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Immunocytochemical localization of galanin in the rat male and female genital tracts and motor effects in vitro

Stjernquist, Martin LU ; Ekblad, Eva LU ; Owman, Christer LU and Sundler, F (1988) In Regulatory Peptides 20(4). p.335-343
Abstract
Galanin, a recently discovered neuropeptide, was studied in the rat male and female reproductive tracts by immunocytochemistry and in vitro pharmacology. Nerve fibers containing galanin immunoreactivity were most abundant in the female paracervical tissue, where they surrounded non-immunoreactive ganglion cells. Galanin nerves were also found in the uterus and Fallopian tubes, as well as in the vas deferens. When tested in vitro galanin contracted the smooth muscle of both the uterine horn and cervix. Galanin also slightly potentiated the response to electrical field stimulation in preparations from the uterine cervix and vas deferens, but it had no effect on the seminal vesicle. Galanin-(1-10), an N-terminal residue of galanin, also... (More)
Galanin, a recently discovered neuropeptide, was studied in the rat male and female reproductive tracts by immunocytochemistry and in vitro pharmacology. Nerve fibers containing galanin immunoreactivity were most abundant in the female paracervical tissue, where they surrounded non-immunoreactive ganglion cells. Galanin nerves were also found in the uterus and Fallopian tubes, as well as in the vas deferens. When tested in vitro galanin contracted the smooth muscle of both the uterine horn and cervix. Galanin also slightly potentiated the response to electrical field stimulation in preparations from the uterine cervix and vas deferens, but it had no effect on the seminal vesicle. Galanin-(1-10), an N-terminal residue of galanin, also contracted the uterine horn, though higher concentrations were required. The neurally induced contractions were not influenced by galanin-(1-10) in any of the smooth muscle preparations tested. The muscle receptors mediating the direct contractile effects in the uterine horn seem to require the N-terminus of galanin, while the neuromodulatory effects on the electrically induced contractile activity seem to need the C-terminal part or the whole galanin molecule. Galanin may thus function as a neuromediator in the rat male and female genital organs. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Galanin, Neuropeptide, Male and female genital tracts, Uterus, Vas deferens, Seminal vesicle, Smooth muscle, Immunocytochemistry, In vitro pharmacology
in
Regulatory Peptides
volume
20
issue
4
pages
335 - 343
publisher
Elsevier
external identifiers
  • pmid:2453074
  • scopus:0023831373
ISSN
1873-1686
DOI
10.1016/0167-0115(88)90068-7
language
English
LU publication?
yes
id
0ce85a28-d6de-4fba-afd8-2db5eff9b735 (old id 1104368)
date added to LUP
2008-08-08 09:29:26
date last changed
2017-07-30 03:48:43
@article{0ce85a28-d6de-4fba-afd8-2db5eff9b735,
  abstract     = {Galanin, a recently discovered neuropeptide, was studied in the rat male and female reproductive tracts by immunocytochemistry and in vitro pharmacology. Nerve fibers containing galanin immunoreactivity were most abundant in the female paracervical tissue, where they surrounded non-immunoreactive ganglion cells. Galanin nerves were also found in the uterus and Fallopian tubes, as well as in the vas deferens. When tested in vitro galanin contracted the smooth muscle of both the uterine horn and cervix. Galanin also slightly potentiated the response to electrical field stimulation in preparations from the uterine cervix and vas deferens, but it had no effect on the seminal vesicle. Galanin-(1-10), an N-terminal residue of galanin, also contracted the uterine horn, though higher concentrations were required. The neurally induced contractions were not influenced by galanin-(1-10) in any of the smooth muscle preparations tested. The muscle receptors mediating the direct contractile effects in the uterine horn seem to require the N-terminus of galanin, while the neuromodulatory effects on the electrically induced contractile activity seem to need the C-terminal part or the whole galanin molecule. Galanin may thus function as a neuromediator in the rat male and female genital organs.},
  author       = {Stjernquist, Martin and Ekblad, Eva and Owman, Christer and Sundler, F},
  issn         = {1873-1686},
  keyword      = {Galanin,Neuropeptide,Male and female genital tracts,Uterus,Vas deferens,Seminal vesicle,Smooth muscle,Immunocytochemistry,In vitro pharmacology},
  language     = {eng},
  number       = {4},
  pages        = {335--343},
  publisher    = {Elsevier},
  series       = {Regulatory Peptides},
  title        = {Immunocytochemical localization of galanin in the rat male and female genital tracts and motor effects in vitro},
  url          = {http://dx.doi.org/10.1016/0167-0115(88)90068-7},
  volume       = {20},
  year         = {1988},
}