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Lidocaine for treatment of severe seizures in newborn infants. I. Clinical effects and cerebral electrical activity monitoring

Hellström-Westas, Lena LU ; Westgren, Ulf LU ; Rosén, Ingmar LU and Svenningsen, N W (1988) In Acta Paediatrica Scandinavica 77(1). p.79-84
Abstract
The anticonvulsive effect of lidocaine was evaluated in 46 newborn infants with severe, recurrent seizures. Before the lidocaine all infants were being given phenobarbital, and 22 infants were also treated with diazepam. Different dosages of lidocaine were tested. A loading dose of 2 mg/kg followed by i.v. infusion of 6 mg/kg/hour was the most effective dosage and had an immediate anticonvulsive effect in 18 of 25 infants; within 30 min the same effect was attained in another five of the infants, with an overall seizure control in 92% of the sample population. During the lidocaine treatment cerebral electrical activity was followed continuously with a cerebral function monitor (CFM), which also enabled evaluation of the treatment. No... (More)
The anticonvulsive effect of lidocaine was evaluated in 46 newborn infants with severe, recurrent seizures. Before the lidocaine all infants were being given phenobarbital, and 22 infants were also treated with diazepam. Different dosages of lidocaine were tested. A loading dose of 2 mg/kg followed by i.v. infusion of 6 mg/kg/hour was the most effective dosage and had an immediate anticonvulsive effect in 18 of 25 infants; within 30 min the same effect was attained in another five of the infants, with an overall seizure control in 92% of the sample population. During the lidocaine treatment cerebral electrical activity was followed continuously with a cerebral function monitor (CFM), which also enabled evaluation of the treatment. No serious side effects on blood-pressure, heart-rate or cerebral electrical activity were registered. For newborn infants with severe recurrent seizures not responding to other drugs, lidocaine is an effective additional mode of treatment. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
neonatal seizures, lidocaine, cerebral function monitoring
in
Acta Paediatrica Scandinavica
volume
77
issue
1
pages
79 - 84
publisher
Taylor & Francis
external identifiers
  • pmid:3369308
ISSN
0001-656X
DOI
10.1111/j.1651-2227.1988.tb10602.x
language
English
LU publication?
yes
id
4f7ecb24-5112-486d-9dbb-3e345909d764 (old id 1104054)
date added to LUP
2008-08-07 09:57:15
date last changed
2016-04-16 05:04:40
@article{4f7ecb24-5112-486d-9dbb-3e345909d764,
  abstract     = {The anticonvulsive effect of lidocaine was evaluated in 46 newborn infants with severe, recurrent seizures. Before the lidocaine all infants were being given phenobarbital, and 22 infants were also treated with diazepam. Different dosages of lidocaine were tested. A loading dose of 2 mg/kg followed by i.v. infusion of 6 mg/kg/hour was the most effective dosage and had an immediate anticonvulsive effect in 18 of 25 infants; within 30 min the same effect was attained in another five of the infants, with an overall seizure control in 92% of the sample population. During the lidocaine treatment cerebral electrical activity was followed continuously with a cerebral function monitor (CFM), which also enabled evaluation of the treatment. No serious side effects on blood-pressure, heart-rate or cerebral electrical activity were registered. For newborn infants with severe recurrent seizures not responding to other drugs, lidocaine is an effective additional mode of treatment.},
  author       = {Hellström-Westas, Lena and Westgren, Ulf and Rosén, Ingmar and Svenningsen, N W},
  issn         = {0001-656X},
  keyword      = {neonatal seizures,lidocaine,cerebral function monitoring},
  language     = {eng},
  number       = {1},
  pages        = {79--84},
  publisher    = {Taylor & Francis},
  series       = {Acta Paediatrica Scandinavica},
  title        = {Lidocaine for treatment of severe seizures in newborn infants. I. Clinical effects and cerebral electrical activity monitoring},
  url          = {http://dx.doi.org/10.1111/j.1651-2227.1988.tb10602.x},
  volume       = {77},
  year         = {1988},
}