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The 5-hydroxytryptamine stimulated formation of inositol phosphate is inhibited in platelets from alcoholics

Simonsson, Per LU and Alling, Christer LU (1988) In Life Sciences 42(4). p.385-391
Abstract
The accumulation of inositol monophosphate (IP1) was measured after stimulation of 5-hydroxytryptamine2 (5-HT2) receptors on platelets from alcoholics and healthy controls. In controls, 5-HT induced a dose-dependent response with an EC50 = 2 x 10(-6) M and a maximal response at 10(-5) M. Ritanserin, a selective 5-HT2 antagonist, markedly reduced the accumulation. The IP1 formation after stimulation by 10(-5) M 5-HT was significantly impaired in platelets from alcoholics as compared to controls. This study indicates that the 5-HT2 receptor function is inhibited in alcoholics. It also illustrates the possibility of using IP1 formation in peripheral cells as a mean of studying receptor function in disease.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Life Sciences
volume
42
issue
4
pages
385 - 391
publisher
Elsevier
external identifiers
  • pmid:3123830
  • scopus:0023872391
ISSN
1879-0631
DOI
10.1016/0024-3205(88)90076-8
language
English
LU publication?
yes
id
8099d7ca-ec10-4b07-8e8f-05b9c5f3a26f (old id 1104304)
date added to LUP
2008-08-07 14:55:40
date last changed
2017-07-30 03:53:22
@article{8099d7ca-ec10-4b07-8e8f-05b9c5f3a26f,
  abstract     = {The accumulation of inositol monophosphate (IP1) was measured after stimulation of 5-hydroxytryptamine2 (5-HT2) receptors on platelets from alcoholics and healthy controls. In controls, 5-HT induced a dose-dependent response with an EC50 = 2 x 10(-6) M and a maximal response at 10(-5) M. Ritanserin, a selective 5-HT2 antagonist, markedly reduced the accumulation. The IP1 formation after stimulation by 10(-5) M 5-HT was significantly impaired in platelets from alcoholics as compared to controls. This study indicates that the 5-HT2 receptor function is inhibited in alcoholics. It also illustrates the possibility of using IP1 formation in peripheral cells as a mean of studying receptor function in disease.},
  author       = {Simonsson, Per and Alling, Christer},
  issn         = {1879-0631},
  language     = {eng},
  number       = {4},
  pages        = {385--391},
  publisher    = {Elsevier},
  series       = {Life Sciences},
  title        = {The 5-hydroxytryptamine stimulated formation of inositol phosphate is inhibited in platelets from alcoholics},
  url          = {http://dx.doi.org/10.1016/0024-3205(88)90076-8},
  volume       = {42},
  year         = {1988},
}