Relations between blood flow and mucociliary activity in the rabbit maxillary sinus
(1988) In Acta Oto-Laryngologica 105(3-4). p.350-356- Abstract
- The effects of two sympathomimetic drugs on mucociliary activity and mucosal blood flow in the rabbit maxillary sinus were investigated by using a photo-electric technique (mucociliary activity) and laser Doppler flowmetry (blood flow). The responses produced were compared with effects of ligation of the external carotid artery. The alpha 1-agonist phenylpropanolamine (0.1-100 micrograms/kg) had no effect on the mucociliary activity, whereas the blood flow was reduced by 33.8 +/- 8.9% (mean +/- SE) when the dose was 100 micrograms/kg. The alpha 2-agonist xylometazoline (0.01-10.0 micrograms/kg) reduced mucociliary wave frequency by 21.6 +/- 4.6% (mean +/- SE) (maximum) for the dose 10 micrograms/kg. The blood flow was reduced by... (More)
- The effects of two sympathomimetic drugs on mucociliary activity and mucosal blood flow in the rabbit maxillary sinus were investigated by using a photo-electric technique (mucociliary activity) and laser Doppler flowmetry (blood flow). The responses produced were compared with effects of ligation of the external carotid artery. The alpha 1-agonist phenylpropanolamine (0.1-100 micrograms/kg) had no effect on the mucociliary activity, whereas the blood flow was reduced by 33.8 +/- 8.9% (mean +/- SE) when the dose was 100 micrograms/kg. The alpha 2-agonist xylometazoline (0.01-10.0 micrograms/kg) reduced mucociliary wave frequency by 21.6 +/- 4.6% (mean +/- SE) (maximum) for the dose 10 micrograms/kg. The blood flow was reduced by xylometazoline in the interval 1.0 to 10.0 micrograms/kg, with a maximum decrease of 65.8 +/- 2.6% (mean +/- SE) for the dose of 10 micrograms/kg. Ligature of the external carotid artery reduced blood flow by 76.0 +/- 4.6% (mean +/- SE), but did not significantly influence the mucociliary wave frequency. It is concluded that the decrease in mucociliary activity induced by alpha 2-adrenoceptor agonists is not due to a reduced blood flow. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1104135
- author
- Cervin, Anders LU ; Bende, Mats ; Lindberg, Sven LU ; Mercke, Ulf LU and Olsson, Peter
- organization
- publishing date
- 1988
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- laser Doppler flowmetry, mucociliary activity, blood flow, maxillary sinus, xylometazoline, phenylpropanolamine
- in
- Acta Oto-Laryngologica
- volume
- 105
- issue
- 3-4
- pages
- 350 - 356
- publisher
- Taylor & Francis
- external identifiers
-
- pmid:2898860
- scopus:0023938166
- ISSN
- 1651-2251
- DOI
- 10.3109/00016488809097018
- language
- English
- LU publication?
- yes
- id
- 9cb6cf35-f4a2-468e-bb5a-a059cedf7f24 (old id 1104135)
- date added to LUP
- 2016-04-01 16:08:39
- date last changed
- 2021-01-03 11:36:58
@article{9cb6cf35-f4a2-468e-bb5a-a059cedf7f24,
abstract = {{The effects of two sympathomimetic drugs on mucociliary activity and mucosal blood flow in the rabbit maxillary sinus were investigated by using a photo-electric technique (mucociliary activity) and laser Doppler flowmetry (blood flow). The responses produced were compared with effects of ligation of the external carotid artery. The alpha 1-agonist phenylpropanolamine (0.1-100 micrograms/kg) had no effect on the mucociliary activity, whereas the blood flow was reduced by 33.8 +/- 8.9% (mean +/- SE) when the dose was 100 micrograms/kg. The alpha 2-agonist xylometazoline (0.01-10.0 micrograms/kg) reduced mucociliary wave frequency by 21.6 +/- 4.6% (mean +/- SE) (maximum) for the dose 10 micrograms/kg. The blood flow was reduced by xylometazoline in the interval 1.0 to 10.0 micrograms/kg, with a maximum decrease of 65.8 +/- 2.6% (mean +/- SE) for the dose of 10 micrograms/kg. Ligature of the external carotid artery reduced blood flow by 76.0 +/- 4.6% (mean +/- SE), but did not significantly influence the mucociliary wave frequency. It is concluded that the decrease in mucociliary activity induced by alpha 2-adrenoceptor agonists is not due to a reduced blood flow.}},
author = {{Cervin, Anders and Bende, Mats and Lindberg, Sven and Mercke, Ulf and Olsson, Peter}},
issn = {{1651-2251}},
keywords = {{laser Doppler flowmetry; mucociliary activity; blood flow; maxillary sinus; xylometazoline; phenylpropanolamine}},
language = {{eng}},
number = {{3-4}},
pages = {{350--356}},
publisher = {{Taylor & Francis}},
series = {{Acta Oto-Laryngologica}},
title = {{Relations between blood flow and mucociliary activity in the rabbit maxillary sinus}},
url = {{http://dx.doi.org/10.3109/00016488809097018}},
doi = {{10.3109/00016488809097018}},
volume = {{105}},
year = {{1988}},
}