Advanced

Inhibitory effect of honey bee venom on immune complex mediated leukocyte migration into rabbit knee-joints

Thomsen, P; Bjursten, Lars Magnus LU ; Ahlstedt, S; Bagge, U and Bjorksten, B (1984) In Agents and Actions 14(5-6). p.662-666
Abstract
The anti-inflammatory effect of purified honey bee venom (HBV) was studied using a recently described animal model in which preformed immune complexes were injected into rabbit knee-joints. As little as a single injection of 1.2 micrograms HBV/kg body weight subcutaneously significantly reduced the immune complex induced joint inflammation as measured by reduction in leukocyte counts in the joint fluid. This decrease was obvious 3 and 6 but not 9 hours after induction of the inflammation. There was no significant effect on leukocyte random migration, chemotactic responsiveness or phagocytosis, indicating that HBV did not interfere with normal phagocyte motility and ingestion. The modifying effects by HBV on the inflammatory response to... (More)
The anti-inflammatory effect of purified honey bee venom (HBV) was studied using a recently described animal model in which preformed immune complexes were injected into rabbit knee-joints. As little as a single injection of 1.2 micrograms HBV/kg body weight subcutaneously significantly reduced the immune complex induced joint inflammation as measured by reduction in leukocyte counts in the joint fluid. This decrease was obvious 3 and 6 but not 9 hours after induction of the inflammation. There was no significant effect on leukocyte random migration, chemotactic responsiveness or phagocytosis, indicating that HBV did not interfere with normal phagocyte motility and ingestion. The modifying effects by HBV on the inflammatory response to immune complexes in vivo is most likely due to interference with other components of the inflammatory response. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Agents and Actions
volume
14
issue
5-6
pages
662 - 666
publisher
Springer
external identifiers
  • pmid:6475661
  • scopus:0021443282
ISSN
0065-4299
DOI
10.1007/BF01978904
language
English
LU publication?
yes
id
ca331856-029a-435b-bd0e-061fffcc9024 (old id 1103162)
date added to LUP
2008-08-12 13:39:45
date last changed
2017-01-01 06:53:21
@article{ca331856-029a-435b-bd0e-061fffcc9024,
  abstract     = {The anti-inflammatory effect of purified honey bee venom (HBV) was studied using a recently described animal model in which preformed immune complexes were injected into rabbit knee-joints. As little as a single injection of 1.2 micrograms HBV/kg body weight subcutaneously significantly reduced the immune complex induced joint inflammation as measured by reduction in leukocyte counts in the joint fluid. This decrease was obvious 3 and 6 but not 9 hours after induction of the inflammation. There was no significant effect on leukocyte random migration, chemotactic responsiveness or phagocytosis, indicating that HBV did not interfere with normal phagocyte motility and ingestion. The modifying effects by HBV on the inflammatory response to immune complexes in vivo is most likely due to interference with other components of the inflammatory response.},
  author       = {Thomsen, P and Bjursten, Lars Magnus and Ahlstedt, S and Bagge, U and Bjorksten, B},
  issn         = {0065-4299},
  language     = {eng},
  number       = {5-6},
  pages        = {662--666},
  publisher    = {Springer},
  series       = {Agents and Actions},
  title        = {Inhibitory effect of honey bee venom on immune complex mediated leukocyte migration into rabbit knee-joints},
  url          = {http://dx.doi.org/10.1007/BF01978904},
  volume       = {14},
  year         = {1984},
}