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Incidence of cardiovascular disease, cancer and death in postmenopausal women affirming use of hormone replacement therapy.

Hedblad, Bo LU ; Merlo, Juan LU ; Manjer, Jonas LU ; Engström, Gunnar LU ; Berglund, Göran LU and Janzon, Lars LU (2002) In Scandinavian Journal of Public Health1999-01-01+01:00 30(1). p.12-19
Abstract
AIM: The goal of this study was to evaluate the incidence of myocardial infarction, cancer and death in relation to use of hormone replacement therapy (HRT). METHODS: Nine years' follow up of an urban cohort of peri-/postmenopausal women was undertaken. Local and national registers were used for retrieval of events. RESULTS: The incidence of myocardial infarction per 1.000 person-years in users and non-users was 0.61 (5/962) and 2.20 (92/4759) respectively, adjusted relative risk (RR) 0.37; 95% confidence interval 0.15-0.90. Rates of mortality from cardiovascular disease and cancer were 0.36 and 1.10, p= 0.058, and 2.60 and 2.09, p=0.360 respectively. In terms of all-cause mortality the adjusted RR was 1.02; 0.69-1.52, incidence of cancer... (More)
AIM: The goal of this study was to evaluate the incidence of myocardial infarction, cancer and death in relation to use of hormone replacement therapy (HRT). METHODS: Nine years' follow up of an urban cohort of peri-/postmenopausal women was undertaken. Local and national registers were used for retrieval of events. RESULTS: The incidence of myocardial infarction per 1.000 person-years in users and non-users was 0.61 (5/962) and 2.20 (92/4759) respectively, adjusted relative risk (RR) 0.37; 95% confidence interval 0.15-0.90. Rates of mortality from cardiovascular disease and cancer were 0.36 and 1.10, p= 0.058, and 2.60 and 2.09, p=0.360 respectively. In terms of all-cause mortality the adjusted RR was 1.02; 0.69-1.52, incidence of cancer 1.28; 1.01-1.64, breast cancer 1.52; 1.01-2.28 and endometrial cancer 3.61; 1.54-8.46. CONCLUSIONS: Women affirming use of HRT had a lower incidence of myocardial infarction. Further studies are needed to assess whether the absence of effect on total mortality may be accounted for by an increased cancer risk. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Scandinavian Journal of Public Health1999-01-01+01:00
volume
30
issue
1
pages
12 - 19
publisher
Taylor & Francis
external identifiers
  • pmid:11928828
  • wos:000174640600003
  • scopus:0036364873
ISSN
1651-1905
DOI
10.1080/140349401753481538
language
English
LU publication?
yes
id
cecfb669-41d4-4eb3-bbba-5611c587e9d4 (old id 107366)
date added to LUP
2007-07-23 14:16:25
date last changed
2017-01-01 07:05:12
@article{cecfb669-41d4-4eb3-bbba-5611c587e9d4,
  abstract     = {AIM: The goal of this study was to evaluate the incidence of myocardial infarction, cancer and death in relation to use of hormone replacement therapy (HRT). METHODS: Nine years' follow up of an urban cohort of peri-/postmenopausal women was undertaken. Local and national registers were used for retrieval of events. RESULTS: The incidence of myocardial infarction per 1.000 person-years in users and non-users was 0.61 (5/962) and 2.20 (92/4759) respectively, adjusted relative risk (RR) 0.37; 95% confidence interval 0.15-0.90. Rates of mortality from cardiovascular disease and cancer were 0.36 and 1.10, p= 0.058, and 2.60 and 2.09, p=0.360 respectively. In terms of all-cause mortality the adjusted RR was 1.02; 0.69-1.52, incidence of cancer 1.28; 1.01-1.64, breast cancer 1.52; 1.01-2.28 and endometrial cancer 3.61; 1.54-8.46. CONCLUSIONS: Women affirming use of HRT had a lower incidence of myocardial infarction. Further studies are needed to assess whether the absence of effect on total mortality may be accounted for by an increased cancer risk.},
  author       = {Hedblad, Bo and Merlo, Juan and Manjer, Jonas and Engström, Gunnar and Berglund, Göran and Janzon, Lars},
  issn         = {1651-1905},
  language     = {eng},
  number       = {1},
  pages        = {12--19},
  publisher    = {Taylor & Francis},
  series       = {Scandinavian Journal of Public Health1999-01-01+01:00},
  title        = {Incidence of cardiovascular disease, cancer and death in postmenopausal women affirming use of hormone replacement therapy.},
  url          = {http://dx.doi.org/10.1080/140349401753481538},
  volume       = {30},
  year         = {2002},
}