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Increase in hepatic lipase activity after testosterone substitution in men with hypogonadism of pituitary origin

Valdemarsson, Stig LU ; Hedner, P and Nilsson-Ehle, Peter LU (1987) In Acta Medica Scandinavica 221(4). p.363-366
Abstract
Ten men with hypogonadism of pituitary origin were studied before and during testosterone substitution therapy with regard to effects on the activities of hepatic lipase (HL) and lipoprotein lipase (LPL) in postheparin plasma, and on plasma lipoprotein concentrations. The mean (+/- SEM) testosterone level increased from 1.8 +/- 0.5 to 16.3 +/- 2.4 nmol/l. The mean activity of HL rose from 327.1 +/- 35.2 to 432.8 +/- 57.2 mU/ml (p less than 0.02), while the activity of LPL did not change significantly, 71.0 +/- 9.1 mU/ml before and 62.2 +/- 3.8 mU/ml after treatment. No significant alterations in lipoprotein concentrations were recorded. These results indicate that a normal testosterone level is of importance for maintaining the activity of... (More)
Ten men with hypogonadism of pituitary origin were studied before and during testosterone substitution therapy with regard to effects on the activities of hepatic lipase (HL) and lipoprotein lipase (LPL) in postheparin plasma, and on plasma lipoprotein concentrations. The mean (+/- SEM) testosterone level increased from 1.8 +/- 0.5 to 16.3 +/- 2.4 nmol/l. The mean activity of HL rose from 327.1 +/- 35.2 to 432.8 +/- 57.2 mU/ml (p less than 0.02), while the activity of LPL did not change significantly, 71.0 +/- 9.1 mU/ml before and 62.2 +/- 3.8 mU/ml after treatment. No significant alterations in lipoprotein concentrations were recorded. These results indicate that a normal testosterone level is of importance for maintaining the activity of HL in men, thereby contributing to the sex difference previously recorded for HL activity. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Medica Scandinavica
volume
221
issue
4
pages
363 - 366
publisher
Norstedts
external identifiers
  • pmid:3604752
  • scopus:0023227651
ISSN
0001-6101
language
English
LU publication?
yes
id
cdabe99f-a43f-4214-8248-bd41f772cffb (old id 1103965)
date added to LUP
2008-08-08 17:08:06
date last changed
2017-01-01 06:49:33
@article{cdabe99f-a43f-4214-8248-bd41f772cffb,
  abstract     = {Ten men with hypogonadism of pituitary origin were studied before and during testosterone substitution therapy with regard to effects on the activities of hepatic lipase (HL) and lipoprotein lipase (LPL) in postheparin plasma, and on plasma lipoprotein concentrations. The mean (+/- SEM) testosterone level increased from 1.8 +/- 0.5 to 16.3 +/- 2.4 nmol/l. The mean activity of HL rose from 327.1 +/- 35.2 to 432.8 +/- 57.2 mU/ml (p less than 0.02), while the activity of LPL did not change significantly, 71.0 +/- 9.1 mU/ml before and 62.2 +/- 3.8 mU/ml after treatment. No significant alterations in lipoprotein concentrations were recorded. These results indicate that a normal testosterone level is of importance for maintaining the activity of HL in men, thereby contributing to the sex difference previously recorded for HL activity.},
  author       = {Valdemarsson, Stig and Hedner, P and Nilsson-Ehle, Peter},
  issn         = {0001-6101},
  language     = {eng},
  number       = {4},
  pages        = {363--366},
  publisher    = {Norstedts},
  series       = {Acta Medica Scandinavica},
  title        = {Increase in hepatic lipase activity after testosterone substitution in men with hypogonadism of pituitary origin},
  volume       = {221},
  year         = {1987},
}