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Immunohistochemical localization and vascular effects of vasoactive intestinal polypeptide in skeletal muscle of the cat

Järhult, Johannes; Hellstrand, Per LU and Sundler, Frank LU (1980) In Cell and Tissue Research 207(1). p.55-64
Abstract
Scattered vasoactive intestinal polypeptide (VIP)-immunoreactive nerves were found in the striated muscle of the hind limb of the cat, where they usually were associated with small blood vessels. VIP-immunoreactive nerves were also demonstrated in the sciatic nerve; after ligation an abundance of intensely immunoreactive VIP fibres were seen proximal to the ligation. Intraarterial infusion of VIP into isolated hind limb of the cat had dramatic effects on different sections of the vascular bed. Thus, VIP dilated the resistance vessels leading to a marked increment in muscle blood flow. VIP also relaxed the capacitance vessels causing regional pooling of blood; it increased the capillary surface area available for fluid exchange. Infusions... (More)
Scattered vasoactive intestinal polypeptide (VIP)-immunoreactive nerves were found in the striated muscle of the hind limb of the cat, where they usually were associated with small blood vessels. VIP-immunoreactive nerves were also demonstrated in the sciatic nerve; after ligation an abundance of intensely immunoreactive VIP fibres were seen proximal to the ligation. Intraarterial infusion of VIP into isolated hind limb of the cat had dramatic effects on different sections of the vascular bed. Thus, VIP dilated the resistance vessels leading to a marked increment in muscle blood flow. VIP also relaxed the capacitance vessels causing regional pooling of blood; it increased the capillary surface area available for fluid exchange. Infusions of VIP at a dose of 8 microgram/min significantly inhibited the vasoconstriction, induced by electrical stimulation of the regional sympathetic nerves. It is suggested that local nervous release of VIP may act as a modulator of vascular tone in skeletal muscle. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Skeletal muscle (cat), Vasoactive intestinal polypeptide (VIP), Peptidergic nerves, Vascular effects
in
Cell and Tissue Research
volume
207
issue
1
pages
55 - 64
publisher
Springer
external identifiers
  • pmid:7388912
  • scopus:0018852314
ISSN
1432-0878
DOI
10.1007/BF00239329
language
English
LU publication?
yes
id
c79ef6ba-2642-4195-87fc-4e3367f14b1b (old id 1102788)
date added to LUP
2008-08-14 09:22:32
date last changed
2017-08-06 03:41:20
@article{c79ef6ba-2642-4195-87fc-4e3367f14b1b,
  abstract     = {Scattered vasoactive intestinal polypeptide (VIP)-immunoreactive nerves were found in the striated muscle of the hind limb of the cat, where they usually were associated with small blood vessels. VIP-immunoreactive nerves were also demonstrated in the sciatic nerve; after ligation an abundance of intensely immunoreactive VIP fibres were seen proximal to the ligation. Intraarterial infusion of VIP into isolated hind limb of the cat had dramatic effects on different sections of the vascular bed. Thus, VIP dilated the resistance vessels leading to a marked increment in muscle blood flow. VIP also relaxed the capacitance vessels causing regional pooling of blood; it increased the capillary surface area available for fluid exchange. Infusions of VIP at a dose of 8 microgram/min significantly inhibited the vasoconstriction, induced by electrical stimulation of the regional sympathetic nerves. It is suggested that local nervous release of VIP may act as a modulator of vascular tone in skeletal muscle.},
  author       = {Järhult, Johannes and Hellstrand, Per and Sundler, Frank},
  issn         = {1432-0878},
  keyword      = {Skeletal muscle (cat),Vasoactive intestinal polypeptide (VIP),Peptidergic nerves,Vascular effects},
  language     = {eng},
  number       = {1},
  pages        = {55--64},
  publisher    = {Springer},
  series       = {Cell and Tissue Research},
  title        = {Immunohistochemical localization and vascular effects of vasoactive intestinal polypeptide in skeletal muscle of the cat},
  url          = {http://dx.doi.org/10.1007/BF00239329},
  volume       = {207},
  year         = {1980},
}