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Titanium-hydrogen peroxide interaction: model studies of the influence of the inflammatory response on titanium implants

Tengvall, Pentti; Lundström, Ingemar; Sjöqvist, Lars; Elwing, Hans and Bjursten, Lars Magnus LU (1989) In Biomaterials 10(3). p.166-175
Abstract
In vitro studies of titanium and TiO2 as well as other metals were carried out to investigate the role of these metals in the inflammatory response through the Fenton reaction. The TiOOH matrix formed traps the superoxide radical, so that no or very small amounts of free hydroxyl radicals are produced. Ellipsometry and spin trapping with spectrophotometry and electron spin resonance (ESR) were used to study the interaction between Ti and H2O2. Spectrophotometry results indicated that Ti, Zr, Au and Al are low free OH-radical producers. We propose a new model for the titanium-tissue interface where the oxidized titanium surface is covered with a hydrated TiOOH matrix after the inflammatory reaction. This matrix is suggested to possess good... (More)
In vitro studies of titanium and TiO2 as well as other metals were carried out to investigate the role of these metals in the inflammatory response through the Fenton reaction. The TiOOH matrix formed traps the superoxide radical, so that no or very small amounts of free hydroxyl radicals are produced. Ellipsometry and spin trapping with spectrophotometry and electron spin resonance (ESR) were used to study the interaction between Ti and H2O2. Spectrophotometry results indicated that Ti, Zr, Au and Al are low free OH-radical producers. We propose a new model for the titanium-tissue interface where the oxidized titanium surface is covered with a hydrated TiOOH matrix after the inflammatory reaction. This matrix is suggested to possess good ion exchange properties, and extracellular components may interact with the Ti(IV)-H2O2 compound before matrix formation. The TiOOH matrix is formed when the H2O2 coordinated to the Ti(IV)-H2O2 complex is decomposed to water and oxygen. Superoxide (O2-) may be bound therein. The oxide layer initially present may be partly reformed to a TiOOH matrix due to the interaction with hydrogen peroxide. (Less)
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author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Titanium, hydrogen peroxide, oxygen radicals, inflammatory response
in
Biomaterials
volume
10
issue
3
pages
166 - 175
publisher
Elsevier
external identifiers
  • pmid:2541819
  • scopus:0024605097
ISSN
1878-5905
DOI
10.1016/0142-9612(89)90019-7
language
English
LU publication?
no
id
4f74ab18-9b64-450f-98cb-fbbc995f20a3 (old id 1104484)
date added to LUP
2008-08-06 09:10:25
date last changed
2017-11-19 03:39:39
@article{4f74ab18-9b64-450f-98cb-fbbc995f20a3,
  abstract     = {In vitro studies of titanium and TiO2 as well as other metals were carried out to investigate the role of these metals in the inflammatory response through the Fenton reaction. The TiOOH matrix formed traps the superoxide radical, so that no or very small amounts of free hydroxyl radicals are produced. Ellipsometry and spin trapping with spectrophotometry and electron spin resonance (ESR) were used to study the interaction between Ti and H2O2. Spectrophotometry results indicated that Ti, Zr, Au and Al are low free OH-radical producers. We propose a new model for the titanium-tissue interface where the oxidized titanium surface is covered with a hydrated TiOOH matrix after the inflammatory reaction. This matrix is suggested to possess good ion exchange properties, and extracellular components may interact with the Ti(IV)-H2O2 compound before matrix formation. The TiOOH matrix is formed when the H2O2 coordinated to the Ti(IV)-H2O2 complex is decomposed to water and oxygen. Superoxide (O2-) may be bound therein. The oxide layer initially present may be partly reformed to a TiOOH matrix due to the interaction with hydrogen peroxide.},
  author       = {Tengvall, Pentti and Lundström, Ingemar and Sjöqvist, Lars and Elwing, Hans and Bjursten, Lars Magnus},
  issn         = {1878-5905},
  keyword      = {Titanium,hydrogen peroxide,oxygen radicals,inflammatory response},
  language     = {eng},
  number       = {3},
  pages        = {166--175},
  publisher    = {Elsevier},
  series       = {Biomaterials},
  title        = {Titanium-hydrogen peroxide interaction: model studies of the influence of the inflammatory response on titanium implants},
  url          = {http://dx.doi.org/10.1016/0142-9612(89)90019-7},
  volume       = {10},
  year         = {1989},
}