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Influence of standard heparin or low molecular weight heparin on healing of abdominal wounds and colonic anastomoses in rats

Mätzsch, Thomas LU ; Bergqvist, D; Blomquist, Peter LU and Jiborn, H (1987) In Acta Chirurgica Scandinavica 153(10). p.593-598
Abstract
The influence of standard heparin or low molecular weight (LMW) heparin on healing of abdominal wounds and colonic anastomoses was studied in rats. Subcutaneous injection of 1 XaI U/g b.w. of standard or LMW-heparin or 0.5 ml physiologic saline was given 12 hours preoperatively and daily for 3 or 7 days postoperatively. Breaking strength of the abdominal wound and the anastomosis was measured, as were haemoglobin and albumin in serum. Hydroxyproline as a measure of collagen and tissue dry weight was determined in standardized segments of colonic wall adjacent to the anastomosis. Except for significant increase in breaking strength of the anastomosis after 7-day injection of LMW heparin, no differences in the parameters of wound healing... (More)
The influence of standard heparin or low molecular weight (LMW) heparin on healing of abdominal wounds and colonic anastomoses was studied in rats. Subcutaneous injection of 1 XaI U/g b.w. of standard or LMW-heparin or 0.5 ml physiologic saline was given 12 hours preoperatively and daily for 3 or 7 days postoperatively. Breaking strength of the abdominal wound and the anastomosis was measured, as were haemoglobin and albumin in serum. Hydroxyproline as a measure of collagen and tissue dry weight was determined in standardized segments of colonic wall adjacent to the anastomosis. Except for significant increase in breaking strength of the anastomosis after 7-day injection of LMW heparin, no differences in the parameters of wound healing were found after 3 or 7 days. In rats receiving standard heparin there was increased bleeding tendency (reduced haemoglobin) compared with the LMW-heparin group and the controls. The administered heparin thus did not negatively influence healing, and standard and LMW-heparin did not differ in this respect. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Chirurgica Scandinavica
volume
153
issue
10
pages
593 - 598
publisher
Almqvist & Wiksell
external identifiers
  • pmid:2829481
  • scopus:0023518634
ISSN
0001-5482
language
English
LU publication?
yes
id
d08aae04-a5d3-4b1d-beb9-3a4d32d2e04b (old id 1103886)
date added to LUP
2008-08-08 15:48:29
date last changed
2017-08-27 05:39:07
@article{d08aae04-a5d3-4b1d-beb9-3a4d32d2e04b,
  abstract     = {The influence of standard heparin or low molecular weight (LMW) heparin on healing of abdominal wounds and colonic anastomoses was studied in rats. Subcutaneous injection of 1 XaI U/g b.w. of standard or LMW-heparin or 0.5 ml physiologic saline was given 12 hours preoperatively and daily for 3 or 7 days postoperatively. Breaking strength of the abdominal wound and the anastomosis was measured, as were haemoglobin and albumin in serum. Hydroxyproline as a measure of collagen and tissue dry weight was determined in standardized segments of colonic wall adjacent to the anastomosis. Except for significant increase in breaking strength of the anastomosis after 7-day injection of LMW heparin, no differences in the parameters of wound healing were found after 3 or 7 days. In rats receiving standard heparin there was increased bleeding tendency (reduced haemoglobin) compared with the LMW-heparin group and the controls. The administered heparin thus did not negatively influence healing, and standard and LMW-heparin did not differ in this respect.},
  author       = {Mätzsch, Thomas and Bergqvist, D and Blomquist, Peter and Jiborn, H},
  issn         = {0001-5482},
  language     = {eng},
  number       = {10},
  pages        = {593--598},
  publisher    = {Almqvist & Wiksell},
  series       = {Acta Chirurgica Scandinavica},
  title        = {Influence of standard heparin or low molecular weight heparin on healing of abdominal wounds and colonic anastomoses in rats},
  volume       = {153},
  year         = {1987},
}