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Metabolic engineering of Saccharomyces cerevisiae for xylose utilization.

Hahn-Hägerdal, Bärbel LU ; Wahlbom, Fredrik LU ; Gárdonyi, Márk LU ; van Zyl, W H; Cordero Otero, R R and Jönsson, L J (2001) In Advances in Biochemical Engineering, Biotechnology 73. p.53-84
Abstract
Metabolic engineering of Saccharomyces cerevisiae for ethanolic fermentation of xylose is summarized with emphasis on progress made during the last decade. Advances in xylose transport, initial xylose metabolism, selection of host strains, transformation and classical breeding techniques applied to industrial polyploid strains as well as modeling of xylose metabolism are discussed. The production and composition of the substrates--lignocellulosic hydrolysates--is briefly summarized. In a future outlook iterative strategies involving the techniques of classical breeding, quantitative physiology, proteomics, DNA micro arrays, and genetic engineering are proposed for the development of efficient xylose-fermenting recombinant strains of S.... (More)
Metabolic engineering of Saccharomyces cerevisiae for ethanolic fermentation of xylose is summarized with emphasis on progress made during the last decade. Advances in xylose transport, initial xylose metabolism, selection of host strains, transformation and classical breeding techniques applied to industrial polyploid strains as well as modeling of xylose metabolism are discussed. The production and composition of the substrates--lignocellulosic hydrolysates--is briefly summarized. In a future outlook iterative strategies involving the techniques of classical breeding, quantitative physiology, proteomics, DNA micro arrays, and genetic engineering are proposed for the development of efficient xylose-fermenting recombinant strains of S. cerevisiae. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Hexoses : metabolism, Xylulose : metabolism, Xylose : metabolism, Support, Non-U.S. Gov't, Saccharomyces cerevisiae : metabolism, Biological Transport, Fermentation, Pentoses : metabolism
in
Advances in Biochemical Engineering, Biotechnology
volume
73
pages
53 - 84
publisher
Springer
external identifiers
  • scopus:0035233593
ISSN
0724-6145
language
English
LU publication?
yes
id
994c0d35-ad02-4f07-ab79-1d236139d655 (old id 107083)
alternative location
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11816812&dopt=Abstract
date added to LUP
2007-06-28 13:24:38
date last changed
2018-01-07 09:03:02
@article{994c0d35-ad02-4f07-ab79-1d236139d655,
  abstract     = {Metabolic engineering of Saccharomyces cerevisiae for ethanolic fermentation of xylose is summarized with emphasis on progress made during the last decade. Advances in xylose transport, initial xylose metabolism, selection of host strains, transformation and classical breeding techniques applied to industrial polyploid strains as well as modeling of xylose metabolism are discussed. The production and composition of the substrates--lignocellulosic hydrolysates--is briefly summarized. In a future outlook iterative strategies involving the techniques of classical breeding, quantitative physiology, proteomics, DNA micro arrays, and genetic engineering are proposed for the development of efficient xylose-fermenting recombinant strains of S. cerevisiae.},
  author       = {Hahn-Hägerdal, Bärbel and Wahlbom, Fredrik and Gárdonyi, Márk and van Zyl, W H and Cordero Otero, R R and Jönsson, L J},
  issn         = {0724-6145},
  keyword      = {Hexoses : metabolism,Xylulose : metabolism,Xylose : metabolism,Support,Non-U.S. Gov't,Saccharomyces cerevisiae : metabolism,Biological Transport,Fermentation,Pentoses : metabolism},
  language     = {eng},
  pages        = {53--84},
  publisher    = {Springer},
  series       = {Advances in Biochemical Engineering, Biotechnology},
  title        = {Metabolic engineering of Saccharomyces cerevisiae for xylose utilization.},
  volume       = {73},
  year         = {2001},
}