that is involved in some forms of cancer and overgrowth syndromes in humans. Here, we provide two sources of genetic evidence for a novel, pivotal role of locally produced insulin-like growth factor II in the development of atherosclerosis. First, we show that homozygosity for a disrupted insulin-like growth factor II allele in mice lacking apolipoprotein E, a widely used animal model of atherosclerosis, results in aortic lesions that are approximately 80% smaller and contain approximately 50% less proliferating cells compared with mice lacking only apolipoprotein E. Second, targeted expression of an insulin-like growth factor II transgene in smooth muscle cells, but not the mere elevation of circulating levels of the peptide, causes per se aortic focal intimal thickenings. The insulin-like growth factor II transgenics presented here are the first viable mutant mice spontaneously developing intimal masses. These observations provide the first direct evidence for an atherogenic activity of insulin-like growth factor II in vivo.},
  author       = {Zaina, Silvio and Pettersson, Linda and Ahrén, Bo and Brånén, Lena and Hassan, A Bassim and Lindholm, Marie and Mattsson, Ragnar and Thyberg, Johan and Nilsson, Jan},
  issn         = {1083-351X},
  keyword      = {Animal,Pathology,Ultrastructure,Arteriosclerosis,Disease Models,Transgenes,Aorta},
  language     = {eng},
  number       = {6},
  pages        = {4505--4511},
  publisher    = {ASBMB},
  series       = {Journal of Biological Chemistry},
  title        = {Insulin-like growth factor II plays a central role in atherosclerosis in a mouse model.},
  url          = {http://dx.doi.org/10.1074/jbc.M108061200},
  volume       = {277},
  year         = {2002},
}