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Transplantation of reprogrammed neurons for improved recovery after stroke

Kokaia, Z. LU ; Tornero, D. LU and Lindvall, O. LU (2017) In Progress in Brain Research
Abstract

Somatic cells such as fibroblasts, reprogrammed to induced pluripotent stem cells, can be used to generate neural stem/progenitor cells or neuroblasts for transplantation. In this review, we summarize recent studies demonstrating that when grafted intracerebrally in animal models of stroke, reprogrammed neurons improve function, probably by several different mechanisms, e.g., trophic actions, modulation of inflammation, promotion of angiogenesis, cellular and synaptic plasticity, and neuroprotection. In our own work, we have shown that human skin-derived reprogrammed neurons, fated to cortical progeny, integrate in stroke-injured neuronal network and form functional afferent synapses with host neurons, responding to peripheral sensory... (More)

Somatic cells such as fibroblasts, reprogrammed to induced pluripotent stem cells, can be used to generate neural stem/progenitor cells or neuroblasts for transplantation. In this review, we summarize recent studies demonstrating that when grafted intracerebrally in animal models of stroke, reprogrammed neurons improve function, probably by several different mechanisms, e.g., trophic actions, modulation of inflammation, promotion of angiogenesis, cellular and synaptic plasticity, and neuroprotection. In our own work, we have shown that human skin-derived reprogrammed neurons, fated to cortical progeny, integrate in stroke-injured neuronal network and form functional afferent synapses with host neurons, responding to peripheral sensory stimulation. However, whether neuronal replacement plays a role for the improvement of sensory, motor, and cognitive deficits after transplantation of reprogrammed neurons is still unclear. We conclude that further preclinical studies are needed to understand the therapeutic potential of grafted reprogrammed neurons and to define a road map for their clinical translation in stroke.

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author
organization
publishing date
type
Contribution to journal
publication status
epub
subject
keywords
Brain repair, Fibroblasts, Functional recovery, Regeneration, Reprogramming, Stroke
in
Progress in Brain Research
publisher
Elsevier
external identifiers
  • scopus:85008680938
ISSN
0079-6123
DOI
10.1016/bs.pbr.2016.11.013
language
English
LU publication?
yes
id
10d0ff1e-068f-4516-b743-f02adb0d930d
date added to LUP
2017-03-16 14:44:02
date last changed
2017-06-16 03:00:17
@article{10d0ff1e-068f-4516-b743-f02adb0d930d,
  abstract     = {<p>Somatic cells such as fibroblasts, reprogrammed to induced pluripotent stem cells, can be used to generate neural stem/progenitor cells or neuroblasts for transplantation. In this review, we summarize recent studies demonstrating that when grafted intracerebrally in animal models of stroke, reprogrammed neurons improve function, probably by several different mechanisms, e.g., trophic actions, modulation of inflammation, promotion of angiogenesis, cellular and synaptic plasticity, and neuroprotection. In our own work, we have shown that human skin-derived reprogrammed neurons, fated to cortical progeny, integrate in stroke-injured neuronal network and form functional afferent synapses with host neurons, responding to peripheral sensory stimulation. However, whether neuronal replacement plays a role for the improvement of sensory, motor, and cognitive deficits after transplantation of reprogrammed neurons is still unclear. We conclude that further preclinical studies are needed to understand the therapeutic potential of grafted reprogrammed neurons and to define a road map for their clinical translation in stroke.</p>},
  author       = {Kokaia, Z. and Tornero, D. and Lindvall, O.},
  issn         = {0079-6123},
  keyword      = {Brain repair,Fibroblasts,Functional recovery,Regeneration,Reprogramming,Stroke},
  language     = {eng},
  month        = {01},
  publisher    = {Elsevier},
  series       = {Progress in Brain Research},
  title        = {Transplantation of reprogrammed neurons for improved recovery after stroke},
  url          = {http://dx.doi.org/10.1016/bs.pbr.2016.11.013},
  year         = {2017},
}