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Environmental influences on functional outcome after a cortical infarct in the rat.

Risedal, Anette LU ; Mattsson, Bengt LU ; Dahlqvist, Per; Nordborg, Claes; Olsson, Tommy and Johansson, Barbro LU (2002) In Brain Research Bulletin 58(3). p.315-321
Abstract
The effect of postoperative housing conditions on functional outcome and brain-derived neurotrophic factor (BDNF) gene expression was evaluated 1 month after a distal ligation of the right middle cerebral artery (MCA) in spontaneously hypertensive rats. Two days postoperatively the rats were randomized into four groups; individually housed with no equipment (deprived group), individually housed with free access to a connected running wheel (running group), housed together in a large cage with no equipment (social group) or in the same size of cage furnished with bars, chains and various things to manipulate (enriched group). The enriched rats had significantly higher scores when crossing a rotating horizontal rod than deprived and running... (More)
The effect of postoperative housing conditions on functional outcome and brain-derived neurotrophic factor (BDNF) gene expression was evaluated 1 month after a distal ligation of the right middle cerebral artery (MCA) in spontaneously hypertensive rats. Two days postoperatively the rats were randomized into four groups; individually housed with no equipment (deprived group), individually housed with free access to a connected running wheel (running group), housed together in a large cage with no equipment (social group) or in the same size of cage furnished with bars, chains and various things to manipulate (enriched group). The enriched rats had significantly higher scores when crossing a rotating horizontal rod than deprived and running rats. The social group performed significantly better than the deprived group. The BDNF gene expression in the ipsi- and contralateral cortex, thalamus, hippocampus and cerebellum did not significantly differ between the groups. The weight of the adrenal glands was significantly increased in running rats suggesting that postischemic running may be stressful. We conclude that the beneficial effect of postischemic environmental enrichment is likely to be a combination of social and various physical activities, and that BDNF gene expression 1 month after a cortical infarct did not correlate with functional outcome. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Brain Research Bulletin
volume
58
issue
3
pages
315 - 321
publisher
Elsevier
external identifiers
  • pmid:12128159
  • wos:000177844700010
  • scopus:0035997064
ISSN
0361-9230
DOI
10.1016/S0361-9230(02)00796-7
language
English
LU publication?
yes
id
eb37d687-6298-4cd8-a078-5d8d64280807 (old id 109472)
alternative location
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12128159&dopt=Abstract
date added to LUP
2007-07-23 15:53:22
date last changed
2017-12-10 03:56:37
@article{eb37d687-6298-4cd8-a078-5d8d64280807,
  abstract     = {The effect of postoperative housing conditions on functional outcome and brain-derived neurotrophic factor (BDNF) gene expression was evaluated 1 month after a distal ligation of the right middle cerebral artery (MCA) in spontaneously hypertensive rats. Two days postoperatively the rats were randomized into four groups; individually housed with no equipment (deprived group), individually housed with free access to a connected running wheel (running group), housed together in a large cage with no equipment (social group) or in the same size of cage furnished with bars, chains and various things to manipulate (enriched group). The enriched rats had significantly higher scores when crossing a rotating horizontal rod than deprived and running rats. The social group performed significantly better than the deprived group. The BDNF gene expression in the ipsi- and contralateral cortex, thalamus, hippocampus and cerebellum did not significantly differ between the groups. The weight of the adrenal glands was significantly increased in running rats suggesting that postischemic running may be stressful. We conclude that the beneficial effect of postischemic environmental enrichment is likely to be a combination of social and various physical activities, and that BDNF gene expression 1 month after a cortical infarct did not correlate with functional outcome.},
  author       = {Risedal, Anette and Mattsson, Bengt and Dahlqvist, Per and Nordborg, Claes and Olsson, Tommy and Johansson, Barbro},
  issn         = {0361-9230},
  language     = {eng},
  number       = {3},
  pages        = {315--321},
  publisher    = {Elsevier},
  series       = {Brain Research Bulletin},
  title        = {Environmental influences on functional outcome after a cortical infarct in the rat.},
  url          = {http://dx.doi.org/10.1016/S0361-9230(02)00796-7},
  volume       = {58},
  year         = {2002},
}