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Increased uptake of 5-FU in experimental liver tumours by simultaneous infusion of norepinephrine

Vagianos, Constantin; Puntis, Malcolm; Jeppsson, Bengt LU ; Steen, Stig LU ; Zoucas, Evita and Bengmark, Stig LU (1987) In European journal of cancer & clinical oncology 23(9). p.1323-1327
Abstract
The effect of the simultaneous administration of norepinephrine and 5-fluorouracil (5-FU) on the uptake of radiolabelled 5-FU by liver tumours was studied in rats. Three different concentrations of 5-FU were used (15, 1.5 and 0.15 microgram/g body weight). The drugs were infused over a 30 min period via the hepatic artery, following cannulation of the gastroduodenal artery. The radioactivity in liver tumour, normal liver, lungs and intestines was estimated by liquid scintillation counting. At all concentrations tested, an increased uptake of radioactive 5-FU was found in the tumour when norepinephrine was infused. Tumour/liver ratios also increased significantly in all these cases. No significant differences were noted between... (More)
The effect of the simultaneous administration of norepinephrine and 5-fluorouracil (5-FU) on the uptake of radiolabelled 5-FU by liver tumours was studied in rats. Three different concentrations of 5-FU were used (15, 1.5 and 0.15 microgram/g body weight). The drugs were infused over a 30 min period via the hepatic artery, following cannulation of the gastroduodenal artery. The radioactivity in liver tumour, normal liver, lungs and intestines was estimated by liquid scintillation counting. At all concentrations tested, an increased uptake of radioactive 5-FU was found in the tumour when norepinephrine was infused. Tumour/liver ratios also increased significantly in all these cases. No significant differences were noted between norepinephrine infused and control animals in the radioactivity in normal liver, lungs and intestines. The effects noted were possibly due to changes in blood flow within the liver, but the possibility of a direct effect of norepinephrine on DNA metabolism is discussed. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
European journal of cancer & clinical oncology
volume
23
issue
9
pages
1323 - 1327
publisher
Elsevier
external identifiers
  • pmid:3678326
  • scopus:0023502994
ISSN
0277-5379
DOI
10.1016/0277-5379(87)90115-5
language
English
LU publication?
yes
id
9ff98d5d-dd01-46ad-89f7-8904f79914e6 (old id 1103993)
date added to LUP
2008-08-08 17:26:54
date last changed
2017-07-09 04:26:47
@article{9ff98d5d-dd01-46ad-89f7-8904f79914e6,
  abstract     = {The effect of the simultaneous administration of norepinephrine and 5-fluorouracil (5-FU) on the uptake of radiolabelled 5-FU by liver tumours was studied in rats. Three different concentrations of 5-FU were used (15, 1.5 and 0.15 microgram/g body weight). The drugs were infused over a 30 min period via the hepatic artery, following cannulation of the gastroduodenal artery. The radioactivity in liver tumour, normal liver, lungs and intestines was estimated by liquid scintillation counting. At all concentrations tested, an increased uptake of radioactive 5-FU was found in the tumour when norepinephrine was infused. Tumour/liver ratios also increased significantly in all these cases. No significant differences were noted between norepinephrine infused and control animals in the radioactivity in normal liver, lungs and intestines. The effects noted were possibly due to changes in blood flow within the liver, but the possibility of a direct effect of norepinephrine on DNA metabolism is discussed.},
  author       = {Vagianos, Constantin and Puntis, Malcolm and Jeppsson, Bengt and Steen, Stig and Zoucas, Evita and Bengmark, Stig},
  issn         = {0277-5379},
  language     = {eng},
  number       = {9},
  pages        = {1323--1327},
  publisher    = {Elsevier},
  series       = {European journal of cancer & clinical oncology},
  title        = {Increased uptake of 5-FU in experimental liver tumours by simultaneous infusion of norepinephrine},
  url          = {http://dx.doi.org/10.1016/0277-5379(87)90115-5},
  volume       = {23},
  year         = {1987},
}