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A 3-dimensional absorbed dose calculation method based on quantitative SPECT for radionuclide therapy: evaluation for (131)I using monte carlo simulation.

Ljungberg, Michael LU ; Sjögreen Gleisner, Katarina LU ; Liu, Xiaowei; Frey, Eric; Dewaraja, Yuni and Strand, Sven-Erik LU (2002) In Journal of Nuclear Medicine 43(8). p.1101-1109
Abstract
A general method is presented for patient-specific 3-dimensional absorbed dose calculations based on quantitative SPECT activity measurements. METHODS: The computational scheme includes a method for registration of the CT image to the SPECT image and position-dependent compensation for attenuation, scatter, and collimator detector response performed as part of an iterative reconstruction method. A method for conversion of the measured activity distribution to a 3-dimensional absorbed dose distribution, based on the EGS4 (electron-gamma shower, version 4) Monte Carlo code, is also included. The accuracy of the activity quantification and the absorbed dose calculation is evaluated on the basis of realistic Monte Carlo-simulated SPECT data,... (More)
A general method is presented for patient-specific 3-dimensional absorbed dose calculations based on quantitative SPECT activity measurements. METHODS: The computational scheme includes a method for registration of the CT image to the SPECT image and position-dependent compensation for attenuation, scatter, and collimator detector response performed as part of an iterative reconstruction method. A method for conversion of the measured activity distribution to a 3-dimensional absorbed dose distribution, based on the EGS4 (electron-gamma shower, version 4) Monte Carlo code, is also included. The accuracy of the activity quantification and the absorbed dose calculation is evaluated on the basis of realistic Monte Carlo-simulated SPECT data, using the SIMIND (simulation of imaging nuclear detectors) program and a voxel-based computer phantom. CT images are obtained from the computer phantom, and realistic patient movements are added relative to the SPECT image. The SPECT-based activity concentration and absorbed dose distributions are compared with the true ones. RESULTS: Correction could be made for object scatter, photon attenuation, and scatter penetration in the collimator. However, inaccuracies were imposed by the limited spatial resolution of the SPECT system, for which the collimator response correction did not fully compensate. CONCLUSION: The presented method includes compensation for most parameters degrading the quantitative image information. The compensation methods are based on physical models and therefore are generally applicable to other radionuclides. The proposed evaluation methodology may be used as a basis for future intercomparison of different methods. (Less)
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published
subject
keywords
Non-U.S. Gov't, Radiotherapy Dosage, Imaging, Phantoms, Monte Carlo Method, Iodine Radioisotopes : therapeutic use, Computer-Assisted, Image Processing, Human, Support, Single-Photon, P.H.S., U.S. Gov't, Tomography, Emission-Computed
in
Journal of Nuclear Medicine
volume
43
issue
8
pages
1101 - 1109
publisher
Society of Nuclear Medicine
external identifiers
  • wos:000177352100023
ISSN
0161-5505
language
English
LU publication?
yes
id
81e5d00e-fff3-47be-aaec-af2032da00f7 (old id 109747)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12163637&dopt=Abstract
date added to LUP
2007-07-20 08:20:16
date last changed
2016-04-16 05:26:39
@article{81e5d00e-fff3-47be-aaec-af2032da00f7,
  abstract     = {A general method is presented for patient-specific 3-dimensional absorbed dose calculations based on quantitative SPECT activity measurements. METHODS: The computational scheme includes a method for registration of the CT image to the SPECT image and position-dependent compensation for attenuation, scatter, and collimator detector response performed as part of an iterative reconstruction method. A method for conversion of the measured activity distribution to a 3-dimensional absorbed dose distribution, based on the EGS4 (electron-gamma shower, version 4) Monte Carlo code, is also included. The accuracy of the activity quantification and the absorbed dose calculation is evaluated on the basis of realistic Monte Carlo-simulated SPECT data, using the SIMIND (simulation of imaging nuclear detectors) program and a voxel-based computer phantom. CT images are obtained from the computer phantom, and realistic patient movements are added relative to the SPECT image. The SPECT-based activity concentration and absorbed dose distributions are compared with the true ones. RESULTS: Correction could be made for object scatter, photon attenuation, and scatter penetration in the collimator. However, inaccuracies were imposed by the limited spatial resolution of the SPECT system, for which the collimator response correction did not fully compensate. CONCLUSION: The presented method includes compensation for most parameters degrading the quantitative image information. The compensation methods are based on physical models and therefore are generally applicable to other radionuclides. The proposed evaluation methodology may be used as a basis for future intercomparison of different methods.},
  author       = {Ljungberg, Michael and Sjögreen Gleisner, Katarina and Liu, Xiaowei and Frey, Eric and Dewaraja, Yuni and Strand, Sven-Erik},
  issn         = {0161-5505},
  keyword      = {Non-U.S. Gov't,Radiotherapy Dosage,Imaging,Phantoms,Monte Carlo Method,Iodine Radioisotopes : therapeutic use,Computer-Assisted,Image Processing,Human,Support,Single-Photon,P.H.S.,U.S. Gov't,Tomography,Emission-Computed},
  language     = {eng},
  number       = {8},
  pages        = {1101--1109},
  publisher    = {Society of Nuclear Medicine},
  series       = {Journal of Nuclear Medicine},
  title        = {A 3-dimensional absorbed dose calculation method based on quantitative SPECT for radionuclide therapy: evaluation for (131)I using monte carlo simulation.},
  volume       = {43},
  year         = {2002},
}