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Proliferative synovitis in rabbit knee joints induced by antigen and preformed immune complexes

Thomsen, P; Bjursten, Lars Magnus LU ; Ahlstedt, S; Bagge, U and Ericson, L E (1985) In Scandinavian Journal of Rheumatology 14(3). p.239-251
Abstract
Knee joints of non-immunized rabbits were repeatedly injected with bovine serum albumin (BSA) and preformed BSA-anti-BSA immune complexes which had differing precipitation profiles and abilities to activate complement. Ten days after the last of six injections the antibody and lymphoproliferative responses to BSA were analysed and correlated to the degree of arthritis. Joint swelling, increased numbers of joint fluid leukocytes and morphological changes typical of proliferative synovitis were found only in those rabbits injected with a large dose of antigen or with immune complexes prepared in antigen excess of poor precipitation and complement-activating properties in vitro. The degree of arthritis correlated with the development of... (More)
Knee joints of non-immunized rabbits were repeatedly injected with bovine serum albumin (BSA) and preformed BSA-anti-BSA immune complexes which had differing precipitation profiles and abilities to activate complement. Ten days after the last of six injections the antibody and lymphoproliferative responses to BSA were analysed and correlated to the degree of arthritis. Joint swelling, increased numbers of joint fluid leukocytes and morphological changes typical of proliferative synovitis were found only in those rabbits injected with a large dose of antigen or with immune complexes prepared in antigen excess of poor precipitation and complement-activating properties in vitro. The degree of arthritis correlated with the development of humoral and lymphoproliferative immune responses to BSA. (Less)
Please use this url to cite or link to this publication:
author
publishing date
type
Contribution to journal
publication status
published
subject
in
Scandinavian Journal of Rheumatology
volume
14
issue
3
pages
239 - 251
publisher
Taylor & Francis
external identifiers
  • pmid:4048873
  • scopus:0021934754
ISSN
1502-7732
DOI
10.3109/03009748509100401
language
English
LU publication?
no
id
7188babf-efc4-4674-85ac-7db2d4e9d464 (old id 1103366)
date added to LUP
2008-08-11 12:45:56
date last changed
2017-01-01 04:21:33
@article{7188babf-efc4-4674-85ac-7db2d4e9d464,
  abstract     = {Knee joints of non-immunized rabbits were repeatedly injected with bovine serum albumin (BSA) and preformed BSA-anti-BSA immune complexes which had differing precipitation profiles and abilities to activate complement. Ten days after the last of six injections the antibody and lymphoproliferative responses to BSA were analysed and correlated to the degree of arthritis. Joint swelling, increased numbers of joint fluid leukocytes and morphological changes typical of proliferative synovitis were found only in those rabbits injected with a large dose of antigen or with immune complexes prepared in antigen excess of poor precipitation and complement-activating properties in vitro. The degree of arthritis correlated with the development of humoral and lymphoproliferative immune responses to BSA.},
  author       = {Thomsen, P and Bjursten, Lars Magnus and Ahlstedt, S and Bagge, U and Ericson, L E},
  issn         = {1502-7732},
  language     = {eng},
  number       = {3},
  pages        = {239--251},
  publisher    = {Taylor & Francis},
  series       = {Scandinavian Journal of Rheumatology},
  title        = {Proliferative synovitis in rabbit knee joints induced by antigen and preformed immune complexes},
  url          = {http://dx.doi.org/10.3109/03009748509100401},
  volume       = {14},
  year         = {1985},
}