Advanced

Risk factors for developing systemic lupus erythematosus: a case-control study in southern Sweden.

Bengtsson, A A; Rylander, Lars LU ; Hagmar, L; Nived, Ola LU and Sturfelt, Gunnar LU (2002) In Rheumatology1999-01-01+01:00 41(5). p.563-571
Abstract
OBJECTIVE: To explore the risk factors that have been suggested to be associated with the development of SLE. METHODS: A case-control study was performed and a questionnaire was developed to obtain the data. Consecutive female incident cases diagnosed between 1981 and 1999 in a defined geographical area in southern Sweden were included. Controls, matched for calendar year of birth, were selected randomly from the same area. In total, 85 cases and 205 controls agreed to participate. The questionnaire included questions about formal education, body weight and height, medical history, family history of autoimmune diseases, exposure to ultraviolet radiation, animals, hair-colouring dyes, alfalfa (lucerne) sprouts, smoking and alcohol habits,... (More)
OBJECTIVE: To explore the risk factors that have been suggested to be associated with the development of SLE. METHODS: A case-control study was performed and a questionnaire was developed to obtain the data. Consecutive female incident cases diagnosed between 1981 and 1999 in a defined geographical area in southern Sweden were included. Controls, matched for calendar year of birth, were selected randomly from the same area. In total, 85 cases and 205 controls agreed to participate. The questionnaire included questions about formal education, body weight and height, medical history, family history of autoimmune diseases, exposure to ultraviolet radiation, animals, hair-colouring dyes, alfalfa (lucerne) sprouts, smoking and alcohol habits, history of physical traumata, blood transfusion, silicone breast implants, exogenous oestrogens, other medication, and significant negative life events. RESULTS: Using a multivariate model, a history of hypertension [odds ratio (OR)=3.7, 95% confidence interval (CI) 1.4-9.8], drug allergy (OR=3.6, 95% CI 1.4-9.5), a type I/II sun-reactive skin type (OR=2.3, 95% CI 1.1-4.8) and a family history of SLE (OR=6.8, 95% CI 1.4-32) were all significantly associated with an increased risk of developing SLE, whereas consumption of alcohol was inversely associated with the risk of SLE (use of alcohol very seldom, OR=1.0; 1-150 g/month, OR=0.4, 95% CI 0.2-1.0; >150 g/month, OR=0.2, 95% CI 0.1-0.5). A suggested association with increased SLE risk was seen for smoking (OR=1.8, 95% CI 0.9-3.6) and blood transfusions (OR=2.3, 95% CI 0.9-5.8). Neither exposure to exogenous oestrogen nor exposure to hair-colouring dyes was associated with SLE. CONCLUSIONS: Risk factors of both exogenous and endogenous origin were identified in this population-based series of SLE patients. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Case-Control Studies, Female, Human, Lupus Erythematosus, Middle Age, Systemic : epidemiology, Multivariate Analysis, Odds Ratio, Questionnaires, Random Allocation, Risk Factors, Sweden : epidemiology, Support, Non-U.S. Gov't, Adolescence, Adult, 80 and over, Aged
in
Rheumatology1999-01-01+01:00
volume
41
issue
5
pages
563 - 571
publisher
Oxford University Press
external identifiers
  • pmid:12011382
  • wos:000175805100015
  • scopus:0036266505
ISSN
1462-0332
DOI
10.1093/rheumatology/41.5.563
language
English
LU publication?
yes
id
f947a2c1-6228-4b60-9625-8a8662deb5dd (old id 108262)
alternative location
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12011382&dopt=Abstract
date added to LUP
2007-07-04 11:57:13
date last changed
2017-11-19 04:07:27
@article{f947a2c1-6228-4b60-9625-8a8662deb5dd,
  abstract     = {OBJECTIVE: To explore the risk factors that have been suggested to be associated with the development of SLE. METHODS: A case-control study was performed and a questionnaire was developed to obtain the data. Consecutive female incident cases diagnosed between 1981 and 1999 in a defined geographical area in southern Sweden were included. Controls, matched for calendar year of birth, were selected randomly from the same area. In total, 85 cases and 205 controls agreed to participate. The questionnaire included questions about formal education, body weight and height, medical history, family history of autoimmune diseases, exposure to ultraviolet radiation, animals, hair-colouring dyes, alfalfa (lucerne) sprouts, smoking and alcohol habits, history of physical traumata, blood transfusion, silicone breast implants, exogenous oestrogens, other medication, and significant negative life events. RESULTS: Using a multivariate model, a history of hypertension [odds ratio (OR)=3.7, 95% confidence interval (CI) 1.4-9.8], drug allergy (OR=3.6, 95% CI 1.4-9.5), a type I/II sun-reactive skin type (OR=2.3, 95% CI 1.1-4.8) and a family history of SLE (OR=6.8, 95% CI 1.4-32) were all significantly associated with an increased risk of developing SLE, whereas consumption of alcohol was inversely associated with the risk of SLE (use of alcohol very seldom, OR=1.0; 1-150 g/month, OR=0.4, 95% CI 0.2-1.0; >150 g/month, OR=0.2, 95% CI 0.1-0.5). A suggested association with increased SLE risk was seen for smoking (OR=1.8, 95% CI 0.9-3.6) and blood transfusions (OR=2.3, 95% CI 0.9-5.8). Neither exposure to exogenous oestrogen nor exposure to hair-colouring dyes was associated with SLE. CONCLUSIONS: Risk factors of both exogenous and endogenous origin were identified in this population-based series of SLE patients.},
  author       = {Bengtsson, A A and Rylander, Lars and Hagmar, L and Nived, Ola and Sturfelt, Gunnar},
  issn         = {1462-0332},
  keyword      = {Case-Control Studies,Female,Human,Lupus Erythematosus,Middle Age,Systemic : epidemiology,Multivariate Analysis,Odds Ratio,Questionnaires,Random Allocation,Risk Factors,Sweden : epidemiology,Support,Non-U.S. Gov't,Adolescence,Adult,80 and over,Aged},
  language     = {eng},
  number       = {5},
  pages        = {563--571},
  publisher    = {Oxford University Press},
  series       = {Rheumatology1999-01-01+01:00},
  title        = {Risk factors for developing systemic lupus erythematosus: a case-control study in southern Sweden.},
  url          = {http://dx.doi.org/10.1093/rheumatology/41.5.563},
  volume       = {41},
  year         = {2002},
}