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Lymphocyte subpopulations and lymphokine production in children with constitutional aplastic anemia

Dohlsten, M; Hedlund, G; Békássy, Albert LU ; Lindén, Ola LU ; Garwicz, Stanislaw LU ; Wiebe, Thomas LU ; Sjögren, H O and Carlsson, R (1988) In Pediatric Hematology & Oncology 5(2). p.143-151
Abstract
The expression of lymphocyte surface markers as well as the production of interleukin-2 (IL-2) and interferon-gamma (IFN) by mitogen-stimulated peripheral blood mononuclear cells (MNC) have been studied in five children with constitutional aplastic anemia. A significantly reduced T4/T8 ratio was found and two of five patients also had a reduced percentage of B cells. One patient had a high percentage of HLA-DR positive T8+ cells, very suggestive of a high degree of circulating activated T suppressor/cytotoxic cells. IL-2 production was reduced in two patients, whereas IFN production was only reduced in one of these. The abnormalities found correlate with the duration of the bone marrow failure. The patients with the longest duration of... (More)
The expression of lymphocyte surface markers as well as the production of interleukin-2 (IL-2) and interferon-gamma (IFN) by mitogen-stimulated peripheral blood mononuclear cells (MNC) have been studied in five children with constitutional aplastic anemia. A significantly reduced T4/T8 ratio was found and two of five patients also had a reduced percentage of B cells. One patient had a high percentage of HLA-DR positive T8+ cells, very suggestive of a high degree of circulating activated T suppressor/cytotoxic cells. IL-2 production was reduced in two patients, whereas IFN production was only reduced in one of these. The abnormalities found correlate with the duration of the bone marrow failure. The patients with the longest duration of bone marrow failure also exhibited the lowest T4/T8 ratio. No spontaneous IFN production was detected in any of the patients. There was no clinical benefit or reversal of the immune abnormalities during and following treatment with cimetidine and cyclosporine A in two patients. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Pediatric Hematology & Oncology
volume
5
issue
2
pages
143 - 151
publisher
Hemisphere Pub. Corp.
external identifiers
  • pmid:2484652
  • scopus:0023885565
ISSN
1521-0669
DOI
10.3109/08880018809031264
language
English
LU publication?
yes
id
c00818be-8f78-4971-9802-918c8f78adff (old id 1104094)
date added to LUP
2008-08-07 10:19:31
date last changed
2017-01-01 04:26:50
@article{c00818be-8f78-4971-9802-918c8f78adff,
  abstract     = {The expression of lymphocyte surface markers as well as the production of interleukin-2 (IL-2) and interferon-gamma (IFN) by mitogen-stimulated peripheral blood mononuclear cells (MNC) have been studied in five children with constitutional aplastic anemia. A significantly reduced T4/T8 ratio was found and two of five patients also had a reduced percentage of B cells. One patient had a high percentage of HLA-DR positive T8+ cells, very suggestive of a high degree of circulating activated T suppressor/cytotoxic cells. IL-2 production was reduced in two patients, whereas IFN production was only reduced in one of these. The abnormalities found correlate with the duration of the bone marrow failure. The patients with the longest duration of bone marrow failure also exhibited the lowest T4/T8 ratio. No spontaneous IFN production was detected in any of the patients. There was no clinical benefit or reversal of the immune abnormalities during and following treatment with cimetidine and cyclosporine A in two patients.},
  author       = {Dohlsten, M and Hedlund, G and Békássy, Albert and Lindén, Ola and Garwicz, Stanislaw and Wiebe, Thomas and Sjögren, H O and Carlsson, R},
  issn         = {1521-0669},
  language     = {eng},
  number       = {2},
  pages        = {143--151},
  publisher    = {Hemisphere Pub. Corp.},
  series       = {Pediatric Hematology & Oncology},
  title        = {Lymphocyte subpopulations and lymphokine production in children with constitutional aplastic anemia},
  url          = {http://dx.doi.org/10.3109/08880018809031264},
  volume       = {5},
  year         = {1988},
}