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Controlled trial of a short and a prolonged course with ciprofloxacin in patients undergoing transurethral prostatic surgery

Grabe, Magnus LU ; Forsgren, Arne LU ; Björk, Thomas LU and Hellsten, Sverker LU (1987) In European journal of clinical microbiology & infectious diseases1987-01-01+01:00 6(1). p.11-17
Abstract
The efficacy of a short (Group I) and a prolonged (Group II) course with ciprofloxacin was assessed in patients undergoing transurethral prostatic resection for benign hyperplasia or cancer of the prostate and compared with that of controls without antibiotic (Group III). Both regiments significantly reduced the frequency of postoperative bacteriuria (p less than 0.01) and of severe infectious complications (p = 0.004) as compared to the controls. Both regimens were equally effective in preventing perioperative and postoperative acquisition of bacteriuria in patients without bacteriuria at surgery. In patients with bacteriuria before surgery, bacteriuria was found postoperatively in 35% in Group I and 10% in Group II (p = 0.012), but in... (More)
The efficacy of a short (Group I) and a prolonged (Group II) course with ciprofloxacin was assessed in patients undergoing transurethral prostatic resection for benign hyperplasia or cancer of the prostate and compared with that of controls without antibiotic (Group III). Both regiments significantly reduced the frequency of postoperative bacteriuria (p less than 0.01) and of severe infectious complications (p = 0.004) as compared to the controls. Both regimens were equally effective in preventing perioperative and postoperative acquisition of bacteriuria in patients without bacteriuria at surgery. In patients with bacteriuria before surgery, bacteriuria was found postoperatively in 35% in Group I and 10% in Group II (p = 0.012), but in 82% of the patients in Group III. Ciprofloxacin inhibited all but 7 of 176 bacterial strains at an MIC of less than or equal to 1 microgram/ml. Given orally ciprofloxacin is a valuable alternative antimicrobial for use in conjunction with transurethral prostatic resection. A short course is sufficient for prophylaxis, and adequate therapy is achieved with a prolonged regimen. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
European journal of clinical microbiology & infectious diseases1987-01-01+01:00
volume
6
issue
1
pages
11 - 17
publisher
Springer
external identifiers
  • pmid:3569248
  • scopus:0023112882
ISSN
0722-2211
DOI
10.1007/BF02097183
language
English
LU publication?
yes
id
bf10cef2-47ff-4f90-b59c-3ab5dc6d00df (old id 1103783)
date added to LUP
2008-08-08 12:43:35
date last changed
2017-07-30 04:42:19
@article{bf10cef2-47ff-4f90-b59c-3ab5dc6d00df,
  abstract     = {The efficacy of a short (Group I) and a prolonged (Group II) course with ciprofloxacin was assessed in patients undergoing transurethral prostatic resection for benign hyperplasia or cancer of the prostate and compared with that of controls without antibiotic (Group III). Both regiments significantly reduced the frequency of postoperative bacteriuria (p less than 0.01) and of severe infectious complications (p = 0.004) as compared to the controls. Both regimens were equally effective in preventing perioperative and postoperative acquisition of bacteriuria in patients without bacteriuria at surgery. In patients with bacteriuria before surgery, bacteriuria was found postoperatively in 35% in Group I and 10% in Group II (p = 0.012), but in 82% of the patients in Group III. Ciprofloxacin inhibited all but 7 of 176 bacterial strains at an MIC of less than or equal to 1 microgram/ml. Given orally ciprofloxacin is a valuable alternative antimicrobial for use in conjunction with transurethral prostatic resection. A short course is sufficient for prophylaxis, and adequate therapy is achieved with a prolonged regimen.},
  author       = {Grabe, Magnus and Forsgren, Arne and Björk, Thomas and Hellsten, Sverker},
  issn         = {0722-2211},
  language     = {eng},
  number       = {1},
  pages        = {11--17},
  publisher    = {Springer},
  series       = {European journal of clinical microbiology & infectious diseases1987-01-01+01:00},
  title        = {Controlled trial of a short and a prolonged course with ciprofloxacin in patients undergoing transurethral prostatic surgery},
  url          = {http://dx.doi.org/10.1007/BF02097183},
  volume       = {6},
  year         = {1987},
}