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Blunted pubertal growth after leukemia: a new pattern of growth hormone insufficiency

Moëll, Christian LU ; Garwicz, Stanislaw LU ; Westgren, Ulf LU ; Wiebe, Thomas LU and Albertsson-Wikland, K (1988) In Hormone Research 30(2-3). p.68-71
Abstract
Growth, age at menarche and spontaneous GH secretion were studied in girls after treatment for acute lymphoblastic leukemia (ALL). These girls had normal prepubertal growth but subnormal pubertal growth. Mean final height was 1 SD less than expected before puberty. The average age at menarche was significantly lower than the normal mean for Swedish girls. The mean 24-hour GH secretion was severely blunted and there was no increase during puberty. We suggest that girls treated for ALL, including CNS irradiation, have a relative GH insufficiency which becomes clinically obvious only when the girls cannot respond to the increased demands for GH in puberty.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Hormone Research
volume
30
issue
2-3
pages
68 - 71
publisher
Karger
external identifiers
  • pmid:3248779
  • scopus:0024240008
ISSN
0301-0163
language
English
LU publication?
yes
id
ddf1314d-ac32-432b-9b54-0567c86dd0d0 (old id 1104252)
date added to LUP
2008-08-07 13:21:00
date last changed
2017-01-01 07:13:05
@article{ddf1314d-ac32-432b-9b54-0567c86dd0d0,
  abstract     = {Growth, age at menarche and spontaneous GH secretion were studied in girls after treatment for acute lymphoblastic leukemia (ALL). These girls had normal prepubertal growth but subnormal pubertal growth. Mean final height was 1 SD less than expected before puberty. The average age at menarche was significantly lower than the normal mean for Swedish girls. The mean 24-hour GH secretion was severely blunted and there was no increase during puberty. We suggest that girls treated for ALL, including CNS irradiation, have a relative GH insufficiency which becomes clinically obvious only when the girls cannot respond to the increased demands for GH in puberty.},
  author       = {Moëll, Christian and Garwicz, Stanislaw and Westgren, Ulf and Wiebe, Thomas and Albertsson-Wikland, K},
  issn         = {0301-0163},
  language     = {eng},
  number       = {2-3},
  pages        = {68--71},
  publisher    = {Karger},
  series       = {Hormone Research},
  title        = {Blunted pubertal growth after leukemia: a new pattern of growth hormone insufficiency},
  volume       = {30},
  year         = {1988},
}