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Relations between blood flow and mucociliary activity in the rabbit maxillary sinus

Cervin, Anders LU ; Bende, Mats; Lindberg, Sven LU ; Mercke, Ulf LU and Olsson, Peter (1988) In Acta Oto-Laryngologica 105(3-4). p.350-356
Abstract
The effects of two sympathomimetic drugs on mucociliary activity and mucosal blood flow in the rabbit maxillary sinus were investigated by using a photo-electric technique (mucociliary activity) and laser Doppler flowmetry (blood flow). The responses produced were compared with effects of ligation of the external carotid artery. The alpha 1-agonist phenylpropanolamine (0.1-100 micrograms/kg) had no effect on the mucociliary activity, whereas the blood flow was reduced by 33.8 +/- 8.9% (mean +/- SE) when the dose was 100 micrograms/kg. The alpha 2-agonist xylometazoline (0.01-10.0 micrograms/kg) reduced mucociliary wave frequency by 21.6 +/- 4.6% (mean +/- SE) (maximum) for the dose 10 micrograms/kg. The blood flow was reduced by... (More)
The effects of two sympathomimetic drugs on mucociliary activity and mucosal blood flow in the rabbit maxillary sinus were investigated by using a photo-electric technique (mucociliary activity) and laser Doppler flowmetry (blood flow). The responses produced were compared with effects of ligation of the external carotid artery. The alpha 1-agonist phenylpropanolamine (0.1-100 micrograms/kg) had no effect on the mucociliary activity, whereas the blood flow was reduced by 33.8 +/- 8.9% (mean +/- SE) when the dose was 100 micrograms/kg. The alpha 2-agonist xylometazoline (0.01-10.0 micrograms/kg) reduced mucociliary wave frequency by 21.6 +/- 4.6% (mean +/- SE) (maximum) for the dose 10 micrograms/kg. The blood flow was reduced by xylometazoline in the interval 1.0 to 10.0 micrograms/kg, with a maximum decrease of 65.8 +/- 2.6% (mean +/- SE) for the dose of 10 micrograms/kg. Ligature of the external carotid artery reduced blood flow by 76.0 +/- 4.6% (mean +/- SE), but did not significantly influence the mucociliary wave frequency. It is concluded that the decrease in mucociliary activity induced by alpha 2-adrenoceptor agonists is not due to a reduced blood flow. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
laser Doppler flowmetry, mucociliary activity, blood flow, maxillary sinus, xylometazoline, phenylpropanolamine
in
Acta Oto-Laryngologica
volume
105
issue
3-4
pages
350 - 356
publisher
Taylor & Francis
external identifiers
  • pmid:2898860
  • scopus:0023938166
ISSN
1651-2251
DOI
10.3109/00016488809097018
language
English
LU publication?
yes
id
9cb6cf35-f4a2-468e-bb5a-a059cedf7f24 (old id 1104135)
date added to LUP
2008-08-07 11:07:09
date last changed
2017-01-01 06:56:56
@article{9cb6cf35-f4a2-468e-bb5a-a059cedf7f24,
  abstract     = {The effects of two sympathomimetic drugs on mucociliary activity and mucosal blood flow in the rabbit maxillary sinus were investigated by using a photo-electric technique (mucociliary activity) and laser Doppler flowmetry (blood flow). The responses produced were compared with effects of ligation of the external carotid artery. The alpha 1-agonist phenylpropanolamine (0.1-100 micrograms/kg) had no effect on the mucociliary activity, whereas the blood flow was reduced by 33.8 +/- 8.9% (mean +/- SE) when the dose was 100 micrograms/kg. The alpha 2-agonist xylometazoline (0.01-10.0 micrograms/kg) reduced mucociliary wave frequency by 21.6 +/- 4.6% (mean +/- SE) (maximum) for the dose 10 micrograms/kg. The blood flow was reduced by xylometazoline in the interval 1.0 to 10.0 micrograms/kg, with a maximum decrease of 65.8 +/- 2.6% (mean +/- SE) for the dose of 10 micrograms/kg. Ligature of the external carotid artery reduced blood flow by 76.0 +/- 4.6% (mean +/- SE), but did not significantly influence the mucociliary wave frequency. It is concluded that the decrease in mucociliary activity induced by alpha 2-adrenoceptor agonists is not due to a reduced blood flow.},
  author       = {Cervin, Anders and Bende, Mats and Lindberg, Sven and Mercke, Ulf and Olsson, Peter},
  issn         = {1651-2251},
  keyword      = {laser Doppler flowmetry,mucociliary activity,blood flow,maxillary sinus,xylometazoline,phenylpropanolamine},
  language     = {eng},
  number       = {3-4},
  pages        = {350--356},
  publisher    = {Taylor & Francis},
  series       = {Acta Oto-Laryngologica},
  title        = {Relations between blood flow and mucociliary activity in the rabbit maxillary sinus},
  url          = {http://dx.doi.org/10.3109/00016488809097018},
  volume       = {105},
  year         = {1988},
}