Implants in the abdominal wall of the rat
(1986) In Scandinavian Journal of Plastic and Reconstructive Surgery 20(2). p.173-182- Abstract
- An experimental model is presented that allows qualitative as well as quantitative studies of the soft tissue response to implant materials used in reconstructive surgery. Plugs of non-alloyed titanium and polymers (Teflon, Delrin) were inserted into the abdominal wall of rats, with a portion of the plug penetrating through the peritoneum into the abdominal cavity. The tissue reaction was evaluated by means of light and electron microscopy for up to 9 weeks after insertion. Titanium implants were in direct contact with the connective tissue without intervening inflammatory cells. The defect in the peritoneum was sealed by a close apposition of the mesothelial membrane to the titanium surface and no connective tissue surrounded the... (More)
- An experimental model is presented that allows qualitative as well as quantitative studies of the soft tissue response to implant materials used in reconstructive surgery. Plugs of non-alloyed titanium and polymers (Teflon, Delrin) were inserted into the abdominal wall of rats, with a portion of the plug penetrating through the peritoneum into the abdominal cavity. The tissue reaction was evaluated by means of light and electron microscopy for up to 9 weeks after insertion. Titanium implants were in direct contact with the connective tissue without intervening inflammatory cells. The defect in the peritoneum was sealed by a close apposition of the mesothelial membrane to the titanium surface and no connective tissue surrounded the intra-peritoneal portion of the plug. In contrast, a fibrous capsule surrounded the intra-peritoneal portion of Teflon and Delrin implants. A reactive zone consisting of active macrophages and giant cells was present at the surface of these implants separating the implant from the surrounding fibrous capsule. This study shows that the tissue response at the interface to foreign materials can be studied using light and electron microscopic techniques and that profound differences in tissue response exist between different materials. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1103510
- author
- Thomsen, Peter ; Bjursten, Lars Magnus LU and Ericson, Lars E
- organization
- publishing date
- 1986
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Scandinavian Journal of Plastic and Reconstructive Surgery
- volume
- 20
- issue
- 2
- pages
- 173 - 182
- publisher
- Taylor & Francis
- external identifiers
-
- pmid:2948276
- scopus:0022535461
- ISSN
- 0036-5556
- DOI
- 10.3109/02844318609006316
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Bioimplant Research (013242910)
- id
- 143cbe48-6d8f-4238-9dbc-520727c6291d (old id 1103510)
- date added to LUP
- 2016-04-01 17:04:47
- date last changed
- 2021-01-03 11:19:18
@article{143cbe48-6d8f-4238-9dbc-520727c6291d,
abstract = {{An experimental model is presented that allows qualitative as well as quantitative studies of the soft tissue response to implant materials used in reconstructive surgery. Plugs of non-alloyed titanium and polymers (Teflon, Delrin) were inserted into the abdominal wall of rats, with a portion of the plug penetrating through the peritoneum into the abdominal cavity. The tissue reaction was evaluated by means of light and electron microscopy for up to 9 weeks after insertion. Titanium implants were in direct contact with the connective tissue without intervening inflammatory cells. The defect in the peritoneum was sealed by a close apposition of the mesothelial membrane to the titanium surface and no connective tissue surrounded the intra-peritoneal portion of the plug. In contrast, a fibrous capsule surrounded the intra-peritoneal portion of Teflon and Delrin implants. A reactive zone consisting of active macrophages and giant cells was present at the surface of these implants separating the implant from the surrounding fibrous capsule. This study shows that the tissue response at the interface to foreign materials can be studied using light and electron microscopic techniques and that profound differences in tissue response exist between different materials.}},
author = {{Thomsen, Peter and Bjursten, Lars Magnus and Ericson, Lars E}},
issn = {{0036-5556}},
language = {{eng}},
number = {{2}},
pages = {{173--182}},
publisher = {{Taylor & Francis}},
series = {{Scandinavian Journal of Plastic and Reconstructive Surgery}},
title = {{Implants in the abdominal wall of the rat}},
url = {{http://dx.doi.org/10.3109/02844318609006316}},
doi = {{10.3109/02844318609006316}},
volume = {{20}},
year = {{1986}},
}