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Reduction of instability-induced bone resorption using bisphosphonates: high doses are needed in rats.

Åstrand, Jörgen LU and Aspenberg, Per LU (2002) In Acta Orthopaedica Scandinavica 73(1). p.24-30
Abstract
Bone resorption associated with prosthetic loosening can be reduced by giving bisphosphonates since they bind to bone surfaces and inactivate osteoclasts when bisphosphonate-containing bone is resorbed. During loosening, an increase in osteoclastic activity can be triggered by mechanical instability, fluid pressure or wear particles. We used a rat model in which a titanium surface can be made to slide over a bone surface and cause instability-induced bone resorption. 111 rats were operated on with a plate implant and treated with alendronate or clodronate injections in different doses or saline controls. After 4 weeks of osseointegration, the plate was moved during 2 weeks and the findings evaluated with histomorphometry. The percentage of... (More)
Bone resorption associated with prosthetic loosening can be reduced by giving bisphosphonates since they bind to bone surfaces and inactivate osteoclasts when bisphosphonate-containing bone is resorbed. During loosening, an increase in osteoclastic activity can be triggered by mechanical instability, fluid pressure or wear particles. We used a rat model in which a titanium surface can be made to slide over a bone surface and cause instability-induced bone resorption. 111 rats were operated on with a plate implant and treated with alendronate or clodronate injections in different doses or saline controls. After 4 weeks of osseointegration, the plate was moved during 2 weeks and the findings evaluated with histomorphometry. The percentage of persisting bone-metal contact and the soft tissue area at the interface were measured to estimate bone loss. Low or intermediate doses of the bisphosphonates increased the ash weight of untraumatized bone, but did not inhibit resorption at the unstable interface. Only rats treated with the highest doses of alendronate or clodronate had more bone-metal contact than controls. Instability-induced bone resorption therefore seems to be reduced by bisphosphonates, but higher doses are needed to obtain this effect than to reduce bone resorption associated with normal remodeling of untraumatized bone. (Less)
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keywords
Dose-Response Relationship, Animal, Drug, Immunohistochemistry, Joint Instability : prevention & control, Male, Osseointegration : drug effects, Preoperative Care : methods, Prostheses and Implants, Probability, Rats, Wistar, Reference Values, Sensitivity and Specificity, Statistics, Nonparametric, Support, Non-U.S. Gov't, Tibia : surgery, Disease Models, Diphosphonates : pharmacology, Bone Resorption : prevention & control, Clodronic Acid : pharmacology, Bone Plates, Alendronate : pharmacology
in
Acta Orthopaedica Scandinavica
volume
73
issue
1
pages
24 - 30
publisher
Taylor & Francis
external identifiers
  • wos:000174411800006
  • pmid:11928907
  • scopus:0036121776
ISSN
0001-6470
DOI
10.1080/000164702317281369
language
English
LU publication?
yes
id
9d5af3ab-1a14-4e35-8029-3d8785834b14 (old id 107362)
alternative location
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11928907&dopt=Abstract
date added to LUP
2007-07-03 09:57:39
date last changed
2017-12-10 04:33:56
@article{9d5af3ab-1a14-4e35-8029-3d8785834b14,
  abstract     = {Bone resorption associated with prosthetic loosening can be reduced by giving bisphosphonates since they bind to bone surfaces and inactivate osteoclasts when bisphosphonate-containing bone is resorbed. During loosening, an increase in osteoclastic activity can be triggered by mechanical instability, fluid pressure or wear particles. We used a rat model in which a titanium surface can be made to slide over a bone surface and cause instability-induced bone resorption. 111 rats were operated on with a plate implant and treated with alendronate or clodronate injections in different doses or saline controls. After 4 weeks of osseointegration, the plate was moved during 2 weeks and the findings evaluated with histomorphometry. The percentage of persisting bone-metal contact and the soft tissue area at the interface were measured to estimate bone loss. Low or intermediate doses of the bisphosphonates increased the ash weight of untraumatized bone, but did not inhibit resorption at the unstable interface. Only rats treated with the highest doses of alendronate or clodronate had more bone-metal contact than controls. Instability-induced bone resorption therefore seems to be reduced by bisphosphonates, but higher doses are needed to obtain this effect than to reduce bone resorption associated with normal remodeling of untraumatized bone.},
  author       = {Åstrand, Jörgen and Aspenberg, Per},
  issn         = {0001-6470},
  keyword      = {Dose-Response Relationship,Animal,Drug,Immunohistochemistry,Joint Instability : prevention & control,Male,Osseointegration : drug effects,Preoperative Care : methods,Prostheses and Implants,Probability,Rats,Wistar,Reference Values,Sensitivity and Specificity,Statistics,Nonparametric,Support,Non-U.S. Gov't,Tibia : surgery,Disease Models,Diphosphonates : pharmacology,Bone Resorption : prevention & control,Clodronic Acid : pharmacology,Bone Plates,Alendronate : pharmacology},
  language     = {eng},
  number       = {1},
  pages        = {24--30},
  publisher    = {Taylor & Francis},
  series       = {Acta Orthopaedica Scandinavica},
  title        = {Reduction of instability-induced bone resorption using bisphosphonates: high doses are needed in rats.},
  url          = {http://dx.doi.org/10.1080/000164702317281369},
  volume       = {73},
  year         = {2002},
}