Advanced

Blood group specific oligosaccharides from faeces of a blood group A breast-fed infant

Sabharwal, H; Nilsson, B; Chester, Alan LU ; Sjöblad, Sture LU and Lundblad, A (1984) In Molecular Immunology 21(11). p.1105-1112
Abstract
Four different oligosaccharides were isolated from faeces collected from a blood group A, secretor, breast-fed infant. Three of these, GalNAc alpha 1-3[Fuc alpha 1-2]Gal beta 1-4Glc (A-tetrasaccharide), GalNAc alpha 1-3[Fuc alpha 1-2]Gal beta 1-4[Fuc alpha 1-3]Glc (A-pentasaccharide) and 1-3[Fuc alpha 1-4]GlcNAc beta 1-3Gal beta 1-4Glc (A-heptasaccharide) have previously found in urine, whereas GalNAc alpha 1-3[Fuc alpha 1-2]Gal beta 1-3GlcNAc beta 1-3Gal beta 1-4Glc (A-hexasaccharide) is a new compound. Structures were deduced by mass spectrometry of permethylated and N-trifluoroacetylated oligosaccharide alditols. The latter gave more structural information than the corresponding N-acetyl derivatives. The four oligosaccharides were... (More)
Four different oligosaccharides were isolated from faeces collected from a blood group A, secretor, breast-fed infant. Three of these, GalNAc alpha 1-3[Fuc alpha 1-2]Gal beta 1-4Glc (A-tetrasaccharide), GalNAc alpha 1-3[Fuc alpha 1-2]Gal beta 1-4[Fuc alpha 1-3]Glc (A-pentasaccharide) and 1-3[Fuc alpha 1-4]GlcNAc beta 1-3Gal beta 1-4Glc (A-heptasaccharide) have previously found in urine, whereas GalNAc alpha 1-3[Fuc alpha 1-2]Gal beta 1-3GlcNAc beta 1-3Gal beta 1-4Glc (A-hexasaccharide) is a new compound. Structures were deduced by mass spectrometry of permethylated and N-trifluoroacetylated oligosaccharide alditols. The latter gave more structural information than the corresponding N-acetyl derivatives. The four oligosaccharides were tested for blood group A activity and all were found to inhibit the binding of anti-A antibody to blood group A substance. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Molecular Immunology
volume
21
issue
11
pages
1105 - 1112
publisher
Pergamon
external identifiers
  • pmid:6513935
  • scopus:0021680739
ISSN
1872-9142
DOI
10.1016/0161-5890(84)90121-4
language
English
LU publication?
yes
id
bf0ad4ed-13eb-4b0a-8e14-420ef1b0274a (old id 1103202)
date added to LUP
2008-08-12 14:22:57
date last changed
2017-07-23 04:40:29
@article{bf0ad4ed-13eb-4b0a-8e14-420ef1b0274a,
  abstract     = {Four different oligosaccharides were isolated from faeces collected from a blood group A, secretor, breast-fed infant. Three of these, GalNAc alpha 1-3[Fuc alpha 1-2]Gal beta 1-4Glc (A-tetrasaccharide), GalNAc alpha 1-3[Fuc alpha 1-2]Gal beta 1-4[Fuc alpha 1-3]Glc (A-pentasaccharide) and 1-3[Fuc alpha 1-4]GlcNAc beta 1-3Gal beta 1-4Glc (A-heptasaccharide) have previously found in urine, whereas GalNAc alpha 1-3[Fuc alpha 1-2]Gal beta 1-3GlcNAc beta 1-3Gal beta 1-4Glc (A-hexasaccharide) is a new compound. Structures were deduced by mass spectrometry of permethylated and N-trifluoroacetylated oligosaccharide alditols. The latter gave more structural information than the corresponding N-acetyl derivatives. The four oligosaccharides were tested for blood group A activity and all were found to inhibit the binding of anti-A antibody to blood group A substance.},
  author       = {Sabharwal, H and Nilsson, B and Chester, Alan and Sjöblad, Sture and Lundblad, A},
  issn         = {1872-9142},
  language     = {eng},
  number       = {11},
  pages        = {1105--1112},
  publisher    = {Pergamon},
  series       = {Molecular Immunology},
  title        = {Blood group specific oligosaccharides from faeces of a blood group A breast-fed infant},
  url          = {http://dx.doi.org/10.1016/0161-5890(84)90121-4},
  volume       = {21},
  year         = {1984},
}