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Implants in the abdominal wall of the rat

Thomsen, Peter; Bjursten, Lars Magnus LU and Ericson, Lars E (1986) In Scandinavian Journal of Plastic and Reconstructive Surgery 20(2). p.173-182
Abstract
An experimental model is presented that allows qualitative as well as quantitative studies of the soft tissue response to implant materials used in reconstructive surgery. Plugs of non-alloyed titanium and polymers (Teflon, Delrin) were inserted into the abdominal wall of rats, with a portion of the plug penetrating through the peritoneum into the abdominal cavity. The tissue reaction was evaluated by means of light and electron microscopy for up to 9 weeks after insertion. Titanium implants were in direct contact with the connective tissue without intervening inflammatory cells. The defect in the peritoneum was sealed by a close apposition of the mesothelial membrane to the titanium surface and no connective tissue surrounded the... (More)
An experimental model is presented that allows qualitative as well as quantitative studies of the soft tissue response to implant materials used in reconstructive surgery. Plugs of non-alloyed titanium and polymers (Teflon, Delrin) were inserted into the abdominal wall of rats, with a portion of the plug penetrating through the peritoneum into the abdominal cavity. The tissue reaction was evaluated by means of light and electron microscopy for up to 9 weeks after insertion. Titanium implants were in direct contact with the connective tissue without intervening inflammatory cells. The defect in the peritoneum was sealed by a close apposition of the mesothelial membrane to the titanium surface and no connective tissue surrounded the intra-peritoneal portion of the plug. In contrast, a fibrous capsule surrounded the intra-peritoneal portion of Teflon and Delrin implants. A reactive zone consisting of active macrophages and giant cells was present at the surface of these implants separating the implant from the surrounding fibrous capsule. This study shows that the tissue response at the interface to foreign materials can be studied using light and electron microscopic techniques and that profound differences in tissue response exist between different materials. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Scandinavian Journal of Plastic and Reconstructive Surgery
volume
20
issue
2
pages
173 - 182
publisher
Scandinavian University Press
external identifiers
  • pmid:2948276
  • scopus:0022535461
ISSN
0036-5556
DOI
10.3109/02844318609006316
language
English
LU publication?
yes
id
143cbe48-6d8f-4238-9dbc-520727c6291d (old id 1103510)
date added to LUP
2008-08-11 08:47:05
date last changed
2017-05-28 04:29:29
@article{143cbe48-6d8f-4238-9dbc-520727c6291d,
  abstract     = {An experimental model is presented that allows qualitative as well as quantitative studies of the soft tissue response to implant materials used in reconstructive surgery. Plugs of non-alloyed titanium and polymers (Teflon, Delrin) were inserted into the abdominal wall of rats, with a portion of the plug penetrating through the peritoneum into the abdominal cavity. The tissue reaction was evaluated by means of light and electron microscopy for up to 9 weeks after insertion. Titanium implants were in direct contact with the connective tissue without intervening inflammatory cells. The defect in the peritoneum was sealed by a close apposition of the mesothelial membrane to the titanium surface and no connective tissue surrounded the intra-peritoneal portion of the plug. In contrast, a fibrous capsule surrounded the intra-peritoneal portion of Teflon and Delrin implants. A reactive zone consisting of active macrophages and giant cells was present at the surface of these implants separating the implant from the surrounding fibrous capsule. This study shows that the tissue response at the interface to foreign materials can be studied using light and electron microscopic techniques and that profound differences in tissue response exist between different materials.},
  author       = {Thomsen, Peter and Bjursten, Lars Magnus and Ericson, Lars E},
  issn         = {0036-5556},
  language     = {eng},
  number       = {2},
  pages        = {173--182},
  publisher    = {Scandinavian University Press},
  series       = {Scandinavian Journal of Plastic and Reconstructive Surgery},
  title        = {Implants in the abdominal wall of the rat},
  url          = {http://dx.doi.org/10.3109/02844318609006316},
  volume       = {20},
  year         = {1986},
}