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Role of maternal smoking and maternal reproductive history in the etiology of hypospadias in the offspring.

Källén, Karin LU (2002) In Teratology1968-01-01+01:002003-01-01+01:00 66(4). p.185-191
Abstract
BACKGROUND: This study was undertaken to evaluate some possible risk factors for hypospadias with special regard to parity, subfertility and maternal smoking. METHODS: With the use of the Swedish health registries, 3,262 infants with a diagnosis of hypospadias were identified among 1,413,811 infants born in 1983-96 with prospectively collected smoking exposure during pregnancy. Odds ratios (OR) and 95% confidence intervals (CI) were calculated after adjustment for various possible confounders. RESULTS: A negative association between hypospadias and maternal smoking was found (OR: 0.83 95% CI: 0.76-0.90), but this association was only observed among mothers of Parity 1 or 4+, and the possibility of the results being due to confounding was... (More)
BACKGROUND: This study was undertaken to evaluate some possible risk factors for hypospadias with special regard to parity, subfertility and maternal smoking. METHODS: With the use of the Swedish health registries, 3,262 infants with a diagnosis of hypospadias were identified among 1,413,811 infants born in 1983-96 with prospectively collected smoking exposure during pregnancy. Odds ratios (OR) and 95% confidence intervals (CI) were calculated after adjustment for various possible confounders. RESULTS: A negative association between hypospadias and maternal smoking was found (OR: 0.83 95% CI: 0.76-0.90), but this association was only observed among mothers of Parity 1 or 4+, and the possibility of the results being due to confounding was suspected. Primiparity (vs. Parity 2) was positively associated with hypospadias (OR: 1.29 95% CI: 1.19-1.40), and so was subfertility (defined here as at least 1 year of attempts to conceive) (OR for subfertility: 1.16 95% CI: 1.01-1.33). The OR for smoking and primiparity, respectively, were of the same magnitude irrespective of whether subfertility was present or not, and no evidence was found that subfertility in the parents of infants with hypospadias seriously confounded the analyses. CONCLUSIONS: No explanation was found for the negative association between maternal smoking and hypospadias or the positive association between primiparity and hypospadias. Possible causal mechanisms are discussed. Teratology 66:185-191, 2002. (Less)
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organization
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Contribution to journal
publication status
published
subject
in
Teratology1968-01-01+01:002003-01-01+01:00
volume
66
issue
4
pages
185 - 191
publisher
John Wiley & Sons
external identifiers
  • wos:000178375100007
  • pmid:12353215
  • scopus:0036388885
ISSN
1096-9926
DOI
10.1002/tera.10092
language
English
LU publication?
yes
id
4bfcd624-0069-45c2-80c4-3c93ee751235 (old id 110141)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12353215&dopt=Abstract
date added to LUP
2007-07-06 09:49:49
date last changed
2017-11-30 09:38:09
@article{4bfcd624-0069-45c2-80c4-3c93ee751235,
  abstract     = {BACKGROUND: This study was undertaken to evaluate some possible risk factors for hypospadias with special regard to parity, subfertility and maternal smoking. METHODS: With the use of the Swedish health registries, 3,262 infants with a diagnosis of hypospadias were identified among 1,413,811 infants born in 1983-96 with prospectively collected smoking exposure during pregnancy. Odds ratios (OR) and 95% confidence intervals (CI) were calculated after adjustment for various possible confounders. RESULTS: A negative association between hypospadias and maternal smoking was found (OR: 0.83 95% CI: 0.76-0.90), but this association was only observed among mothers of Parity 1 or 4+, and the possibility of the results being due to confounding was suspected. Primiparity (vs. Parity 2) was positively associated with hypospadias (OR: 1.29 95% CI: 1.19-1.40), and so was subfertility (defined here as at least 1 year of attempts to conceive) (OR for subfertility: 1.16 95% CI: 1.01-1.33). The OR for smoking and primiparity, respectively, were of the same magnitude irrespective of whether subfertility was present or not, and no evidence was found that subfertility in the parents of infants with hypospadias seriously confounded the analyses. CONCLUSIONS: No explanation was found for the negative association between maternal smoking and hypospadias or the positive association between primiparity and hypospadias. Possible causal mechanisms are discussed. Teratology 66:185-191, 2002.},
  author       = {Källén, Karin},
  issn         = {1096-9926},
  language     = {eng},
  number       = {4},
  pages        = {185--191},
  publisher    = {John Wiley & Sons},
  series       = {Teratology1968-01-01+01:002003-01-01+01:00},
  title        = {Role of maternal smoking and maternal reproductive history in the etiology of hypospadias in the offspring.},
  url          = {http://dx.doi.org/10.1002/tera.10092},
  volume       = {66},
  year         = {2002},
}