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Energy turnover and mechanical properties of resting and contracting aortas and portal veins from normotensive and spontaneously hypertensive rats

Arner, Anders LU and Hellstrand, Per LU (1981) In Circulation Research 48(4). p.539-548
Abstract
Aortas and portal veins from spontaneously hypertensive rats (SHR) and matched normotensive Wistar-Kyoto rats (WKY) were studied with respect to their energy turnover and mechanical properties. Relaxed aortas fom SHR 16--17 weeks and 20--25 weeks of age were stiffer, had smaller circumference, and greater maximal active wall tension compared to WKY aortas. Active stress (forced/areas) was not different. Passive and active length-force relations of portal veins from 16 to 17-week-old SHR and WKY were not different. O2 consumption (JO2) and lactate production (JLA) were studied in aortas and portal veins from 20- to 25-week-old rats. In relaxed aortas, JO2 was 0.63 +/- 0.03 (n = 1) and 0.54 +/- 0.03 (n = 10) mu mol/min per g dry wt in SHR... (More)
Aortas and portal veins from spontaneously hypertensive rats (SHR) and matched normotensive Wistar-Kyoto rats (WKY) were studied with respect to their energy turnover and mechanical properties. Relaxed aortas fom SHR 16--17 weeks and 20--25 weeks of age were stiffer, had smaller circumference, and greater maximal active wall tension compared to WKY aortas. Active stress (forced/areas) was not different. Passive and active length-force relations of portal veins from 16 to 17-week-old SHR and WKY were not different. O2 consumption (JO2) and lactate production (JLA) were studied in aortas and portal veins from 20- to 25-week-old rats. In relaxed aortas, JO2 was 0.63 +/- 0.03 (n = 1) and 0.54 +/- 0.03 (n = 10) mu mol/min per g dry wt in SHR and WKY, respectively (P less than 0.05). On activation by high-K+ solution, JO2 increased with tension in a similar way in both groups. In contrast, JLA, about 0.85 mu mol/min per g, did not differ, and decreased with tension development. JO2 of relaxed portal veins, about 1.5 mu mol/min per g dry wt, and the increase in JO2 with contraction were not different between SHR and WKY, but the JO2-active stress relation was steeper in spontaneous activity than in Kv+ contractures. JLA was similar in SHR and WKY portal veins, about 1 mu mol/min per g, and unlike behavior of the aortas, it increased with tension. Thus it is evident that SHR show increased arterial metabolism, which is not accounted for by an increased energy demand of the contractile system. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Circulation Research
volume
48
issue
4
pages
539 - 548
publisher
American Heart Association
external identifiers
  • pmid:7460223
  • scopus:0019497862
ISSN
0009-7330
language
English
LU publication?
yes
id
0e8e84ed-4a9c-4900-a4e4-7ada185377d0 (old id 1102885)
alternative location
http://circres.ahajournals.org/cgi/reprint/48/4/539
date added to LUP
2008-08-13 16:20:37
date last changed
2017-01-15 04:09:27
@article{0e8e84ed-4a9c-4900-a4e4-7ada185377d0,
  abstract     = {Aortas and portal veins from spontaneously hypertensive rats (SHR) and matched normotensive Wistar-Kyoto rats (WKY) were studied with respect to their energy turnover and mechanical properties. Relaxed aortas fom SHR 16--17 weeks and 20--25 weeks of age were stiffer, had smaller circumference, and greater maximal active wall tension compared to WKY aortas. Active stress (forced/areas) was not different. Passive and active length-force relations of portal veins from 16 to 17-week-old SHR and WKY were not different. O2 consumption (JO2) and lactate production (JLA) were studied in aortas and portal veins from 20- to 25-week-old rats. In relaxed aortas, JO2 was 0.63 +/- 0.03 (n = 1) and 0.54 +/- 0.03 (n = 10) mu mol/min per g dry wt in SHR and WKY, respectively (P less than 0.05). On activation by high-K+ solution, JO2 increased with tension in a similar way in both groups. In contrast, JLA, about 0.85 mu mol/min per g, did not differ, and decreased with tension development. JO2 of relaxed portal veins, about 1.5 mu mol/min per g dry wt, and the increase in JO2 with contraction were not different between SHR and WKY, but the JO2-active stress relation was steeper in spontaneous activity than in Kv+ contractures. JLA was similar in SHR and WKY portal veins, about 1 mu mol/min per g, and unlike behavior of the aortas, it increased with tension. Thus it is evident that SHR show increased arterial metabolism, which is not accounted for by an increased energy demand of the contractile system.},
  author       = {Arner, Anders and Hellstrand, Per},
  issn         = {0009-7330},
  language     = {eng},
  number       = {4},
  pages        = {539--548},
  publisher    = {American Heart Association},
  series       = {Circulation Research},
  title        = {Energy turnover and mechanical properties of resting and contracting aortas and portal veins from normotensive and spontaneously hypertensive rats},
  volume       = {48},
  year         = {1981},
}