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The association between leptin and proinsulin is lost with central obesity.

Söderberg, S; Ahrén, Bo LU ; Eliasson, M; Dinesen, B and Olsson, T (2002) In Journal of Internal Medicine1989-01-01+01:00 252(2). p.140-148
Abstract
Abstract. Söderberg S, Ahrén B, Eliasson M, DinesenB, Olsson T (Umeå University, Umeå, Lund University and Luleå Hospital, Lund, Sweden; and Steno Diabetes Center, Gentofte, Denmark). The association between leptin and proinsulin is lost with central obesity. J Intern Med 2002; 252: 140-148. OBJECTIVE: Hyperproinsulinaemia and hyperleptinaemia are interrelated features of the insulin resistance syndrome that are linked to the prospective risk of cardiovascular diseases. Whether the association between leptin and proinsulin is different between groups displaying different degrees of risk for cardiovascular diseases is not known. We therefore examined this association in men versus women and in pre- versus postmenopausal women from a... (More)
Abstract. Söderberg S, Ahrén B, Eliasson M, DinesenB, Olsson T (Umeå University, Umeå, Lund University and Luleå Hospital, Lund, Sweden; and Steno Diabetes Center, Gentofte, Denmark). The association between leptin and proinsulin is lost with central obesity. J Intern Med 2002; 252: 140-148. OBJECTIVE: Hyperproinsulinaemia and hyperleptinaemia are interrelated features of the insulin resistance syndrome that are linked to the prospective risk of cardiovascular diseases. Whether the association between leptin and proinsulin is different between groups displaying different degrees of risk for cardiovascular diseases is not known. We therefore examined this association in men versus women and in pre- versus postmenopausal women from a population-based sample. DESIGN AND SUBJECTS: Healthy subjects (n = 158; 85 men and 73 pre- and postmenopausal women) from the Northern Sweden Monitoring of Trends and Determinants in Cardiovascular Disease population were studied with a cross-sectional design. METHODS: Anthropometric measurements (body mass index and waist circumference) and oral glucose tolerance tests were performed. Enzyme-linked immunosorbent assays were used for the analyses of specific insulin and proinsulin, and radioimmunoassay for leptin. Insulin resistance and beta-cell function were calculated according to the homeostasis assessment model. Partial correlation coefficients adjusted for age and measures of adiposity were calculated and multiple linear regression analyses were performed with leptin as dependent variable. RESULTS: In nonobese men and premenopausal women and in obese postmenopausal women, leptin was significantly associated with proinsulin after stratification for waist circumference. Furthermore, a multivariate analyses taking age and measures of adiposity into account, showed that high fasting proinsulin was a significant predictor of high leptin in these groups. In contrast, this association was lost with increasing central obesity in men and premenopausal women. CONCLUSIONS: This study shows that both the degree of adiposity and the hormonal milieu influence the association between circulating leptin and proinsulin in a normal population. Therefore, the insulin resistance syndrome seems to be characterized by lost association between leptin and proinsulin, which may be explained by dysfunction in the adipoinsular axis. (Less)
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type
Contribution to journal
publication status
published
subject
in
Journal of Internal Medicine1989-01-01+01:00
volume
252
issue
2
pages
140 - 148
publisher
Wiley-Blackwell Publishing Ltd
external identifiers
  • wos:000177545500006
  • pmid:12190889
  • scopus:0036371722
ISSN
1365-2796
DOI
10.1046/j.1365-2796.2002.01018.x
language
English
LU publication?
yes
id
d963857a-aa07-4640-8321-48762aa0dc17 (old id 110030)
alternative location
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12190889&dopt=Abstract
date added to LUP
2007-06-29 16:03:47
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2017-01-01 06:38:26
@article{d963857a-aa07-4640-8321-48762aa0dc17,
  abstract     = {Abstract. Söderberg S, Ahrén B, Eliasson M, DinesenB, Olsson T (Umeå University, Umeå, Lund University and Luleå Hospital, Lund, Sweden; and Steno Diabetes Center, Gentofte, Denmark). The association between leptin and proinsulin is lost with central obesity. J Intern Med 2002; 252: 140-148. OBJECTIVE: Hyperproinsulinaemia and hyperleptinaemia are interrelated features of the insulin resistance syndrome that are linked to the prospective risk of cardiovascular diseases. Whether the association between leptin and proinsulin is different between groups displaying different degrees of risk for cardiovascular diseases is not known. We therefore examined this association in men versus women and in pre- versus postmenopausal women from a population-based sample. DESIGN AND SUBJECTS: Healthy subjects (n = 158; 85 men and 73 pre- and postmenopausal women) from the Northern Sweden Monitoring of Trends and Determinants in Cardiovascular Disease population were studied with a cross-sectional design. METHODS: Anthropometric measurements (body mass index and waist circumference) and oral glucose tolerance tests were performed. Enzyme-linked immunosorbent assays were used for the analyses of specific insulin and proinsulin, and radioimmunoassay for leptin. Insulin resistance and beta-cell function were calculated according to the homeostasis assessment model. Partial correlation coefficients adjusted for age and measures of adiposity were calculated and multiple linear regression analyses were performed with leptin as dependent variable. RESULTS: In nonobese men and premenopausal women and in obese postmenopausal women, leptin was significantly associated with proinsulin after stratification for waist circumference. Furthermore, a multivariate analyses taking age and measures of adiposity into account, showed that high fasting proinsulin was a significant predictor of high leptin in these groups. In contrast, this association was lost with increasing central obesity in men and premenopausal women. CONCLUSIONS: This study shows that both the degree of adiposity and the hormonal milieu influence the association between circulating leptin and proinsulin in a normal population. Therefore, the insulin resistance syndrome seems to be characterized by lost association between leptin and proinsulin, which may be explained by dysfunction in the adipoinsular axis.},
  author       = {Söderberg, S and Ahrén, Bo and Eliasson, M and Dinesen, B and Olsson, T},
  issn         = {1365-2796},
  language     = {eng},
  number       = {2},
  pages        = {140--148},
  publisher    = {Wiley-Blackwell Publishing Ltd},
  series       = {Journal of Internal Medicine1989-01-01+01:00},
  title        = {The association between leptin and proinsulin is lost with central obesity.},
  url          = {http://dx.doi.org/10.1046/j.1365-2796.2002.01018.x},
  volume       = {252},
  year         = {2002},
}