Advanced

Increased autoantibodies to SOX13 in Swedish patients with type 1 diabetes.

Törn, Carina LU ; Shtauvere-Brameus, A; Sanjeevi, C B and Landin-Olsson, Mona LU (2002) In Annals of the New York Academy of Sciences 958. p.218-223
Abstract
This article aims to estimate the prevalence of SOX13 antibodies in Swedish patients with type 1 diabetes and healthy controls. The patients (n = 102; median age 35 years [range, 9-89]) were newly diagnosed with type 1 diabetes in a defined area in southern Sweden during 1995-1998. Islet cell antibodies (ICA) were analyzed with immunofluorescence, while glutamic acid decarboxylase antibodies (GADA), tyrosine phosphatase antibodies (IA-2A), and antibodies against the transcription factor SOX13 (SOX13Ab) were analyzed with radioimmunoprecipitating assays. SOX13Ab were found in 9.8% (10/102) of type 1 patients compared to 2.0% (2/99) in healthy controls (P = 0.033). At least one of the four autoantibodies (ICA, GADA, IA-2A or SOX13Ab) were... (More)
This article aims to estimate the prevalence of SOX13 antibodies in Swedish patients with type 1 diabetes and healthy controls. The patients (n = 102; median age 35 years [range, 9-89]) were newly diagnosed with type 1 diabetes in a defined area in southern Sweden during 1995-1998. Islet cell antibodies (ICA) were analyzed with immunofluorescence, while glutamic acid decarboxylase antibodies (GADA), tyrosine phosphatase antibodies (IA-2A), and antibodies against the transcription factor SOX13 (SOX13Ab) were analyzed with radioimmunoprecipitating assays. SOX13Ab were found in 9.8% (10/102) of type 1 patients compared to 2.0% (2/99) in healthy controls (P = 0.033). At least one of the four autoantibodies (ICA, GADA, IA-2A or SOX13Ab) were identified in 67% (68/102) of the patients. Samples positive for IA-2A were only in one case positive also for SOX13Ab. IA-2A-positive patients were often positive also for ICA and GADA (19/27), and the same combination was also common for SOX13Ab-positive patients (6/10). Only 2.0% (2/102) were positive for SOX13Ab alone. ICA, GADA and IA-2A were more frequent in younger patients (<or= 35 years of age) than in older patients, while SOX13Ab showed similar frequency in both groups. We concluded that the frequency of SOX13Ab was significantly increased in Swedish patients with type 1 diabetes, but that the addition of SOX13Ab to the combination of GADA and IA2-A only increased the sensitivity by 2% for autoimmune diabetes. Therefore, SOX13 could be a minor autoantigen involved in the pathogenesis of type 1 diabetes. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Diabetes Mellitus, Child, Autoantigens : immunology, Autoantigens : blood, Autoantibodies : immunology, Autoantibodies : blood, Aging : immunology, 80 and over, Aged, Adult, Adolescence, High Mobility Group Proteins : blood, High Mobility Group Proteins : immunology, Human, Middle Age, Support, Non-U.S. Gov't, Sweden : epidemiology, Insulin-Dependent : epidemiology, Insulin-Dependent : immunology
in
Annals of the New York Academy of Sciences
volume
958
pages
218 - 223
publisher
New York Academy of Sciences
external identifiers
  • wos:000176952100034
  • pmid:12021110
  • scopus:0036271306
ISSN
0077-8923
DOI
10.1111/j.1749-6632.2002.tb02973
language
English
LU publication?
yes
id
b70deb06-52b3-4814-9a22-45a65523f17b (old id 108329)
alternative location
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12021110&dopt=Abstract
date added to LUP
2007-06-29 16:49:30
date last changed
2017-01-01 07:03:30
@article{b70deb06-52b3-4814-9a22-45a65523f17b,
  abstract     = {This article aims to estimate the prevalence of SOX13 antibodies in Swedish patients with type 1 diabetes and healthy controls. The patients (n = 102; median age 35 years [range, 9-89]) were newly diagnosed with type 1 diabetes in a defined area in southern Sweden during 1995-1998. Islet cell antibodies (ICA) were analyzed with immunofluorescence, while glutamic acid decarboxylase antibodies (GADA), tyrosine phosphatase antibodies (IA-2A), and antibodies against the transcription factor SOX13 (SOX13Ab) were analyzed with radioimmunoprecipitating assays. SOX13Ab were found in 9.8% (10/102) of type 1 patients compared to 2.0% (2/99) in healthy controls (P = 0.033). At least one of the four autoantibodies (ICA, GADA, IA-2A or SOX13Ab) were identified in 67% (68/102) of the patients. Samples positive for IA-2A were only in one case positive also for SOX13Ab. IA-2A-positive patients were often positive also for ICA and GADA (19/27), and the same combination was also common for SOX13Ab-positive patients (6/10). Only 2.0% (2/102) were positive for SOX13Ab alone. ICA, GADA and IA-2A were more frequent in younger patients (&lt;or= 35 years of age) than in older patients, while SOX13Ab showed similar frequency in both groups. We concluded that the frequency of SOX13Ab was significantly increased in Swedish patients with type 1 diabetes, but that the addition of SOX13Ab to the combination of GADA and IA2-A only increased the sensitivity by 2% for autoimmune diabetes. Therefore, SOX13 could be a minor autoantigen involved in the pathogenesis of type 1 diabetes.},
  author       = {Törn, Carina and Shtauvere-Brameus, A and Sanjeevi, C B and Landin-Olsson, Mona},
  issn         = {0077-8923},
  keyword      = {Diabetes Mellitus,Child,Autoantigens : immunology,Autoantigens : blood,Autoantibodies : immunology,Autoantibodies : blood,Aging : immunology,80 and over,Aged,Adult,Adolescence,High Mobility Group Proteins : blood,High Mobility Group Proteins : immunology,Human,Middle Age,Support,Non-U.S. Gov't,Sweden : epidemiology,Insulin-Dependent : epidemiology,Insulin-Dependent : immunology},
  language     = {eng},
  pages        = {218--223},
  publisher    = {New York Academy of Sciences},
  series       = {Annals of the New York Academy of Sciences},
  title        = {Increased autoantibodies to SOX13 in Swedish patients with type 1 diabetes.},
  url          = {http://dx.doi.org/10.1111/j.1749-6632.2002.tb02973},
  volume       = {958},
  year         = {2002},
}