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Determination of wound strength for quantitation of skin damage after pressure ischemia. An experimental study in rabbits

Lauritzen, Claes; Bagge, Ulf and Bjursten, Lars Magnus LU (1981) In Scandinavian Journal of Plastic and Reconstructive Surgery 15(2). p.93-95
Abstract
Rabbits skin folds were placed in plexiglass chambers enabling control of the skin fold temperature during cuff compression (200 mmHg) for 4 hours. In 10 animals the skin folds were kept at 36 degrees C - in another 10 animals the skin fold temperature was lowered to 10 degrees C. To quantitate the skin injury caused by the pressure ischemia a standardized wound was made, and immediately closed, after release of pressure. Control wounds were made in normal skin. Seven days later the mechanical strength of the wounds was tested by determination of breaking load. There was no significant difference in breaking load between the wounds made in normal skin and in the skin folds kept at 10 degrees C, whereas the breaking loads was significantly... (More)
Rabbits skin folds were placed in plexiglass chambers enabling control of the skin fold temperature during cuff compression (200 mmHg) for 4 hours. In 10 animals the skin folds were kept at 36 degrees C - in another 10 animals the skin fold temperature was lowered to 10 degrees C. To quantitate the skin injury caused by the pressure ischemia a standardized wound was made, and immediately closed, after release of pressure. Control wounds were made in normal skin. Seven days later the mechanical strength of the wounds was tested by determination of breaking load. There was no significant difference in breaking load between the wounds made in normal skin and in the skin folds kept at 10 degrees C, whereas the breaking loads was significantly decreased in the wounds made in skin folds kept at 36 degrees C, i.e. normal skin temperature, compared with the controls. Thus, the results show that cooling may preserve the reparative capacity in skin subjected to pressure ischemia. It is assumed that this effect is related to a lowered cell metabolism during the ischemia. It may also be concluded that the pressure (mechanical) injury, being the same in both temperature groups, is less important than the ischemic injury. (Less)
Please use this url to cite or link to this publication:
author
publishing date
type
Contribution to journal
publication status
published
subject
in
Scandinavian Journal of Plastic and Reconstructive Surgery
volume
15
issue
2
pages
93 - 95
publisher
Scandinavian University Press
external identifiers
  • pmid:7339878
  • scopus:0019512274
ISSN
0036-5556
DOI
10.3109/02844318109103420
language
English
LU publication?
no
id
7be64a19-fc14-4aff-95bd-cba11b675320 (old id 1102810)
date added to LUP
2008-08-13 15:24:18
date last changed
2017-01-01 06:59:30
@article{7be64a19-fc14-4aff-95bd-cba11b675320,
  abstract     = {Rabbits skin folds were placed in plexiglass chambers enabling control of the skin fold temperature during cuff compression (200 mmHg) for 4 hours. In 10 animals the skin folds were kept at 36 degrees C - in another 10 animals the skin fold temperature was lowered to 10 degrees C. To quantitate the skin injury caused by the pressure ischemia a standardized wound was made, and immediately closed, after release of pressure. Control wounds were made in normal skin. Seven days later the mechanical strength of the wounds was tested by determination of breaking load. There was no significant difference in breaking load between the wounds made in normal skin and in the skin folds kept at 10 degrees C, whereas the breaking loads was significantly decreased in the wounds made in skin folds kept at 36 degrees C, i.e. normal skin temperature, compared with the controls. Thus, the results show that cooling may preserve the reparative capacity in skin subjected to pressure ischemia. It is assumed that this effect is related to a lowered cell metabolism during the ischemia. It may also be concluded that the pressure (mechanical) injury, being the same in both temperature groups, is less important than the ischemic injury.},
  author       = {Lauritzen, Claes and Bagge, Ulf and Bjursten, Lars Magnus},
  issn         = {0036-5556},
  language     = {eng},
  number       = {2},
  pages        = {93--95},
  publisher    = {Scandinavian University Press},
  series       = {Scandinavian Journal of Plastic and Reconstructive Surgery},
  title        = {Determination of wound strength for quantitation of skin damage after pressure ischemia. An experimental study in rabbits},
  url          = {http://dx.doi.org/10.3109/02844318109103420},
  volume       = {15},
  year         = {1981},
}