Advanced

Disturbed pubertal growth in girls treated for acute lymphoblastic leukemia

Moëll, Christian LU ; Garwicz, Stanislaw LU ; Westgren, Ulf LU and Wiebe, Thomas LU (1987) In Pediatric Hematology & Oncology 4(1). p.1-5
Abstract
Pubertal growth was studied in 10 girls previously treated for acute lymphoblastic leukemia. The average age at menarche was 12.2 years, which is significantly lower (p less than 0.01) than the expected 13.1 years. Compared with normal girls, these girls showed a subnormal (p less than 0.05) peak height velocity during the second year before menarche. The remaining growth before menarche as well as the total postmenarchal growth was close to the normal average. The average final standing height was 1 SD less than what would be expected from their height 1 year after the cessation of therapy. A relative growth hormone deficiency in combination with early onset of puberty could account for this loss in final height.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
acute lymphoblastic leukemia, children, growth, puberty, growth hormone, irradiation, menarche
in
Pediatric Hematology & Oncology
volume
4
issue
1
pages
1 - 5
publisher
Hemisphere Pub. Corp.
external identifiers
  • pmid:3152908
  • scopus:0023179288
ISSN
1521-0669
DOI
10.3109/08880018709141243
language
English
LU publication?
yes
id
37956ad4-efdb-45ea-871c-6b58c6520473 (old id 1103925)
date added to LUP
2008-08-08 16:33:09
date last changed
2017-03-19 03:38:12
@article{37956ad4-efdb-45ea-871c-6b58c6520473,
  abstract     = {Pubertal growth was studied in 10 girls previously treated for acute lymphoblastic leukemia. The average age at menarche was 12.2 years, which is significantly lower (p less than 0.01) than the expected 13.1 years. Compared with normal girls, these girls showed a subnormal (p less than 0.05) peak height velocity during the second year before menarche. The remaining growth before menarche as well as the total postmenarchal growth was close to the normal average. The average final standing height was 1 SD less than what would be expected from their height 1 year after the cessation of therapy. A relative growth hormone deficiency in combination with early onset of puberty could account for this loss in final height.},
  author       = {Moëll, Christian and Garwicz, Stanislaw and Westgren, Ulf and Wiebe, Thomas},
  issn         = {1521-0669},
  keyword      = {acute lymphoblastic leukemia,children,growth,puberty,growth hormone,irradiation,menarche},
  language     = {eng},
  number       = {1},
  pages        = {1--5},
  publisher    = {Hemisphere Pub. Corp.},
  series       = {Pediatric Hematology & Oncology},
  title        = {Disturbed pubertal growth in girls treated for acute lymphoblastic leukemia},
  url          = {http://dx.doi.org/10.3109/08880018709141243},
  volume       = {4},
  year         = {1987},
}