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Differences in lodgement of tumour cells in muscle and liver

Blomqvist, G; Skolnik, G; Braide, M; Bjursten, Lars Magnus LU ; Blixt, A and Bagge, U (1988) In Clinical and Experimental Metastasis 6(4). p.285-289
Abstract
Differences in the lodgement of circulating tumour cells in various organs are considered an important factor in metastatic organ selection. The present vital microscopic studies show that the pattern of intravascular arrest of tumour cells in muscle after intra-arterial injection is similar to that observed earlier, in the liver, after intraportal injection. However, parallel isotope studies on the lodgement process (at 5 min and 3 h after injection) showed that the tumour cells trapped in the muscle microvasculature were destroyed at a higher rate than in the liver. Tumour cells kept in test tubes, and thus not being subjected to the shearing forces of the circulation, had a higher survival rate than cells trapped in the muscle. The... (More)
Differences in the lodgement of circulating tumour cells in various organs are considered an important factor in metastatic organ selection. The present vital microscopic studies show that the pattern of intravascular arrest of tumour cells in muscle after intra-arterial injection is similar to that observed earlier, in the liver, after intraportal injection. However, parallel isotope studies on the lodgement process (at 5 min and 3 h after injection) showed that the tumour cells trapped in the muscle microvasculature were destroyed at a higher rate than in the liver. Tumour cells kept in test tubes, and thus not being subjected to the shearing forces of the circulation, had a higher survival rate than cells trapped in the muscle. The results indicate that stronger retardation forces acting on the tumour cells in muscle (arterial dissemination) than in the liver (venous dissemination) may be one mechanism behind the increased tumour cell destruction in muscle. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Clinical and Experimental Metastasis
volume
6
issue
4
pages
285 - 289
publisher
Springer
external identifiers
  • pmid:3359711
  • scopus:0023918336
ISSN
1573-7276
DOI
10.1007/BF01753575
language
English
LU publication?
yes
id
a33bd6a2-241b-4dde-ad53-165c843455af (old id 1104073)
date added to LUP
2008-08-07 10:07:06
date last changed
2017-07-30 03:40:49
@article{a33bd6a2-241b-4dde-ad53-165c843455af,
  abstract     = {Differences in the lodgement of circulating tumour cells in various organs are considered an important factor in metastatic organ selection. The present vital microscopic studies show that the pattern of intravascular arrest of tumour cells in muscle after intra-arterial injection is similar to that observed earlier, in the liver, after intraportal injection. However, parallel isotope studies on the lodgement process (at 5 min and 3 h after injection) showed that the tumour cells trapped in the muscle microvasculature were destroyed at a higher rate than in the liver. Tumour cells kept in test tubes, and thus not being subjected to the shearing forces of the circulation, had a higher survival rate than cells trapped in the muscle. The results indicate that stronger retardation forces acting on the tumour cells in muscle (arterial dissemination) than in the liver (venous dissemination) may be one mechanism behind the increased tumour cell destruction in muscle.},
  author       = {Blomqvist, G and Skolnik, G and Braide, M and Bjursten, Lars Magnus and Blixt, A and Bagge, U},
  issn         = {1573-7276},
  language     = {eng},
  number       = {4},
  pages        = {285--289},
  publisher    = {Springer},
  series       = {Clinical and Experimental Metastasis},
  title        = {Differences in lodgement of tumour cells in muscle and liver},
  url          = {http://dx.doi.org/10.1007/BF01753575},
  volume       = {6},
  year         = {1988},
}