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Disuse as cause of supersensitivity in the rat urinary bladder

Ekström, J and Malmberg, Lars LU (1986) In Acta Physiologica Scandinavica 126(3). p.429-432
Abstract
Ureterostomia in situ was performed to reduce the nervous reflex activation of the bladders without concomitant hypertrophy. In muscle strips of these disused and non-hypertrophied bladders, supersensitivity to methacholine was demonstrated, which did not increase between 1 and 3 weeks. The supersensitivity did not increase further by combining urinary diversion with section of the preganglionic bladder nerves (decentralization). From the present results it may be concluded that in decentralized and hypertrophied bladders not only hypertrophy per se, previously studied (Ekstrom et al. 1985), but also loss of nerve impulse traffic (cf. urinary diversion) contribute to the development of supersensitivity.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Physiologica Scandinavica
volume
126
issue
3
pages
429 - 432
publisher
Wiley-Blackwell
external identifiers
  • pmid:3515849
  • scopus:0022517968
ISSN
0001-6772
language
English
LU publication?
yes
id
b679fa44-6f20-4f90-8913-03e8b1ed88ca (old id 1103620)
date added to LUP
2008-08-11 09:59:31
date last changed
2017-02-22 11:44:23
@article{b679fa44-6f20-4f90-8913-03e8b1ed88ca,
  abstract     = {Ureterostomia in situ was performed to reduce the nervous reflex activation of the bladders without concomitant hypertrophy. In muscle strips of these disused and non-hypertrophied bladders, supersensitivity to methacholine was demonstrated, which did not increase between 1 and 3 weeks. The supersensitivity did not increase further by combining urinary diversion with section of the preganglionic bladder nerves (decentralization). From the present results it may be concluded that in decentralized and hypertrophied bladders not only hypertrophy per se, previously studied (Ekstrom et al. 1985), but also loss of nerve impulse traffic (cf. urinary diversion) contribute to the development of supersensitivity.},
  author       = {Ekström, J and Malmberg, Lars},
  issn         = {0001-6772},
  language     = {eng},
  number       = {3},
  pages        = {429--432},
  publisher    = {Wiley-Blackwell},
  series       = {Acta Physiologica Scandinavica},
  title        = {Disuse as cause of supersensitivity in the rat urinary bladder},
  volume       = {126},
  year         = {1986},
}