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Chlorhexidine for prevention of neonatal colonization with group B streptococci. III. Effect of vaginal washing with chlorhexidine before rupture of the membranes

Kvist Christensen, K; Christensen, Poul; Dykes, Anna-Karin LU and Kahlmeter, Gunnar (1985) In European Journal of Obstetrics, Gynecology, and Reproductive Biology 19(4). p.231-236
Abstract
A single vaginal washing with 2 g/l of chlorhexidine was performed before rupture of the membranes in 19 parturients who were urogenital carriers of group B streptococci (GBS). Two (11%) of the infants became colonized immediately after birth, in contrast to 16 of 41 (39%) infants to controls (P = 0.02). A significant reduction of GBS colonization of the ear (P = 0.02) and umbilicus (P = 0.01) was noted. Taken together, 2 of 57 (4%) cultures obtained at birth were positive in the chlorhexidine group, in contrast to 30 of 123 (24%) among the controls (P less than 0.01). These findings raise hope for the design of a simple washing procedure which might prevent serious infections in the early neonatal period with GBS but also with other... (More)
A single vaginal washing with 2 g/l of chlorhexidine was performed before rupture of the membranes in 19 parturients who were urogenital carriers of group B streptococci (GBS). Two (11%) of the infants became colonized immediately after birth, in contrast to 16 of 41 (39%) infants to controls (P = 0.02). A significant reduction of GBS colonization of the ear (P = 0.02) and umbilicus (P = 0.01) was noted. Taken together, 2 of 57 (4%) cultures obtained at birth were positive in the chlorhexidine group, in contrast to 30 of 123 (24%) among the controls (P less than 0.01). These findings raise hope for the design of a simple washing procedure which might prevent serious infections in the early neonatal period with GBS but also with other chlorhexidine-sensitive organisms. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
neonatal colonization, group B streptococci, chlorhexidine
in
European Journal of Obstetrics, Gynecology, and Reproductive Biology
volume
19
issue
4
pages
231 - 236
publisher
Elsevier
external identifiers
  • pmid:3891445
  • scopus:0021800038
ISSN
0301-2115
DOI
10.1016/0028-2243(85)90034-6
language
English
LU publication?
yes
id
aad081a2-0e09-45a4-b47d-3bf53e016cc5 (old id 1103482)
date added to LUP
2008-08-11 14:33:42
date last changed
2017-01-01 05:10:25
@article{aad081a2-0e09-45a4-b47d-3bf53e016cc5,
  abstract     = {A single vaginal washing with 2 g/l of chlorhexidine was performed before rupture of the membranes in 19 parturients who were urogenital carriers of group B streptococci (GBS). Two (11%) of the infants became colonized immediately after birth, in contrast to 16 of 41 (39%) infants to controls (P = 0.02). A significant reduction of GBS colonization of the ear (P = 0.02) and umbilicus (P = 0.01) was noted. Taken together, 2 of 57 (4%) cultures obtained at birth were positive in the chlorhexidine group, in contrast to 30 of 123 (24%) among the controls (P less than 0.01). These findings raise hope for the design of a simple washing procedure which might prevent serious infections in the early neonatal period with GBS but also with other chlorhexidine-sensitive organisms.},
  author       = {Kvist Christensen, K and Christensen, Poul and Dykes, Anna-Karin and Kahlmeter, Gunnar},
  issn         = {0301-2115},
  keyword      = {neonatal colonization,group B streptococci,chlorhexidine},
  language     = {eng},
  number       = {4},
  pages        = {231--236},
  publisher    = {Elsevier},
  series       = {European Journal of Obstetrics, Gynecology, and Reproductive Biology},
  title        = {Chlorhexidine for prevention of neonatal colonization with group B streptococci. III. Effect of vaginal washing with chlorhexidine before rupture of the membranes},
  url          = {http://dx.doi.org/10.1016/0028-2243(85)90034-6},
  volume       = {19},
  year         = {1985},
}