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EEG depression and germinal layer haemorrhage in the newborn

Greisen, G; Hellström-Westas, Lena LU ; Lou, H; Rosén, Ingmar LU and Svenningsen, N W (1987) In Acta Paediatrica Scandinavica 76(3). p.519-525
Abstract
Amplitude integrated EEG (aEEG) recordings from 32 mechanically ventilated infants, gestational age 32 weeks or less, were analysed. All recordings were started within 24 h of birth and continued for at least 50 h. Germinal layer haemorrhage (GLH) was diagnosed by repeated ultrasonography. In six infants neither GLH nor hypocalcaemia were diagnosed; aEEG in these infants rapidly became more active after birth: at 30 h of age continuous background activity was present for more than 20% of the time, and a seizure-like pattern was exceptional. In seven infants without GLH but with hypocalcaemia and other signs of metabolic derangement, continuous background activity appeared later and seizure-like activity was frequent. In the infants with... (More)
Amplitude integrated EEG (aEEG) recordings from 32 mechanically ventilated infants, gestational age 32 weeks or less, were analysed. All recordings were started within 24 h of birth and continued for at least 50 h. Germinal layer haemorrhage (GLH) was diagnosed by repeated ultrasonography. In six infants neither GLH nor hypocalcaemia were diagnosed; aEEG in these infants rapidly became more active after birth: at 30 h of age continuous background activity was present for more than 20% of the time, and a seizure-like pattern was exceptional. In seven infants without GLH but with hypocalcaemia and other signs of metabolic derangement, continuous background activity appeared later and seizure-like activity was frequent. In the infants with GLH, depression of the background activity was apparent. This finding was particularly distinct in the presence of severe haemorrhages. Four infants developed GLH after 30 h of age. All these infants had depressed aEEG before the development of GLH, with less than 20% continuous activity at 30 h of age. In ten infants an analysis of the aEEG during the occurrence of GLH was possible. In six of these, cortical electrical activity decreased. Due to the limitation of GLH timing, it was not possible to decide whether this decrease closely preceded or followed GLH. We suggest that GLH primarily occurs in brains with a preceding metabolic and neurophysiologic abnormality, and that further functional deterioration is caused by the most severe haemorrhages. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
preterm infant, cerebral haemorrhage, electroencephalogram, hypocalcaemia
in
Acta Paediatrica Scandinavica
volume
76
issue
3
pages
519 - 525
publisher
Taylor & Francis
external identifiers
  • pmid:3604671
  • scopus:0023194362
ISSN
0001-656X
DOI
10.1111/j.1651-2227.1987.tb10509.x
language
English
LU publication?
yes
id
f953b587-0e49-4014-b024-a0bef18bd822 (old id 1103731)
date added to LUP
2008-08-08 11:57:07
date last changed
2017-08-06 04:23:50
@article{f953b587-0e49-4014-b024-a0bef18bd822,
  abstract     = {Amplitude integrated EEG (aEEG) recordings from 32 mechanically ventilated infants, gestational age 32 weeks or less, were analysed. All recordings were started within 24 h of birth and continued for at least 50 h. Germinal layer haemorrhage (GLH) was diagnosed by repeated ultrasonography. In six infants neither GLH nor hypocalcaemia were diagnosed; aEEG in these infants rapidly became more active after birth: at 30 h of age continuous background activity was present for more than 20% of the time, and a seizure-like pattern was exceptional. In seven infants without GLH but with hypocalcaemia and other signs of metabolic derangement, continuous background activity appeared later and seizure-like activity was frequent. In the infants with GLH, depression of the background activity was apparent. This finding was particularly distinct in the presence of severe haemorrhages. Four infants developed GLH after 30 h of age. All these infants had depressed aEEG before the development of GLH, with less than 20% continuous activity at 30 h of age. In ten infants an analysis of the aEEG during the occurrence of GLH was possible. In six of these, cortical electrical activity decreased. Due to the limitation of GLH timing, it was not possible to decide whether this decrease closely preceded or followed GLH. We suggest that GLH primarily occurs in brains with a preceding metabolic and neurophysiologic abnormality, and that further functional deterioration is caused by the most severe haemorrhages.},
  author       = {Greisen, G and Hellström-Westas, Lena and Lou, H and Rosén, Ingmar and Svenningsen, N W},
  issn         = {0001-656X},
  keyword      = {preterm infant,cerebral haemorrhage,electroencephalogram,hypocalcaemia},
  language     = {eng},
  number       = {3},
  pages        = {519--525},
  publisher    = {Taylor & Francis},
  series       = {Acta Paediatrica Scandinavica},
  title        = {EEG depression and germinal layer haemorrhage in the newborn},
  url          = {http://dx.doi.org/10.1111/j.1651-2227.1987.tb10509.x},
  volume       = {76},
  year         = {1987},
}