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Proteolysis and its regulation at the surface of Streptococcus pyogenes.

Rasmussen, Magnus LU and Björck, Lars LU (2002) In Molecular Microbiology 43(3). p.537-544
Abstract
Pathogenic bacteria often produce proteinases that are believed to be involved in virulence. Moreover, several host defence systems depend on proteolysis, demonstrating that proteolysis and its regulation play an important role during bacterial infections. Here, we discuss how proteolytical events are regulated at the surface of Streptococcus pyogenes during infection with this important human pathogen. Streptococcus pyogenes produces proteinases, and host proteinases are produced and released as a result of the infection. Streptococcus pyogenes also recruits host proteinase inhibitors to its surface, suggesting that proteolysis is tightly regulated at the bacterial surface. We propose that the initial phase of a S. pyogenes infection is... (More)
Pathogenic bacteria often produce proteinases that are believed to be involved in virulence. Moreover, several host defence systems depend on proteolysis, demonstrating that proteolysis and its regulation play an important role during bacterial infections. Here, we discuss how proteolytical events are regulated at the surface of Streptococcus pyogenes during infection with this important human pathogen. Streptococcus pyogenes produces proteinases, and host proteinases are produced and released as a result of the infection. Streptococcus pyogenes also recruits host proteinase inhibitors to its surface, suggesting that proteolysis is tightly regulated at the bacterial surface. We propose that the initial phase of a S. pyogenes infection is characterized by inhibition of proteolysis and complement activity at the bacterial surface. This is achieved mainly through binding of host proteinase inhibitors and complement regulatory proteins to bacterial surface proteins. In a later phase of the infection, massive proteolytic activity will release bacterial surface proteins and degrade human tissues, thus facilitating bacterial spread. These proteolytic events are regulated both temporally and spatially, and should influence virulence and the outcome of S. pyogenes infections. (Less)
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Contribution to journal
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published
subject
keywords
Complement Activation, Cell Membrane : metabolism, Enzymes : metabolism, Human, Streptococcal Infections : metabolism, Plasmin : metabolism, Streptococcal Infections : microbiology, Streptococcus pyogenes : metabolism, Streptococcus pyogenes : pathogenicity, Support, Non-U.S. Gov't, Bacterial Proteins : metabolism
in
Molecular Microbiology
volume
43
issue
3
pages
537 - 544
publisher
Wiley-Blackwell
external identifiers
  • wos:000174058300001
  • pmid:11929513
  • scopus:0036271592
ISSN
1365-2958
DOI
10.1046/j.1365-2958.2002.02766.x
language
English
LU publication?
yes
id
fc54779d-1ab7-43c8-a62f-9d64cdaf08c3 (old id 107355)
alternative location
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11929513&dopt=Abstract
date added to LUP
2007-07-05 09:48:13
date last changed
2017-12-10 03:53:05
@article{fc54779d-1ab7-43c8-a62f-9d64cdaf08c3,
  abstract     = {Pathogenic bacteria often produce proteinases that are believed to be involved in virulence. Moreover, several host defence systems depend on proteolysis, demonstrating that proteolysis and its regulation play an important role during bacterial infections. Here, we discuss how proteolytical events are regulated at the surface of Streptococcus pyogenes during infection with this important human pathogen. Streptococcus pyogenes produces proteinases, and host proteinases are produced and released as a result of the infection. Streptococcus pyogenes also recruits host proteinase inhibitors to its surface, suggesting that proteolysis is tightly regulated at the bacterial surface. We propose that the initial phase of a S. pyogenes infection is characterized by inhibition of proteolysis and complement activity at the bacterial surface. This is achieved mainly through binding of host proteinase inhibitors and complement regulatory proteins to bacterial surface proteins. In a later phase of the infection, massive proteolytic activity will release bacterial surface proteins and degrade human tissues, thus facilitating bacterial spread. These proteolytic events are regulated both temporally and spatially, and should influence virulence and the outcome of S. pyogenes infections.},
  author       = {Rasmussen, Magnus and Björck, Lars},
  issn         = {1365-2958},
  keyword      = {Complement Activation,Cell Membrane : metabolism,Enzymes : metabolism,Human,Streptococcal Infections : metabolism,Plasmin : metabolism,Streptococcal Infections : microbiology,Streptococcus pyogenes : metabolism,Streptococcus pyogenes : pathogenicity,Support,Non-U.S. Gov't,Bacterial Proteins : metabolism},
  language     = {eng},
  number       = {3},
  pages        = {537--544},
  publisher    = {Wiley-Blackwell},
  series       = {Molecular Microbiology},
  title        = {Proteolysis and its regulation at the surface of Streptococcus pyogenes.},
  url          = {http://dx.doi.org/10.1046/j.1365-2958.2002.02766.x},
  volume       = {43},
  year         = {2002},
}