Disturbed pubertal growth in girls treated for acute lymphoblastic leukemia
(1987) In Pediatric Hematology & Oncology 4(1). p.1-5- Abstract
- Pubertal growth was studied in 10 girls previously treated for acute lymphoblastic leukemia. The average age at menarche was 12.2 years, which is significantly lower (p less than 0.01) than the expected 13.1 years. Compared with normal girls, these girls showed a subnormal (p less than 0.05) peak height velocity during the second year before menarche. The remaining growth before menarche as well as the total postmenarchal growth was close to the normal average. The average final standing height was 1 SD less than what would be expected from their height 1 year after the cessation of therapy. A relative growth hormone deficiency in combination with early onset of puberty could account for this loss in final height.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1103925
- author
- Moëll, Christian LU ; Garwicz, Stanislaw LU ; Westgren, Ulf LU and Wiebe, Thomas LU
- organization
- publishing date
- 1987
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- acute lymphoblastic leukemia, children, growth, puberty, growth hormone, irradiation, menarche
- in
- Pediatric Hematology & Oncology
- volume
- 4
- issue
- 1
- pages
- 1 - 5
- publisher
- Hemisphere Pub. Corp.
- external identifiers
-
- pmid:3152908
- scopus:0023179288
- ISSN
- 1521-0669
- DOI
- 10.3109/08880018709141243
- language
- English
- LU publication?
- yes
- id
- 37956ad4-efdb-45ea-871c-6b58c6520473 (old id 1103925)
- date added to LUP
- 2016-04-01 12:31:42
- date last changed
- 2021-09-19 04:02:51
@article{37956ad4-efdb-45ea-871c-6b58c6520473, abstract = {{Pubertal growth was studied in 10 girls previously treated for acute lymphoblastic leukemia. The average age at menarche was 12.2 years, which is significantly lower (p less than 0.01) than the expected 13.1 years. Compared with normal girls, these girls showed a subnormal (p less than 0.05) peak height velocity during the second year before menarche. The remaining growth before menarche as well as the total postmenarchal growth was close to the normal average. The average final standing height was 1 SD less than what would be expected from their height 1 year after the cessation of therapy. A relative growth hormone deficiency in combination with early onset of puberty could account for this loss in final height.}}, author = {{Moëll, Christian and Garwicz, Stanislaw and Westgren, Ulf and Wiebe, Thomas}}, issn = {{1521-0669}}, keywords = {{acute lymphoblastic leukemia; children; growth; puberty; growth hormone; irradiation; menarche}}, language = {{eng}}, number = {{1}}, pages = {{1--5}}, publisher = {{Hemisphere Pub. Corp.}}, series = {{Pediatric Hematology & Oncology}}, title = {{Disturbed pubertal growth in girls treated for acute lymphoblastic leukemia}}, url = {{http://dx.doi.org/10.3109/08880018709141243}}, doi = {{10.3109/08880018709141243}}, volume = {{4}}, year = {{1987}}, }