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Clinical aspects of osseointegration in joint replacement. A histological study of titanium implants

Linder, L; Carlsson, Åke LU ; Marsal, L; Bjursten, Lars Magnus LU and Brånemark, P I (1988) In Journal of Bone and Joint Surgery 70-B(4). p.550-555
Abstract
In an experimental clinical study, 25 implants of pure titanium were inserted into the proximal tibia of 11 volunteer patients, four with rheumatoid arthritis and seven with osteoarthritis. The implants were removed from five weeks to 24 months later and detailed histological analysis was performed. The implants generally healed with direct bone-metal contact, showing so-called osseointegration. Only one of the 21 implants which had been in place for over five months did not show osseointegration, probably because of inadequate primary contact with bone. The presence of rheumatoid disease did not prevent osseointegration, but accompanying osteoporosis seemed to be a risk factor.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Bone and Joint Surgery
volume
70-B
issue
4
pages
550 - 555
publisher
British Editorial Society of Bone & Joint Surgery
external identifiers
  • pmid:3403596
  • scopus:0023765461
ISSN
2044-5377
language
English
LU publication?
yes
id
8d585088-822e-4b7f-a2dc-e2e7a8ed7113 (old id 1104068)
alternative location
http://www.jbjs.org.uk/cgi/reprint/70-B/4/550
date added to LUP
2008-08-07 10:05:51
date last changed
2017-10-08 03:28:28
@article{8d585088-822e-4b7f-a2dc-e2e7a8ed7113,
  abstract     = {In an experimental clinical study, 25 implants of pure titanium were inserted into the proximal tibia of 11 volunteer patients, four with rheumatoid arthritis and seven with osteoarthritis. The implants were removed from five weeks to 24 months later and detailed histological analysis was performed. The implants generally healed with direct bone-metal contact, showing so-called osseointegration. Only one of the 21 implants which had been in place for over five months did not show osseointegration, probably because of inadequate primary contact with bone. The presence of rheumatoid disease did not prevent osseointegration, but accompanying osteoporosis seemed to be a risk factor.},
  author       = {Linder, L and Carlsson, Åke and Marsal, L and Bjursten, Lars Magnus and Brånemark, P I},
  issn         = {2044-5377},
  language     = {eng},
  number       = {4},
  pages        = {550--555},
  publisher    = {British Editorial Society of Bone & Joint Surgery},
  series       = {Journal of Bone and Joint Surgery},
  title        = {Clinical aspects of osseointegration in joint replacement. A histological study of titanium implants},
  volume       = {70-B},
  year         = {1988},
}